1.Analysis of complexity in Chinese meteria medica industrial chain.
Ying LIU ; Qi LI ; Xiao-Fan WANG
China Journal of Chinese Materia Medica 2014;39(16):3187-3191
Chinese meteria medica (CMM) chain is a long-span chain covering agriculture which mainly depends on the forces of nature as well as high-tech CMM industry, CMM expertise industry and fast developing CMM circulation industry. Imbalance among the development of these industries produces bottlenecks and hinders the operation of the entire production chain. After analyzing the structure of Chinese meteria medica industrial chain from the perspective of national economy industry, three industry classifications and differentiation of factor intensity, we conclude that the complex structure of CMM industry chain is attributable to these three aspects. And the complexity is mainly shown at complex industry, varied product types, different coordination of various industrial sections and different technical growth speed of varied industry. We propose that structural complexity is the natural property of the chain, which is the main reason of industry sector development imbalance and bottleneck. Results of this research could provide theoretical analysis for future research on the coordination of industrial chain and the efficiency of resource allocation.
China
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Drug Industry
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economics
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standards
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Medicine, Chinese Traditional
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economics
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standards
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Plants, Medicinal
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chemistry
2.Establishment and analysis of three-dimensional finite element model based on tail-suspended rat experiment
Qi LI ; Wentao JIANG ; Yubo FAN
Chinese Journal of Tissue Engineering Research 2009;13(39):7657-7660
By using three-dimensional finite element analysis method, the necessity of tail joints in the establishment of finite model specifically for the widely used tail-suspended rat experiments in weightlessness simulation was explored. A weightlessness tail-suspended three-dimensional finite element rat model was established using CT scan and Abaqus software, and the computation and analysis were conducted using the same model. The stress distribution and displacement in tail, lumbar spine, pelvis and femur of a tail-suspended rat both with and without cartilage were simulated and calculated.The results showed that stress distribution and displacement of tail-suspended rat were quite different between rats with cartilage and without cartilage, which affected the calculation precision of the model. Accordingly the consideration of articular cartilage in establishing the tail-suspended three-dimension finite element rat model is quite necessary,In addition, the asymmetry of pelvis stress distribution of tail-suspended rat suggests that the degree of balance of tail-suspended rat will affect the stress distribution in rats.
3.Discussion to the Definition and Classification of Complementary Therapies in MeSH
Qi XIE ; Weiyu FAN ; Shasha LI
International Journal of Traditional Chinese Medicine 2009;31(5):445-447
MeSH is a controlled vocabulary developed by U.S. National Library of Medicine. It is used for indexing articles for MEDLINE/PubMed or building search strategies for medical literatta-e retrieval. MeSH terminology provides information on how TCM being understood and accepted by western medicine, with the time when the terms added in, the scope notes, and hierarchical structure of terms in the category of Complementary Therapies. This article thoroughly discussed the definition and classification of complementary therapies in MESH.
4.Three-dimensional finite element analysis of uncemented and cemented femoral prostheses implanted under different bone densities
Shuqiang LI ; Dongsong LI ; Xin QI ; Honghui FAN ; Jianguo LIU
Chinese Journal of Tissue Engineering Research 2009;13(9):1785-1788
BACKGROUND: During the hip replacement, selection of prosthesis often depends on patients' bone condition. There has been no gold standard for selection of prosthesis. It will be of scientific significance to select femoral prostheses implanted under different bone densities through three-dimensional finite element analysis and simulated contrast mechanical tests.OBJECTIVE: Three-dimensional finite element analysis was employed to select femoral prostheses according to different bone densities, and simultaneously simulated contrast mechanical tests were performed to determine the age criteria regarding the selection of femoral prosthesis during the hip replacement.DESIGN, TIME AND SETTING: An open experiment was performed at the Second Department of Orthopedics, First Clinical Hospital of Jilin University and Institute of Biomechanics, Jilin University between September 2006 and May 2007.MATERIALS: Freshly adult femoral specimens were harvested from cadavers.METHODS: Three-dimensional finite element models of femur were established using Solidworks software. Following the known formula, the bone density and elastic modulus at different age brackets were calculated and input into the computer. The human one-foot standing condition was simulated and pressure was loaded on the reconstructed femoral models.MAIN OUTCOME MEASURES: Some biomechanical characteristics of uncemented and cemented femoral prostheses, such as the distress distribution and initial micromovement at different bone densities, were measured.RESULTS: Relatively well-distributed whole distress and slight initial micromovement of uncemented femoral prostheses were found in male patients at 30-60 years old and in female patients at 40-55 years old. Symptoms of cemented femoral prostheses the same as the uncemented femoral prostheses were present in male patients at 60-70 years and in female patients older than 55 years old.CONCLUSION: Results of three-dimensional finite element analysis and simulated contrast mechanical tests suggest that uncemented femoral prostheses provide better therapeutic effects in male patients younger than 60 years and in female patients younger than 55 years than cemented femoral prosthesis.
5.Clinical observation on the treatment of chronic heart failure with Qiliqiangxin capsule
Ruyi LI ; Yakun FAN ; Yingxiao LI ; Xiaoyong QI
International Journal of Traditional Chinese Medicine 2010;32(5):409-410
Objective To investigate the influence of Qiliqiangxin capsule on the exercise tolerance in patients with chronic heart failure. Methods 86 patients with chronic heart failure were selected and recruited into a control group and an observation group randomly. The patients in the control group were given angiotensin-converting enzyme inhibitor, diuretic,carvedilol or metoprolol and dixina. The patients in the observation group were given Qiliqiangxin capsule on the basis of the control group. The change of exercise tolerance and left ventricular ejection fraction in all patients were detected after 4 weeks.Results The distance of walking in 6 minutes increased for all patients after 4 weeks' treatment(P<0.05), while the observation group increased more significantly than the control group(P<0.05). The left ventricular ejection fraction increased for all patients after therapy 4 weeks (P<0.05), while the observation group increased more obviously than the control group (P<0.05). The total excellent rate and effective rate in the observation group were both higher than the control group (P<0.05). Conclusion Qiliqiangxin capsule can increase the clinic curative effect by increasing the exercise tolerance and improving the heart function of patients with chronic heart failure.
6.Evaluation of Tubal Patency with Transvaginal Three-dimensional Hysterosalpingo-contrast Sonography.
Qi CHENG ; Sha-sha WANG ; Xian-sheng ZHU ; Fan LI
Chinese Medical Sciences Journal 2015;30(2):70-75
OBJECTIVETo investigate diagnostic efficacy of transvaginal three-dimensional hysterosalpingo-contrast sonography (3D-HyCoSy) in assessing tubal patency with chromolaporoscopy.
METHODSA total of 157 infertile women underwent 3D-HyCoSy to evaluate tubal patency. Among these patients, 39 patients were also examined by chromolaporoscopy. The concordance of the two clinical assessment methods was analyzed by the Kappa coefficient test.
RESULTSAmong the 306 oviducts examined by 3D-HyCoSy, 99 (32.4%) were patent, 126 (41.2%) partially obstructed, and 81 (26.5%) completely obstructed. Diagnostic results with 3D-HyCoSy were not statistically different from those obtained in the 39 women (78 oviducts) who also underwent chromolaporoscopy, and the two methods showed a high concordance (k=0.747, P=0.000). The 3D-HyCoSy procedure had a sensitivity of 84.8% (28/33), a specificity of 96.2% (25/26), and positive and negative predictive values of 93.3% (28/30) and 86.2% (25/29) respectively.
CONCLUSIONTransvaginal 3D-HyCoSy can accurately reveal the spatial path and morphology of the oviduct and is a safe and effective method to evaluate tubal patency.
Contrast Media ; Fallopian Tube Patency Tests ; methods ; Fallopian Tubes ; diagnostic imaging ; Female ; Humans ; Hysterosalpingography ; Imaging, Three-Dimensional ; Infertility, Female ; diagnostic imaging ; Laparoscopy ; Ultrasonography
8.Regulation of activated genes of fibroblasts and their improvement of skin aging
Yuqing QI ; Tianhang LI ; Liyun FAN ; Quanzhong LIU
Chinese Journal of Medical Aesthetics and Cosmetology 2013;(1):43-46
Objective To investigate the possible mechanisms using different chemicals to improve the skin aging by the effect of estrogen,vitamin E,vitamin C on the transcriptional level of MMP-1 and HAS-2 mRNAs in cultured human skin fibroblast in vitro.Methods The different concentrations of estrogen,vitamin E,vitamin C were put into cultured human skin fibroblasts.After 24 hours,RT-PCR was used to detect the effects of the different chemicals on the transcriptional levels of the HAS-2 and MMP-1 mRNAs in fibroblasts.Results The effects of estrogen and vitamin C on the MMP-1 mRNA had significant difference between the high dose group and blank control group,and between the low dose group and blank control group (P<0.05) ; the difference between the low dose group and high dose group was not statistically significant (P>0.05).The effects of vitamin E and vitamin C on Has-2 mRNA also had significant difference between the high dose group and the blank control group,and between the low dose group and blank control group (P<0.05),but the difference between the low dose group and high dose group was not statistically significant (P>0.05).Conclusions Estrogen and vitamin C can reduce the transcription of MMP-1 gene,which decreases the degradation of collagen in the skin; vitamin E and vitamin C can increase the transcription of HAS-2 gene,which may possibly increase the synthesis of hyaluronic acid to alleviate the skin aging.
9.The Present Status on Classification of Phytoplasmas
Fan LAI ; Yong LI ; Qi-Cong XU ; Guo-Zhong TIAN ;
Microbiology 1992;0(02):-
The history and present status of phytoplasma classification are introduced briefly in this paper.The newly classification methods and rules for the description of Candidatus species are reviewed.The key problems and direction on the classification and identification of phytoplasmas in China are discussed.
10.Morphology and hemodynamics in acute Stanford type B aortic dissection: quantification by MRI
Yu LI ; Zhanming FAN ; Zhaoqi ZHANG ; Ting QI ; Kui YING
Chinese Journal of Radiology 2008;42(4):363-367
Objective To analyse the flow characteristics in the true lumen and false lumen,and the relationship between the flow characteristics and the collapse degree of the true lumen using MRI.Methods Eleven patients with acute Stanford type B aortic dissection were examined by true FISP、3D CE MRA、PC cine MRI on a Siemens Sonata 1.5 T.Not only the quantitative data on the hemodynamics such as peak velocity,average velocity,average flow volume,forward volume,retrograde volume and net volume,and the area of the true lumen and false lumen can be acquired,but also the blood flow model,ie the velocity-mapping.Then we analysed the relationship between the flow characteristics and the collapse degree of the true lumen.Results The average area of the false lumen in the proximal descending aorta(about 2 cm distal to the entry)was(8.10±2.93)cm2,and(2.59±0.93)cm2 of the true lumen in the same slice (P<0.05).The average velocity in the false lumen,(2.81±0.73)cm/s,was significantly lower than in the true lumen[(15.52±2.84)cm/s,P<0.01],wheras the average flow(36.32±5.37)ml/s,was not significantly difierent(P>0.05)from the average flow in the false lumen(37.62±24.58)ml/s.The velocity-mapping curve looked like same in the true and false lumen in this level.And in the abdominal aorta(about the level of the hepatic hilar),the average flow(10.46±5.57)cm/s was significantly lower(P<0.05)than in true lumen[(4.04±2.96)cm/s].At this level,the direction of blood flow in the true lumen was retrograde(upward)in the mid and late systolic phase in six patients,and normal in the diastolic phase and early systolic phase,that was to say,bidirectional blood flow can be caught in the true lumen of the abdominal aorta.The collapse degree of the true lumen was closely correlated with the the average velocity and the flow volume in the false Iumen,and the coefficient correlation and P value were 0.931 and 0.000,0.926 and 0.000 respectively.Conclusions PC cine MRI can quantitatively measure the peak velocity,average velocity,average flow volume,forward volume,retrograde volume and net volume,and combined with 3D CE MRA can evaluate the collapse degree of the true lumen.It is important for clinical application in the diagnosis,therapeutic management and the therapeutic opportunity choice of the acute Stanford type B aortic dissection.