Objective To detect the changes of serum lipid levels in diabetic peripheral neuropathy patients,investigate the relationship between ApoB and HOMA-IRI and diabetic peripheral neuropathy.Methods One hundred and eighty-two patients with type 2 diabetes mellitus admitted to the medical department of Xuanwu Hospital Capital Medical University from January 2015 to August 2016 were enrolled in this study.All patients underwent EMG detection,the MCV of bilateral median nerve,tibial nerve and common peroneal nerve,and the SCV of median nerve,ulnar nerve and sural nerve.According to the detection results and symptoms and signs,the subjects were divided into type 2 diabetic peripheral neuropathy group (DPN,86 cases) and type 2 diabetic non peripheral neuropathy group (NDPN,96 cases).The general demographic data of the two groups was recorded,including TC,TG,HDL-C,LDL-C,FBG,HaBlc,FINS,UA,UAE and HOMA-IRI,to analyze the relationship between the nerve conduction velocity in type 2 diabetes patients with peripheral neuropathy and HDL-C,LDL-C,FINS,HbAlc,ApoB,HOMA-IRI.Results The course of disease in patients with type 2 diabetic peripheral neuropathy ((9.53 + 2.38) years,UAE (22.24) mg/L) was higher than that in patients with type 2 diabetic non peripheral neuropathy ((6.37 + 1.59) years and UAE (9.83) mg/L);FINS and HOMA-IRI levels in the DPN group were lower than those in the NDPN group ((16.33±2.33) vs.(35.16±5.02),4.94 vs.15.27,t=10.629,4.459,31.842,3.128,P<0.05);the level of TG,LDL-C and ApoB in patients with type 2 diabetic peripheral neuropathy was higher than those in patients with type 2diabetic non peripheral neuropathy,and the difference was statistically significant (P<0.05);the disorder of lipid metabolism in the DPN group was serious,whose occurrence rate was higher compared with the NDPN group (P<0.05);the MCV of median nerve was negatively correlated with ApoB (r=-0.278,P=0.041),SCV was positively correlated with HDL-C (r=0.425,P=0.002);MCV of tibial nerve was positively correlated with HDL-C (r=0.335,P=0.031),SCV of ulnar nerve was positively correlated with HDL-C (r=0.425,P=0.004) and FINS (r=0.387,P=0.006),negatively correlated with HOMA-IRI (r=-0.405,P=0.008);sural nerve SCV was positively correlated with HDLD-C (r=0.532,P=0.001),and HbAlc (r=-0.383,P=0.005),negatively correlated with LDL-C (r=-0.361,P=0.018).Conclusion Nerve conduction velocities in patients with type 2 diabetic peripheral neuropathy were associated with HDL-C,LDL-C,FINS,HbAlc,ApoB,and HOMA-IRI.

Objective To investigate clinical characteristics of cerebral blood perfusion in patients with T2DM and T2DM accompanied with hypertension.A part of the patients were studied on the metabolism of cerebral galactoside. Methods 99mTc-ECD was injected into 77 patients diagnosed as T2DM,and SPECT imaging of the cerebral cortex was done. And also 18 F-FDG imaging of the cerebral cortex was done in twelve of them. Results In T2DM patient the radioactivity was decreased in the temporal lobes of the cerebral cortex. Conclusion Our investigation demonstrates that although some older T2DM patients do not suffer from brain vascular accidents, all of them have a decreased cerebral blood perfusion and decreased cerebral metabolism. The early checked cerebral blood perfusion and metabolism may be important for these patients.

o statistical difference between WMD group and control group (t = 1.83, t = 0. 88, P 0. 05). Conclusion Conventional MRI is able to quantify the brain maturation and prognosis of premature infants using TMS.

OBJECTIVE: To explore the association of XRCC3 gene polymorphisms and haplotypes with laryngeal. METHOD: We selected 4 tag SNPs (rs12432907, rs861536, rs861537, rs861531, rs861531) for the present study. 310 laryngeal patients and 310 healthy control subject were genotyping. The distribution of genotypes and haplotypes in these two group was compared. RESULT: The distributions of rs12432907 was significantly different between these two groups. The CCAG haplotype frequency was higher in laryngeal group than that in control group. But TCAG and TTAG haplotype frequency was were lower in the laryngeal patient than that those in the control subject. CONCLUSION XRCC3 gene polymorphism was associated with the risk of laryngeal patients.
Case-Control Studies ; DNA-Binding Proteins ; genetics ; Genotype ; Haplotypes ; Humans ; Laryngeal Neoplasms ; genetics ; Polymorphism, Single Nucleotide

For a valid control of the finance management, the management system is developed again aiming at finance related control links and key control points. In this way, the control is rigorous and integral with simple procedures for check and examination. The key control point is set oriented to note management. Real-time operation is controlled. Post output processing is controlled. With business income and business expenditure as the main line, the control process of the related links are built up. Computer maintenance system is controlled.

Keratoconus is a progressive, non - inflammatory corneal thinning disorder that produces a unique spectrum of change in the surface curvature of the cornea. The suspected factors associated with the cause of keratoconus include genetic mechanisms, familial associations, allergy, atopy and so on, but environmental factors, such as abnormal rubbing, contact lens wearing and ultraviolet radiation may be easily ignored. Although it is commonly thought that keratoconus is a result of various pathological progress mediated by multiple factors, those chronic trauma could play important roles in the pathological progress. The classic definition of keratoconus is still referred as a non - inflammation disorder with malnutrition of keratectasia, more and more clinical evidences and experimental results that may refute this concept. It may be due to the long-term persistent chronic trauma resulted from eye rubbing, contact lens or ultraviolet radiation. Under this conditions, the increased release of inflammatory mediators and matrix metalloproteinases may accelerate keratocyte apoposis and enzyme metabolism disorders, with the result of matrix cell lost, tensile strength decreased and keratectasia. Here, for some papers known about the relationship between chronic cornea trauma and keratoconus were reviewed and discussed its possible causal relationship.

Objective To explore cardiac function of ventricular contraction and drastole in 30 infants with severe pneumonia in high altitude area.Methods Thirty patients with severe pneumonia were collected as patient group,and 32 healthy as control group.Cardiac function of left and right ventricle were detected by echocardiography,and the results were compared between two groups.Results Pre-ejectin period/acceleration time(RPEP/AT) of the right ventricle,right isovolumic relaxation time(RIRT) and left isovolumic relaxation time(LIRT)were significantly longer in patient group than those in control group(Pa

Objective To investigate the effect of comprehensive rehabilitation on the stroke.Methods 120 cases of stroke divided into rehabilitation group(60 cases)and control group(60 cases).They were assessed with Fugl-Meyer Assessment(FMA),Modified Barthel Index(MBI),and Satisfaction with Life Scale(SWLS)before and 1 month,3 months and 6 months after treatment respectively.Results The scores of FMA,MBI and SWLS were improved significantly in rehabilitation group,especially in the 1st month,while that of control group presented the tendency of decline.Conclusion Comprehensive rehabilitation is effective on motion function,activity of daily living and quality of life of stroke patients.

Central Nervous System Diseases ; complications ; virology ; Child ; China ; epidemiology ; Enterovirus ; Enterovirus A, Human ; Female ; Hand, Foot and Mouth Disease ; complications ; epidemiology ; Humans

BACKGROUND: Ginsenoside Rb1 has been extensively used in the protection and treatment of heart, encephalon, lung, kidney and liver damage. However, its application in skin flap is rare.OBJECTIVE: To investigate the effects of intraperitoneal injection of ginsenoside Rb1 on the survival of the dorsal random-pattern skin flap with large length-to-width ratio in rats.METHODS: Healthy adult SD rats were randomly divided into experimental and control groups. A caudally based dorsal random pattern skin flap, 80 mmx20 mm (length: width = 4:1), was symmetrically made. Ginsenoside Rb1 (2 mg/kg) was intraperitoneally injected into the experimental group rats, and the same volume of normal saline was injected into the control group. Malonyl dialdehyde (MDA) and nitric oxide (NO) level of the flaps were tested 1 day after operation; the amount of viable tissues of the flaps were examined by planimetry 10 days after operation. Specimens from the proximal, middle and distal flaps were harvested for HE staining to examine the microstructure.RESULTS AND CONCLUSION: At the first day after operation, NO level was higher in the experimental group than the control group (P< 0.01), while MDA level was lower than the control group (P< 0.01). At the 10th day after operation, the survival rate of the flap was significantly greater in the experimental group than the control group (P < 0.001). Histological observation showed that compared with the control group, the edema and inflammatory cells infiltration were less, while the fiber hyperplasia and the microvascular growth were more obvious in the experimental group. Results show that intraperitoneal injection of ginsenoside Rb1 can enhance the blood supply of the flaps and improve the survival of the random-pattern skin flaps with large length-to-width ratio in rats. This may involve its effects of improving NO activity, decreasing lipid peroxidation, and promoting angiogenesis of skin flaps.