Objective To evaluate effects of three modalities with intravenous immrnoglobulin(IVIG) infusion in the treatment of Kawasaki disease(KD). Methods 76 KD cases were treated by the IVIG in the Deparment of Pediatric of Kaiping Central Hospital from 1998 to 2004.The three modalities were as follows: four days treatment(0.4 g/kg,for four days continuance),two days treatment(1 g/kg,for two days continuance),one day treatment(2 g/kg,for one day).Results(1) In treatment of fever,conjunctiva congest and mouth change,and recover in white blood cell and erythrocyte sedimentation,one day treatment and two days treatment had better curative effects with significantly difference(P0.05).(3)In the prevention of coronary artery dilate(CAD),one day treatment and two days treatment had better curative effects significantly difference(P