With the doses of Spirulina compound tablet (FST) 1.5g?kg 1 ,3g?kg 1 by ig administration to normal rats,alloxan (ALX) induced diabetic rats and hyperlipidemic model rats respectively for 14 days ,then the fast blood glucose(FBG) and the serum lipids were detected.The results showed that FST could decrease the FBG and the serum TC,TG,LDL C,increase HDL C in normal and in diabetic rats.(But FST 1.5g?kg 1 had no significant effect on TG,HDL C in normal rats).In addition,it was found that FST could remarkably decrease the level of serum TC,TG, and LDL C,as well as increase HDL C in hyperlipidemic model rats.It is suggested that FST not only significantly decrease the FBG and the lipids contents both in normal and in diabetic rats,but also remarkably decrease the serum lipids level in hyperlipidemic model rats. [WT5HZ]

Background Hypertension and dyslipidemia are the 2 important risk factors of cardiovascular affecting the prognosis of cardiovascular disease. However paucity data of characteristics of lipid metabolism and prognosis of cardiovascular diseases in high-risk groups with hypertension are available. Objective To analyze the lipid metabolism level and the relevant risk factors of inpatients with essential hypertension (EH) from 2000 to 2007. Methods Retrospective study was performed based on the clinical characteristic and the relationship between different kinds of hyperlipidemia and target organ damages in inpatient with EH. Results For the level of triglyceride (TG) and the prevalence of hypertriglyceridemia,males(n=3056) were significantly higher than females(n=1932)(P

Based on the word-formation of Medical English terms,this paper gives a comprehensive analysis of their transformation and adaptation in Chinese language and culture.Three major factors are discussed for the application and diversification of medical English terms,including the language family in translation,linguistic context,situational context and cultural context.

Objective To investigate the awareness of HIV/AIDS and risk behaviors among migrant workers at construction sites in Beijing. Methods The methods of cluster sampling was employed,a questionnaire survey was administered among 1000 migrant workers from two construction sites and a face-to-face interview with the informed consent was conducted in a limited scope.Results There was considerable disparity in the awareness of the routes of AIDS transmission;66.8% of the migrant workers were aware that the condom could reduce the risk of infection,but 51% of them had never used it.Only 2.3% of the migrant workers had sexual intercourse with female sex workers.Conclusion Although the migrant workers under survey have some basic knowledge on HIV/AIDS,their essential understanding was mostly vague,and financial condition have restricted to a great extent their risk behaviors.

To study the effect of Spirulina Com pound Tablet(FST) on the level of serum lipids in hyperlipidemic mice.METH ODS:The experimental hyperlipidemic mice were divided into four groups.Amo ng them,two groups were treated with FST 1.5g/kg,3g/kg respectively by ig admini stration,and one group was given lipanthyl 0.05g/kg by ig administration as the positive drug control,another group was received physiological saline by ig admi nistration as the hyperlipidemic control.The treatment were consecutively carrie d out for 14 days.Then the serum lipids of each group were determined with autom atic biochemistry analysor.RESULTS:Compared with the hyperlipidemic control group,it was found that FST could significantly decrease the level of to tal serum cholesterol(TC),triglyceride(TG),and low density lipoprotein-choleste rol(LDL-C),as well as remarkably increase the content of serum high density lip oprotein-cholesterol(HDL-C) and the value of HDL-C/TC in the hyperlipidemic m ice.Furthermore,the results also showed that FST could obviously raise the conce ntration of the serum apolipoproteinAI(apoAI) and reduce the concentration of ap olipoproteinB(apoB)(Whereas FST 1.5g/kg had no significant effect on apoB).CONCLUSION:FST could remarkably decrease the content of serum lipids and regulate the apolipoprotein in the hyperlipidemic mice.

AIM:To study the effect of contact system in monocyte adhesion induced by urokinase-type plasminogen activator (U-PA). METHODS:U937 cells were labeled with [3H] thymidine in the culture medium, test reagents were added into the cell suspension in 24-well plates. The counts?min -1 were counted in a liquid scintillation counter. RESULTS:U-PA-induced monocyte adhesion was inhibited by high-molecular-weight kininogen and kallikrein, and promoted by factor Ⅻ and plasminogen. CONCLUSION:these contact system proteins may be important modulators of U-PA-induced monocyte adhesion, a process which is involved in many pathophysiological events.

Objective To research the expression and clinical significance of SALL 4 gene in cervical cancer .Methods The ex-pression of SALL4 in 56 samples of cervical cancer and 35 samples of normal cervical tissues was detected by immunohistochemistry and RT-PCR ,and its relationship with the clinicopathological characteristics of cervical cancer was analyzed .Results The expres-sion of SALL4 mRNA was 2 .56 ± 0 .22 in cervical cancer tissues ,which was significantly higher than 0 .38 ± 0 .03 in the normal cer-vical tissues .the difference between them had statistical significance(t=58 .1 ,P<0 .01);the positive expression rate of SALL4 pro-tein was 80 .4% (45/56) in cervical cancer ,which was significantly higher than 11 .4% (4/35) in the normal cervical tissues (χ2 =41 .177 ,P<0 .01) .The positive expression of SALL4 in the cervical cancer tissues was correlated with the differentiation status of tumor ,which in the middle and high differentiation groups was lower than that in the low differentiation group (χ2 =4 .226 ,P=0 .039) ,but had no correlation with age ,International Federation of Gynecology and Obstetrics (FIGO) stage ,tumor size ,pathologi-cal type and lymph node metastasis(P>0 .05) .Conclusion SALL4 is highly expressed in the cervical cancer tissues and correlated with the tumor differentiation ,which might play an important role in the occurrence and development of cervical cancer .

Objective To further recognize the coronary artery three vessel disease by studying the abnormal change of the electrocardiogram(ECG)and echocardiography of ischemic heart disease patients and unstable angina pectoris patients,and to analyze the results of coronary angiography.Methods Coronary arteriography for 2 654 patients diagnosed as ischemic heart disease,unstable angina pectoris,were conducted and the result of coronary arteriography were compared with the ECG and echocardiography.Results There were certain statistically significant correlation among the ECG,echocardiography abnormal change and three vessel coronary artery disease(ECG:χ2 =9.02,P <0.01;echocardiography:χ2 =14.36,P <0.01).The sensitivity,specificity,false positive rate,and false negative rate of ECG were 71.46%,27.47%,62.26% and 28.50% respectively.The sensitivity,specificity,false positive rate, and false negative rate of echocardiography were 61.27%,27.08%,72.91% and 38.72% respectively.ECG′s change of patients appear in 8 or more leads when angina pectoris attacks exist,the incidence of chest lead terminal positive T wave were higher than 90.00%.Ⅲ lead fQRS wave group or low voltage changeed and AVR lead ST seg-ment elevation were accounting for 82.61% and 56.52% respectively.Conclusion There are certain correlation and predictive value among the ECG,echocardiography and three vessel coronary artery disease.There are characteristic waveform change of ECG when angina pectoris attacks exist.

Physical exercise is a low-cost, easy-to-implement therapeutic intervention. In recent years, it has been found that exercise has a protective effect on retinal diseases such as diabetic retinopathy, age-related macular degeneration and retinitis pigmentosa. The mechanism may be related to enhancing retinal defence against oxidative stress, reducing glutamate secretion and inhibiting retinal cell apoptosis through BDNF/TrkB pathway. This paper reviews the recent literature related to the protective effect of exercise on retina from animal experiments, clinical studies and mechanism investigation.

Objective: To investigate the relationship between serum HGF levels and clinical severity of essential hypertension (EH). Methods: The serum HGF concentrations of 44 patients with EH were measur ed by ELISA. Results: The serum HGF levels in patients with EH w ere higher than that in control. Furthermore, the serum HGF levels of EH patient s with coronary atherosclerosis (CAS) were significantly higher than those of EH patients without CAS ［(920.8±250.0） pg/ml vs （747.9±132.1） pg/ml, P <0.01］ or control ［（643.8±98.2） pg/ml, P<0.01)］.The changes of HGF l evel were correlated with the clinical courses (r=0.63, P<0.01) and stag es (r=0.69, P<0.01) of hypertension. Conclusion: HGF may be considered as a new index for the severity of hypertension and an useful bio chemical parameter for estimating the development of atherosclerosis.