Acute kidney injury( AKI) is a variety of causes leading to rapid impaired renal function, causing glomerular filtration rate reduced,blood urea nitrogen elevated,serum creatinine increased,urine out-put decreased,resulting in the disorder of the human body environment,so the body can not maintain homeo-stasis. AKI increases the risk of mortality and chronic kidney disease in neonate. To understand the progress of AKI on diagnostic criteria,pathogenesis,early biomarker,treatment and prognosis,it is extremely important to guide clinical diagnosis and treatment,improve the outcome and reduce the mortality of AKI in neonate.

Objective To investigate the changes of serum estradiol (E2) and tumor necrosis factor (TNF)-αin endome-triosis (EMS) patients with pelvic pain, and their correlation thereof. Methods The serum levels of E2 and TNF-α were mea-sured with ELISA in 113 EMS patients with pelvic pain ( 37 cases in mild pain group, 41 cases in moderate pain group and 35 cases in severe pain group) and 30 healthy women without EMS (control group). Results There were no significant differences in the serum levels of E2 and TNF-α between mild pain group and normal control group. There were significantly higher levels of E2 and TNF-αin moderate and severe pain groups than those of mild pain group and normal control group. The serum levels of E2 and TNF-αwere significantly higher in severe pain group compared with those of moderate pain group (P<0.05). There was no correlation between serum levels of E2 and TNF-αin mild pain group. The serum levels of E2 and TNF-αwere positive-ly correlated between moderate pain group and severe pain group (P<0.05). Conclusion The increased E2 level can play a role in chronic pelvic pain of EMS by inducing macrophage to release TNF-α.

[Objective] To establish a method for the determination of geniposide in Jinzhi Jieyin Gargle by RP- HPLC. [ Methods ] SupelcosilTM LC - 18 (150 mm ?4.6 mm, 5?m) was used as the analytical column, methanol - water -phosphoric acid (25∶75∶0.12 ) as mobile phase and the detection wave - length at 240 run. [Results] Within the range of 0.175-1.84?g, geniposide showed a good linearity ( r = 0.9999 ). The average recovery was 99.93%(n=5, RSD = 1.16%). [Conclusion] This method can be used for the quality control of Jinzhi Jieyin Gargle.

Cerebrovascular disease is currently one of the major diseases that result in the deaths of human.Its incidence elevates year by year,and there is a trend of younger.Stroke in young adult accounts for 25％ ～ 33％ in all stroke patients.Once a young man has a stroke,his quality of life will drop dramatically,and it will also bring a heavy burden to the family and society.Therefore,the etiologies of stroke in young adults should be summarized in order to achieve early diagnosis and early treatment.It is very important for improving of their prognoses.Cryptogenic stroke accounts for about 30％ in all strokes.The possible etiologies of cryptogenic stroke in young adults include heart diseases,arthritis,artery dissection,obstructive sleep apnea syndrome,and drug abuse,etc.

Objective To explore the advantages and disadvantages of the double lumen endotracheal intubation and single -lumen endo-tracheal intubation and continuous carbon dioxide insufflation in thoracoscopic esophagectomy .Methods The clinical data of 90 patients in our department of thoracic surgery after thoracoscopic esophagectomy from January 2014 to April 2015 were analyzed .All patients were divid-ed into single-lumen endotracheal intubation (group A)and double lumen endotracheal intubation group (group B).The endotracheal intuba-tion time,operation time,incidence of pulmonary infection,intraoperative and postoperative PaO2,PaCO2,incidence of anastomotic fistula, hospitalization expenses ,length of hospital stay and the incidence of postoperative chylothorax between two groups were compared .Results The difference in intraoperative PaO2,PaCO2,incidence of pulmonary infection,endotracheal intubation time,operation time,hospitalization days and the hospitalization cost between two groups were statistical significance .The difference of the rest index between two groups were no statistical significance.Conclusion Group A has certain advantages in perioperative management ,hospitalization cost and so on,but has disadvantages in perioperative hypoxemia and carbon dioxide retention and acid -base balance disorders .

Objective To investigate the prevalence of metabolic syndrome (MS) among residents in Shuimogou district of Urumqi city and to compare the differences between the Uygur and Han Populations. Methods Adopting cluster sampling, a survey of diabetes mellitus was conducted in Shuimogou district in June, 2008. Data of total 2420 subjects aged over 18 years with complete data, including background information of each individual, blood pressure, lipid profile, blood glucose and so on, were analyzed in this study. The criterion of the China Diabetes society (CDS) in 2004 was applied for diagnosis. Results The crude prevalence rates of MS were 12.85% in total, 14.91% in male and 7.39% in female, respectively. The age-standardized prevalence rates of MS were 9.93% in total, 13.58% in male and 6.11% in female. The prevalence rates of MS in male was higher than that in female (P0.05). The prevalence rates of components of MS were 43.31% for obesity, 30.08% for hypertension, 25.79% for hypertriglyceridemia and 16.28 % for hyperglycosemia. Among the four factors above, there were about 65% subjects who had at lest one abnormal factor according to the CDS criterion. Conclusion There were no differences in the prevalence rates of MS between the Uygur and Han populations. However, the prevalence rate of MS in male was higher than that in female. More than half subjects had at least one abnormal metabolic factor.

Objective To investigate the value of plasma H-FABP level and Acute Physiology and Chronic Health Evaluation(APACHE Ⅱ) in severity and prognosis estimation for patients with acute pumonary embolism(APE).Methods Totally 160 APE patients were hospitalized from January 2010 to January 2015 and enrolled in this study.According to the severity of the disease,these patients with APE were divided into low-risk group,moderate-risk group and high-risk group.According to clinical prognosis,these patients with APE were divided into survival groups and death groups.Plasma levels of H-FABP were measured by enzyme linked immunosorbent assay(ELISA),and APACHE Ⅱ score were analyzed.The differences of Plasma H-FABP levels and APACHE Ⅱ score were compared and which the relationship with severity and the prognosis of APE were also assessed.Results With the increased severity in patients,the H-FABP and APACHE Ⅱ score were significantly increased (P ＜ 0.05);the H-FABP and APACHE Ⅱ score were significantly higher in death group as compared with survival group(P ＜0.05).The H-FABP levels and APACHE Ⅱ score were positive correlated(r =0.71,P =0.000).ROC curves analysis results showed that the area under curve of H-FABP was 0.854 (95 ％ CI:0.784-0.927),and optimal operating point (OOP)was 13.3 μg/L,which had 81.0％ sensiticity and 79.4％ specificity;ACU of APACHE Ⅱ was 0.861 (95％ CI:0.812-0.932),and OOP was 19.2,which had 77.8％ sensiticity and 80.4％ specificity.The AUC was 0.914 (95％ CI:0.825-0.948),and the sensitivity was 88.9％,specificity was 87.6％ when the two cutoff values were both achieved,which were higher than the single H-FABP and APACHE Ⅱ score.Conclusion The H-FABP and APACHE Ⅱ score can effectively assess severity and prognosis of APE patients,meanwhile,it provide an objective basis for the clinical individual treatment and reducing the mortality rate of APE patients.

Objective To probe the cause,clinical and imaging findings of children's congenital pyriform sinus fistula (CPSF). Methods Clinical and radiographic data in 23 patients with children’s CPSF were analyzed retrospectively which were confirmed by pathology.Results 1 6 patients represented repeated swelling and pain in left anterior neck,6 of whom were misdiagnosed as thyroid abscess and suffered surgery.7 patients represented masses in left anterior neck.Ultrasound showed all patients with diffuse en-larged thyroid gland with uneven mass and separated liquid dark space or infection in deep neck soft tissue,and no CPSF was identi-fied.The subsequent esophageal barium meal confirmed the fistula in 8 patients,and other patients underwent further CT scan with image post-processing.CT showed clear fistula in 4,suspicious fistula in 7 and no fistula in 4,All fistulas were confirmed by the pa-thology.Conclusion The combination of ultrasound,esophagogram and CT with image post-processing can improve the diagnostic sensitivity and accuracy of CPSF.

Objective: To search for the weighting the doctor’s service value and method to give the payment to doctors. Methods:From the hierarchy of medical service items, medical service items are classified, the weight of medical service item are calculated by analytic hierarchy process (AHP) , the Harvard University doctor workload measurement model is established. Results: According to the weight of medical service items, to calculate the workload of doctors integrated with practical work quantity. Conclusion:By applying the theoretical results into practices, the estimation system of doctor workload was smoothly operated in the organization.

Objective To perform Low dose dynamic MSCT( multi-slice CT) in sleeping obstructive sleep apnea syndrome ( OSAS) patients correcting the imprecise measure values in waking state, and to exactly analyse the location and extension of the dynamic changes about the condition. Methods Sixteen OSAS patients were scanned both in waking and naturally sleeping period ( end phase of inspiration and expiration). Measured at the narrowest part of the retropalatal ( RP) and retroglossal ( RG) and 5 mm under the tip of epiglottis at the epiglottal ( EPG) at the end period of inspiration in sleeping, respectively, and compared the accurate pos(?)on of the narrowest or occlusive level in 3 phases. All patients were also scanned using cine mode at the narrowest level at the end period of inspiration in sleeping to show the pharyngeal cavity changes during sleep. Results The smallest XSA of RP region (Mw = 47. 50 mm2 ,Me =73. 00 mm2 , Mi =2. 00 mm2 ;Zwe =2. 897,Pwe =0. 003 ;Zwi =4. 192,Pwi