Objective To study lymphocyte subsets changes in patients with malignant tumors during chemoimmunotherapy and the clinical significance. Metheds Fifty one cases were treated with chemotherapy and twenty six cases with chemoimmunotherapy. Lymphocyte subsets were determined by flow cytometry. Results Chemotherapy significantly decreased CD 3 +, CD 4 + and NK cells ( P 0 05). Chemoimmunotherapy elevated CD 8 + and NK cells ( P

OBJECTIVE: To investigate the clinical characteristics of intractable epistaxis and the application of nasal endoscopic surgery as the treatment. METHOD: The clinical data of 163 patients with intractable epistaxis were retrospectively analyzed. RESULT: The bleeding points were found in the following different sites, superior wall of inferior nasal meatus (31.3%, 51/163), olfactory cleft area (21.5%, 35/163), postero-inferior wall of nasal septum (20.8%, 34/163), middle nasal meatus (10.4%, 17/163) and Little area (8.6%, 14/163). The results showed that the bleeding points had correlation with age. According to the frequency of nasal bleeding, patients under the age of forty in turn occurred in superior wall of inferior nasal meatus, olfactory cleft area, Little area, postero-inferior wall of nasal septum and middle nasal meatus; patients over the age of forty occurred in superior wall of inferior nasal meatus, postero-inferior wall of nasal septum, olfactory cleft area, middle nasal meatus and Little area. There was a significant difference between the two groups (P < 0.05). All cases stopped bleeding after 1 time of treatment, and there was no complication during a followed-up for 3 months after management. Seven cases reoccurred bleeding in half a year, but they were finally cured under nasal endoscopic surgery. CONCLUSION The results indicate that we should pay attention to different bleeding points in different age groups. In addition, nasal endoscopic treatment is a reliable, convenient and effective method for intractable epistaxis and is the first choice after failed nasal packing.
Adult ; Aged ; Endoscopy ; Epistaxis ; surgery ; Female ; Humans ; Male ; Middle Aged ; Nasal Surgical Procedures ; Retrospective Studies

AIM: To investigate the effect of compound trabeculectomy in patients with primary acute angle closure glaucoma under persistent high intraocular pressure.

METHODS: From February 2015 to February 2016, we selected 62 cases(62 eyes)of primary acute angle closure glaucoma in our hospital, the control group 34 patients 34 eyes(preoperative intraocular pressure control in the normal range, intraocular pressure ≤ 21mmHg), the observation group 28 patients 28 eyes(preoperative intraocular pressure not in the normal range, the intraocular pressure 28-50mmHg and lasted for more than 3d). The two groups were treated with compound trabeculectomy and observed for visual acuity, intraocular pressure and so on.

RESULTS: Compared with preoperative, at 3mo postoperatively visual acuity improved, unchanged and decreased rate in observation group were 68%, 21% and 11%, the difference were not statistically significant compared with the control group(P>0.05). The postoperative intraocular pressure of the two groups compared with preoperative significantly decreased(P<0.05). The postoperative intraocular pressure of observation group and control group were 11.10±2.20mmHg and 11.73±2.71mmHg, the difference was not statistically significant(P>0.05). The preoperative and postoperative anterior chamber depth of observation group was lower than that in the control group(P<0.05). The postoperative anterior chamber depth of the two groups compared with preoperative increased(P<0.05). The postoperative axial length of the two groups compared with preoperative decreased(P<0.05). The postoperative complication rate of observation group was 14%, and the control group was 18%, the difference was not statistically significant(P>0.05).

CONCLUSION: Compound trabeculectomy in patients with primary acute angle closure glaucoma under high intraocular pressure is effective, but there still needs further study.

Objective To summarize the computed tomography (CT),magnetic resonance imaging (MRI) and fluorine-18 fluorodeoxy glucose (18 F-FDG) positron emission tomography (PET)/CT features of abdominal non-organi lymphangioma.Methods The retrospective cross-sectional study was conducted.The clinical data of 16 patients with abdominal non-organi lymphangioma who were admitted to the Affiliated Hospital of Ningbo University (11 patients) and the Changhai Hospital Affiliated to the Second Military Medical University (5 patients) between January 2009 and December 2015 were collected.All the patients received CT,MRI and 18F-FDG PET/CT examinations.Observation indicators:(1) imaging examinations;(2) imaging features of CT and MRI;(3) imaging features of PET/CT;(4) treatment and follow-up.Operations were applied to patients based on agreements of patients and families after finishing preoperative examinations,and postoperative pathological examinations were also performed.Follow-up using outpatient examination and telephone interview was performed once every 6-12 months postoperatively up to July 2016.Results (1) Imaging examinations:of 16 patients,12 underwent plan and contrast-enhanced CT scans,5 underwent plan and contrast-enhanced MRI scans,2 underwent plan MRI scans and 1 underwent 18 F-FDG PET/CT scan.One patient underwent simultaneously CT,MRI and 18 F-FDG PET/CT examinations and 2 patients underwent simultaneously CT and MRI examinations.(2) Imaging features of CT and MRI:① Classification of lymphangioma:unilocular cyst,plurilocular cyst and lymphangiomatosis were detected in 6,9 and 1 patients,respectively.② Lymphangioma location:9 of lymphangioma located in the single regions (6 with unilocular cyst and 3 with plurilocular cyst),7of lymphangioma involved multiple regions (6 with unilocular cyst and 1 with lymphangiomatosis).③ Lymphangioma diameter:lesion diameter was 4-25 cm,with an average of 12 cm,and diameter in 9 of lymphangioma was more than 10 cm.④ Lymphangioma shape:3 lymphangiomas were regular-shaped,showing round-like changes,and 13 lymphangiomas were irregular-shaped,showing'moulding'-like changes.⑤ Internal structure of lymphangioma:internal structures in 12 patients undergoing plain CT scans presented as liquid low density,with homogeneous density and-10-19 HU of CT value.MRI scans in 7 patients showed low signal on T1WI and high signal on T2WI,with homogeneous signals.No bleeding was found inside the abdominal non-organi lymphangiomas of 16 patients.The fluid-fluid level was detected in 1 patient with lymphangioma due to bleeding in pathological changes of liver.The septa and wall thickness was less than 2 mm in 15 patients with lymphangiomas,and was more than 3 mm in 1 plurilocular cyst lymphangioma,showing a equal density and isointensities on T1WI and T2WI.There was no nodule and calcification in 16 patients.⑥ Lymphangioma boundary:15 patients had clear boundary of lymphangioma and 1 had an unclear boundary of lymphangioma.⑦ Extrusion of adjacent organs:lymphangiomas in 10 patients were local concave,showing arc-shaped impression and hilar depression,lymphangiomas in 4 patients showed surrounding blood vessels,and fat density or signal inside lymphangioma was found in 2 patients.There were no surrounding intestine and lymph node enlargement in 16 patients.⑧ Lymphangioma reinforcement:of 14 patients with contrast-enhanced scans,septa and wall of lymphangiomas demostrated slight enhancement in 13 patients and moderate enhancement in 1 patient,and all contents showed no enhancement.(3) Imaging features of 18F-FDG PET/CT:inhomogeneous uptake of FDG was manifested in 1 plurilocular cyst lymphangioma,metabolic activity of the lesion was slightly higher than liver,SUVmax=3.71.(4) Treatment and follow-up:14 patients underwent single resection of lymphangioma (6 with unilocular cyst and 8 with plurilocular cyst);1 patient with plurilocular cyst lymphangioma underwent resection of lymphangioma,descending part of duodenum,pancreatic head and ascending colon;1 patient with lymphangioma underwent splenectomy due to smaller lesion.Sixteen patients were confirmed with lymphangioma by postoperative pathological examinations.Of 16 patients,13 were followed up for 6-31 months,with a median time of 15 months.During the follow-up,12 patients had no recurrence,with satisfactory outcomes,and 1 with recurrence of lymphangioma underwent multiple cervical and thoracic resections under right arm and sclerotherapy.Conclusion Abdominal non-organi lymphangioma has some imaging characteristics,it usually manifests as a larger mass with plurilocular cyst,moulding,liquid density/signal,thin septa and wall and clearly boundary.Plurilocular cyst lymphangioma has uptake of 18F-FDG.

OBJECTIVETo investigate the clinical significance of dynamic changes in the serum inflammatory cell factors consisting of β-endorphin (β-EP) , endothelins (ET) , tumor necrosis factor (TNF) , and nitric oxide (NO) after acute paraquat poisoning (APP).

METHODSThe 26 patients with APP (as observation group) were treated and the serum levels of plasma β-EP, ET, TNF, and NO were measured simultaneously. The 20 healthy volunteers from relatives of the patients (as control group) were also included in the study and their serum levels of β-EP, ET, TNF, and NO were measured.

RESULTSIn the 26 patients with APP, 10 were cured and 16 died. The serum levels of β-EP, ET, NO, and TNF in the 10 cured patients increased significantly immediately after admission, reached the peak values on day 2, and then decreased gradually and returned to the normal ranges after day 9. The serum levels of β-EP, ET, NO, and TNF in the 16 dead patients increased significantly on admission and kept rising in the course of treatment. The dead patients had significantly increased serum levels of β-EP, ET, NO, and TNF compared with the cured patients (all P<0.01).

CONCLUSIONCompared with those in cured patients with APP, the serum levels of β-EP, ET, NO, and TNF in dead patients with APP are significantly higher, keep rising, and maintain at high levels, indicating a severe condition.

Case-Control Studies ; Endothelins ; blood ; Humans ; Nitric Oxide ; blood ; Paraquat ; poisoning ; Tumor Necrosis Factor-alpha ; blood ; beta-Endorphin ; blood

Objective To confirm the epidemiological characteristics of coronavirus disease COVID-19 reported in Qianjiang city and provide a scientific basis for establishing and implementing effective infection prevention and control. Methods The cases of COVID-19 reported in Qianjiang were retrospectively collected and the epidemiological characteristics, including time, spatial and population distribution, clinical symptoms and exposure history, were analyzed using descriptive epidemiological method. Results A total of 198 confirmed cases of COVID-19, including 102 imported cases, were reported in Qianjiang city by March 31, 2020. Of the 198 patients, 9 died, and 189 were discharged. The male-to-female ratio was 1.2:1. Among the reported patients, most of the patients were aged 30-69. In the early stage, only imported cases were reported, subsequently, imported cases and local cases were prevalent together, and the peak of confirmed cases was appeared on February 15, 2020. Among the clinical types for admitted diagnosis, the common type (67.17%) was dominant, and fever (82.83%) and cough (67.17%) were the predominant clinical manifestations for primary diagnosis. The median time from illness onset to first visit was 3 days, the median time from first visit to confirmed diagnosis was 7 days, and the median interval from illness onset to diagnosis was 11 days. Conclusions With comprehensive measures taken, the pandemic of COVID-19 in Qianjiang have been brought under control. However, it is necessary to be alert to the potential risks brought by the resumption of work, production, education, as well as the outbound imported cases. Various prevention and control measures should continue to be strictly implemented.

OBJECTIVE：To investigate the role of clinical pharmacists in the therapy of gefitinib-caused liver injury complicated with cholecystitis in a patient with lung adenocarcinoma ，and to provide reference for the therapy of similar type of patients. METHODS ： Clinical pharmacists participated in the treatment for gefitinib-caused liver injury complicated with cholecystitis in a patient with lung adenocarcinoma. The patient took Gefitinib tablets orally for a long time for anti-tumor treatment，and was hospitalized due to abnormal increase of transaminase. The doctors gave intravenous infusion of tiopronin sodium+ acetylcysteine+reduced glutathione+citicoline to protect liver ，but the effect was not good. After consulting the literature and analyzing the patient ’s condition ， clinical pharmacists suggested that gefitinib should be stopped ， and Magnesium isoglycyrrhizinate injection 0.2 g+5％ Glucose injection 250 mL，ivgtt，qd for liver protection treatment. After discharge ，the patient took Gefitinib tablets orally and was admitted to hospital again due to abnormal increase of transaminase ，and suffered from non-infectious and non-calculous cholecystitis. Clinical pharmacists suggested continuing intravenous drip of Magnesium isoglycyrrhizinate injection 0.2 g+5％ Glucose injection 250 mL，qd for liver protection treatment ，oral administration of Danshu capsules 0.9 g，tid for conservative treatment ；at the same time ，closely monitoring the changes of related indicators. After discharge，clinical pharmacists instructed patients to stop gefitinib ，and take Icotinib hydrochloride tablets 0.125 g，tid+Compound Taxus capsules 0.6 g，tid for anti-tumor treatment. RESULTS ：The doctors adopted the opinions of clinical pharmacists ，and the transaminase levels returned to normal ，and the symptoms of cholecystitis basically subsided. CON CLUSIONS：In the treatment of gefitinib-caused liver injury complicated with cholecystitis in patients with lung adenocarcinoma ， clinical pharmacists 135） assisted doctors to improve the treatment plan and ensure the effectiveness of drug use.

OBJECTIVE：To observe therapeutic efficacy and safe ty of Huhuang burn liniment on the prevention and treatment of radiation dermatitis patients with nasopharyngeal carcinoma （NPC）. METHODS ：Totally 129 NPC patients were collected from our hospital during Aug. 2018-Feb. 2020. They were numbered according to the order of radiotherapy ，the ones with odd number were included into observation group （65 cases）and the ones with even number into control group （64 cases）. Both groups received routine radiotherapy and skin nursing. Control group were evenly smeared with Shirun shaoshang cream in the radiation field during radiotherapy ，and observation group were smeared with Huhuang burn liniment. The smearing area should be 1 cm beyond the edge of radiation field ，3 times a day until the end of stage 1 radiotherapy（33-38 times in total ）. The skin lesions of the two groups were observed ；the appearance time and healing time of skin lesion ，RTOG score and NRS score were recorded. The levels of serum cytokines （TNF-α，IL-6，IL-8 and IL- 10）were detected in 2 groups at 0，15th and 30th time of radiotherapy. The occurrence of ADR was recorded in 2 groups during treatment. RESULTS ：The appearance time of skin lesion in observation group was significantly longer than control group ；the healing time of skin lesion in observation group was significantly shorter than control group （P＜0.01）. RTOG grading of radiodermatitis in the two groups was mainly grade 1，but no grade 3 or 4 was found. There was no significant difference in the proportion of patients with differen RTOG grades （P＞0.05）. The highest NRS score of control group and observation group were 3 and 2 points respectively ，and the proportions of patients with 0-3 points in the two groups were statistically significant （P＜0.05）. There was no significant difference in serum cytokine levels between @qq.com 2 groups at 0 time of radiotherapy （P＞0.05）. The serum cytokine levels of 2 groups were increased significantly at 15th @qq.com time of radiotherapy ， but t he observation group was significantly lower than control group at the same period （P＜0.05 or P＜0.01）. At 30th time of radiotherapy ，the cytokine levels of 2 groups decreased significantly ，compared with 15th time of radiotherapy ，the observation group was significantly lower than the control group at the same period （P＜0.05 or P＜0.01）；the levels of TNF-α，IL-6 and IL- 10 in control group as well as the level of IL- 6 in observation group were significantly higher than the same group at 0 time of radiotherapy （P＜0.05 or P＜0.01）. There was no ADR such as allergy ，rash，smear site infection in the two groups during the treatment. CONCLUSIONS ：Huhuang burn liniment has a good effect of preventing and treating radiation dermatitis of NPC patients ，delays the occurrence of skin lesion，shortens the healing time of skin lesion ，relieves pain and reduces the level of serum cytokines with good safety.

Objective To explore the influencing factors of bone mineral density (BMD) in obese children in Qianjiang area and analyze the correlation between BMD and insulin resistance. Methods The data on pediatric cases from the outpatient department of Jianghan Oilfield General Hospital in Qianjiang from January 2018 to December 2022 were collected. A total of 183 obese children who met the inclusion and exclusion criteria were included in the study and selected in the observation group. A total of 352 children undergoing physical examination during the same period were selected as the control group. Results The body mass, waist circumference, waist to hip ratio, and BMI of obese children were significantly higher than those of the control group (P<0.001). Biochemical indexes including FBG, FINS, Home-IR, ALP, and LDL-C in obese children were significantly higher than those in the control group (P<0.05), while bone mineral density, Ca, P, sOC and HDL-C were significantly lower than those in the control group (P<0.001). The bone mineral density of obese children was significantly correlated with their exercise intensity, sunshine exposure duration, sitting time, intake of milk and dairy products, intake of sweets, supplementation of trace elements, BMI, Home-IR, and sex (all P<0.05). BMI, Home-IR, sex, exercise intensity, and sunshine exposure length were independent risk factors affecting bone mineral density of obese children (all P<0.05). Bone mineral density was negatively correlated with BMI and Home-IR (P=0.028 and0.017, respectively), and positive correlation with exercise intensity and sunlight exposure (P=0.033). Conclusion BMD of obese children in Qianjiang area is affected by gender, body mass index, diet, vitamin intake, and physical activity, and is negatively correlated with insulin resistance. Home-IR can be used as a reference for screening BMD of obese children.

【Objective】 To explore the effects of platelet-rich plasma (PRP) injection combined with pregabalin on pain and knee function in knee osteoarthritis (KOA). 【Methods】 A total of 220 patients with KOA in our hospital, between June 2020 and April 2022, were enrolled and randomly divided into observation group (n=110) and the control (n=110). The observation group was given PRP injection combined with pregabalin, while control group was given sodium hyaluronate combined with pregabalin. The clinical curative effect, osteoarthritis index (WOMAC), pain level (VAS), knee function [Lysholm-Ⅱ scale, Rasmussen scale], levels of repair-promoting factors [transforming growth factor-β1 (TGF-β1), bone morphogenetic protein 4 (BMP4), insulin growth factor 1 (IGF-1)], inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor α (TNF-α)], oxidative stress indexes [superoxide dismutase (SOD), nitric oxide (NO)] and blood routine [white blood cell count (WBC), platelet count (Plt)], and the occurrence of adverse reactions in the two groups were compared. 【Results】 The response rate of treatment was higher in observation group than control group [94.55% (104/110) vs 83.64% (92/110), P<0.05]. After treatment, scores of WOMAC and VAS were lower in observation group than the control group [points: 43.39±5.92 vs 49.40±6.18, 2.50±0.33 vs 2.87±0.39, P<0.05], and scores of Rasmussen and Lysholm-Ⅱ were higher in observation group [points 60.66±6.15 vs 55.13±5.49, 77.04±6.18 vs 72.15±7.25, P<0.05]. After treatment, levels of serum TGF-β1, BMP4 and IGF-1 were higher in observation group than control group [(944.80±54.92) ng/L vs (901.45±46.82) ng/L, (126.79±9.81) pg/mL vs (118.44±8.45) pg/mL, (96.86±5.15) μg/L vs (91.47±5.06) μg/L, P<0.05]. After treatment, levels of serum IL-6, TNF-α and NO were lower in observation group than control group [(124.92±20.58) pg/mL vs (149.10±22.91) pg/mL, (1.90±0.31) μg/L vs (2.64±0.52) μg/L, (81.05±6.83) μmol/L vs (86.22±5.84) μmol/L], while SOD was higher in observation group [(109.29±10.18) NU/mL vs (102.77±9.98) NU/mL, P<0.05)]. The levels of peripheral blood WBC and PLT in the two groups were similar after treatment (P>0.05). There was no significant difference in incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 PRP injection combined with pregabalin can effectively improve knee function, relieve pain, reduce levels of inflammatory factors and oxidative stress injury, and promote the expressions of repair-promoting factors in KOA patients.