1.Applications of IVUS in Modern PCI Procedure
Qian ZHANG ; Tong ZOU ; Xue YU
Journal of Kunming Medical University 2013;(8):160-165
Intravascular ultrasound (IVUS) is a commonly used technology in percutaneous coronary intervention (PCI) procedure. It has higher resolution and repeatability, and more importantly, it can make the vascular structure visiable which shows the plaque morphology and component, compared with traditional coronary angiography. Most researches indicated that IVUS can help doctors find out the optimized stent size, stent malapposition,stent disexpansion,and procedure complication, thus reduce the incidence of restenosis and stent thrombosis. IVUS has been widely applied in research about the predictors of PCI complication, these results benefit us to make better decision on PCI procedure. In this article, we reviewed the studies based on IVUS technology during the last 10 years and summrized according to restenosiss and stent thrombosis with BMS (bare metal stent) and DES (drug eluting stent) .
2.Chinese Characters Processing of Healthy Subjects: A Functional Magnetic Resonnce Imaging Study
Qian PEI ; Luping SONG ; Tong ZHANG
Chinese Journal of Rehabilitation Theory and Practice 2014;20(11):1004-1007
Objective To investigate the Chinese characters processing in healthy subjects with functional magnetic resonance imaging (fMRI). Methods 10 healthy subjects were asked to finish the dual-task paradigm Keying/Reading and single-task paradign Keying or Reading.The active area and partial lateralization index in brains of them were investigated with fMRI with block design. Results and onclusion The tasks activated the right inferior frontal gyrus, bilateral parietal and cerebellar cortex. The laterality index showed that the left brains were more active in the tasks.
3.Effects of Attention Training on Interference Effect of Dual-task Paradigm in Poststroke Nonfluent Aphasiacs: A Functional Magnetic Resonnce Imaging Study
Qian PEI ; Luping SONG ; Tong ZHANG
Chinese Journal of Rehabilitation Theory and Practice 2015;21(2):125-129
Objective To investigate the effect of attention training on cortical activation area and lateralization index in interference effect of dual-task paradigm as the poststroke nonfluent aphasiacs processing the Chinese character tasks. Methods 20 cases with nonfluent aphasia after stroke were divided into the training group and the control group, who accepted attention training and cognitive training respectively, 30 min a time, 5 times a week, for 4 weeks. They were investigated the cortical activation area and lateralization index caused by interference effect of dual-task paradigm under block design. Results The right inferior frontal gyrus, bilateral parietal and cerebellar cortex were activated before training in both groups, and more activated after attention training, but no change after cognitive training. Lateralization index suggested that the right brain was more activated before training, while the left side was activated after attention training, but no change after cognitive training. Conclusion The right inferior frontal gyrus, bilateral parietal and cerebellar cortex are very important in solving the dual task interference in the attention stage, and they are activated after attention training. It indicates that attention training makes a significant functional reorganization on Chinese character processing in poststroke nonfluent aphasiacs.
4.Influence of Attention Training on Chinese Character Processing Capability in Poststroke Nonfluent Aphasiacs
Qian PEI ; Tong ZHANG ; Luping SONG
Chinese Journal of Rehabilitation Theory and Practice 2015;21(3):296-302
Objective To explore the influence of attention training on Chinese character processing capability in poststroke nonfluent aphasiacs. Methods 60 stroke patients with nonfluent aphasia and cognition dysfunction were divided into control group (n=30) and experimental group (n=30). The trainings (attention training and cognition training) were respectively 30 minutes each time, 5 times each week for 4 weeks. The change of reaction time and error rate were compared before and after they were performing the orthographic, semantic and phonological tasks. Results In the dual-task paradigm the change of reaction time and error rate in orthographic and semantic tasks of the experimental group were all higher than the control group (P<0.001). But there was no difference between the two groups in the phonological task (P>0.05). In the single task paradigm there was no difference between the two groups (P>0.05). Conclusion 1. Attention training can improve the processing capacity significantly in orthographic and semantic tasks in the dual-task paradigm because the volume and distributive ability of attention improve significantly. 2. Attention training can't improve the processing capacity in phonological tasks in the dual- task paradigm because reading aloud and judging are required to process the vowel simultaneously. So that the competion intensifies and it is more difficult to finish the task. 3. In the single task paradigm, there is no significant difference between the influence of the two trainings in poststroke nonfluent aphasiac because the single task needs little attention and the change in the control group is enough.
5.Systematic review of acupuncture therapy for acute ischemic stroke
Tong ZHANG ; Li ZHANG ; Huimin ZHANG ; Qian LI
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(01):-
0.05).3 researches used Scandinavian Stroke Scale(SSS),compared the difference of before and after treatment of treatment group and control group,the result showed acupuncture or electro-acupuncture can improve the neurological function,there was statistic meaning(P
6.A case report of Kearns-Sayre syndrome.
Wei-hua ZHANG ; Qian TONG ; Dong-mei CHEN
Chinese Journal of Cardiology 2011;39(4):369-369
7.The Transformations of State in Aged patients Suffer from Hepatocirrhosis Incorporated with Diabetse were Observat through the Iamirudine Therapy
Jianya XUE ; Yongmei ZHU ; Qian ZHANG ; Qunyan TONG
Journal of Medical Research 2006;0(11):-
Objective The transformations of clinical state in aged patients suffered from hepatocirrhosis incorporated with diabetes were observed through the lamivudine therapy.Methods The clinieal state,state of diabetes related to the grade of liver function and the influence of clinical state by lamivncline treatment in 36 patients were analyzed.Results Those with representative symptom of diabetes were less observed(2.8%) in these 36 patients.The patients complicating with the spontaneous bacterial peritonitis had a high chance.The blood glucose level show obviously abnormas after the liver function got worse.With the liver function improved through combined therapy include lamivudine,the blood glucose level turned to a low level.Conclusion The clinical state in aged patients suffered from hepatocirrhosis with Ⅱ type diabetes is untypical.The blood glucose level appearances direct correlation with the condition of hepatocirrhosis.Treatments with lamivudine was favorable for control of blood glucose level and better liver function.
8.Effects of mimic ischemic preconditioning on hyperpolarizaion-activated current of cultured sinoatrial node cells of neonatal rat
Qian ZHANG ; Shifei TONG ; Ji HUANG ; Zhiyuan SONG
Journal of Third Military Medical University 1983;0(04):-
Objective To compare the effects of stimulated ischemic preconditioning (IP) and ischemia/reperfusion (I/R) on the hyperpolarization-activated current (I_ f ) of sinoatrial node cells and explore the mechanisms of electrophysiological protection of IP. Methods The sinoatrial node cells cultured for 2 d were randomized to three groups: ① Control in which the cells were cultured at 37 ℃ in the mimic reperfusion solution, meanwhile the mixture of 95% O_ 2 and 5% N_ 2 was ventilated; ② I/R in which the cells were cultured in the mimic ischemic solution and simultaneously the mixture of 95% O_ 2 and 5% N_ 2 was ventilated for 3 h, then cultured in the mimic reperfusion solution and simultaneously the mixture of 95% O_ 2 and 5% N_ 2 was ventilated for 4 h; ③ IP in which the cells underwent ischemia for 10 min and reperfusion for 10 min, repeated once. Then the cells were treated as the same as the I/R group. After 4-hour reperfusion, I_ f was recorded by whole-cell patch clamp technology. Results I/R significantly enhanced the current density of I_ f , shifted the current activation curve to more positive value by changing the half-activation voltage from (-98.9?2.4) mV to (-85.2?2.5) mV (P
9.Protective effect of mimic ischemic preconditioning on viability of cultured sinoatrial node cells of neonatal rats
Qian ZHANG ; Zhiyuan SONG ; Shifei TONG ; Li ZONG
Journal of Third Military Medical University 1984;0(01):-
Objective To compare the effects of different ischemic preconditioning (IP) protocols on the viability of primary cultured sinoatrial node cells from neonatal rats for investigating the protective effect of IP. Methods The cells were randomized into eleven groups: control, ischemia/reperfusion (I/R), IP1 (preconditioned with ischemia/reperfusion for 5 min), IP2 (preconditioned with 2 cycles of ischemia/ reperfusion for 5 min), IP3 (preconditioned with 3 cycles of ischemia/reperfusion for 5 min), IP4 (preconditioned with ischemia/reperfusion for 10 min), IP5 (preconditioned with 2 cycles of ischemia/reperfusion for 10 min), IP6 (preconditioned with 3 cycles of ischemia/reperfusion for 10 min), IP7 (preconditioned with ischemia/reperfusion for 20 min), IP8 (preconditioned with 2 cycles of ischemia/reperfusion for 20 min), and IP9 (preconditioned with 3 cycles of ischemia/reperfusion for 20 min). PI positive staining rate and changes of D 490 after 3 h ischemia/4 h reperfusion were determined by PI staining and MTT chromatometry. Results ① D 490 value in sinoatrial node cells in each experimental group was significantly lower than that in the control group, but that in IP2, IP3, IP4, IP5, and IP7 groups was significantly higher than that in I/R group (P
10.Effects of mimic ischemic preconditioning on [Ca~(2+)]_i and L-type calcium current of cultured sinoatrial node cells of neonatal rat
Qian ZHANG ; Zhiyuan SONG ; Shifei TONG ; Ji HUANG
Journal of Third Military Medical University 1988;0(06):-
Objective To study the effects of mimic ischemic preconditioning (IP) on i and I-LCa of sinoatrial node cells and explore the protective effects of IP. Methods Cells were randomized to three groups: control, ischemia/reperfusion (I/R), IP. After labeled with fura4, fluorescence intensity of i was studied with laser confocal microscopy and I-LCa was recorded by whole-cell patch clamp technology. Results IP significantly reduced the fluorescence intensity of i and enhanced the peak of I-LCa as compared with I/R, shifted the I-V curve to more negative value. Conclusion IP can reduce the overload of i caused by I/R and increase I-LCa weakened by I/R.