Objective To compare the prevention effect of atrial fibrillation recurrence in hypertensive patients by telmisartan versus nifedipine.Methods Ninety-eight cases of hypertensive with paroxysmal atrial fibrillation patients were enrolled and divided into telmisartan group and nifedipine group with 49 cases each by random digits table method.Telmisartan group was given telmisartan 80 mg/d,nifedipine group was given nifedipine 30 mg/d.Dose of the drug needed to be adjusted according to individual condition until achieving the target.Followed-up for 18 months.Observed two groups of recurrence of atrial fibrillation and the recurrence time for the first time,recorded before and after the treatment of cardiac parameters:including left atrial diameter (LAD),left ventricular end diastolic diameter(LVDD),left ventricular posterior wall thickness (LVPWT),interventricular septum thickness (IVST),left atrial volume index(LAVI) and left ventricular mass index(LVMI).Results The blood pressure after treatment in two groups was lower than that before treatment,there was statistically significant difference (P＜ 0.05),but there was no statistically significant difference between two groups (P ＞ 0.05).After treatment,the recurrence of atrial fibrillation,atrial fibrillation recurrence time for the first time in two groups had no statistical significance (P ＞ 0.05).But the incidence of persistent atrial fibrillation in telmisartan group was significantly lower than that in nifedipine group [4.1％ (2/49) vs.16.3％ (8/49)],there was statistically significant difference (P =0.045).The cardiac parameters between two groups before treatment had no significant difference (P ＞ 0.05).After treatment,the cardiac parameters in two groups were signifcantly reduced,there were statistically significant differences (P ＜ 0.05).Moreover,the LAD,LVPWT,LAVI and LVMI in telmisartan group after treatment were significantly lower than those in nifedipine group [(37.6 ± 2.9) mm vs.(38.9 ± 2.4) mm,(11.6 ± 1.0) mm vs.(12.0 ± 0.9) mm,(22.0 ± 3.6) ml/m2 vs.(23.9 ± 4.2)ml/m2,(120.4 ± 18.2) g/m2 vs.(129.5 ± 19.2) g/m2],there were statistically significant differences (P ＜ 0.05).Conclusions Nifedipine and telmisartan can effectively lower the blood pressure.But telmisartan is superior to preventing atrial fibrillation recurrences and developing in hypertensive with paroxysmal atrial fibrillation patients,promoting cardiac parameters and postponing myocardial remodeling.

OBJECTIVE:To observe the clinical efficacy of Compound jianghuang decoction in preventing nonproliferate diabetic retinopathy(NPDR) from developing into proliferate diabetic retinopathy(PDR).METHODS:The clinical data of 123 patients(208 eyes) with NPDR receiving Compound jianghuang decoction(n = 64 cases,treatment group) or low dose of enteric - coated aspirin(n = 59,control group) in addition to hypoglycemic drugs administered in both groups to control blood sugar level were analyzed retrospectively.The clinical efficacy in the two groups was observed by fundus examination and fundus fluorescein angiography.RESULTS:The proportion of developing into PDR in the treatment group was significantly lower than in the control group.CONCLUSION:Compound jianghuang decoction is effective in suppressing retinal neovascularization and preventing NPDR from developing into PDR.

Competitive fluid phase radioimmu-noassay was conducted with eightanti-apoB-100 monoclonal antibodieswhich had been established in our laboratory.We found thatthere were at least three differenttypes of epitopes on the hydratedsurface of the lipoproteins-VLDL,IDL and LDL.These observations were of certainsignificance in studies on antigenicstructures of apoB,as well asassays for apoB in various fractionsof lipoproteins.

Cell culture medium is one of the essential raw materials in the field of life and health.In recent years,the performance and quality of domestic cell culture media have been improving,and the market share of domestic vendors has steadily increased from 19.2% in 2017 to 33.7% in 2021.However,there are also some problems and shortcomings in industrial development,mainly including:technology and process accumulation need to be strengthened;product quality need to be improved;lack of industry standards and norms.Based on literature research,special topic discussion and expert interview,this paper reviews the development history of cell culture medium,deeply analyzes and systematically combs the opportunities and challenges faced by the industry development from the basic situation,current situation and trend of the development of cell culture medium industry in China,and puts forward relevant countermeasures and suggestions.

OBJECTIVETo analyze the factors in the non-operative treatment of cervical spinal cord injury without fracture or dislocation.

METHODSThe clinical data of 122 patients with cervical spinal cord injury without fracture or dislocation from January 2009 to December 2012 treated by non-operative treatment were retrospectively reviewed. There were 84 males and 38 females, aged from 18 to 83 years with an average of (52.37 +/- 13.27) years. The clinical features, such as age, gender, cause of injury, time from injury to treatment, ASIA grade of spine cord injury, MRI type of spine cord injury, range of spine cord injury, effective cervical spinal canal ratio, Pfirrmann grade of intervertebral disc herniation, segment of intervertebral disc herniation, intervertebral disc ligament complex injury, treatment of high-dose methyiprednisolone, were observed. Single factor and multiple factor Logistic regression analysis were used in the clinical data in order to analyze the influencing factors of above items to prognosis.

RESULTSFor univariate analysis, the factors such as MRI type of spine cord injury, extent of spine cord injury, effective cervical spinal canal ratio, Pfirrmann grade of intervertebral disc herniation, segment of intervertebral disc herniation, ASIA grade of spine cord injury, associated with prognosis (P < 0.05). Multiple linear regression analysis showed that the main prognostic factors including MRI type of spine cord injury, range of spine cord injury, effective cervical spinal canal ratio, Pfirrmann grade of intervertebral disc herniation, ASIA grade of spine cord injury according to its effective intension (P < 0.05).

CONCLUSIONThe main prognostic factors on non-operative treatment of cervical spinal cord injury without fracture or dislocation were MRI type and extent of spine cord injury, meanwhile, correlate with effective cervical spinal canal ratio, Pfirrmann grade of intervertebral disc herniation, ASIA grade of spine cord injury. It is deliberative to choose no-operative treatment, for it only refers to the patients with the mild localized edema type or no signal change of spinal cord in MRII. Operative treatment shoud be recommended for other patients.

Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cervical Cord ; diagnostic imaging ; injuries ; surgery ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prognosis ; Radiography ; Retrospective Studies ; Spinal Cord Injuries ; diagnosis ; diagnostic imaging ; surgery ; Young Adult

Objective To compare the clinical effect of three different methods in treatment of premature.Methods 150 premature patients were randomly divided into three groups,50 cases for each group,received treatments with ritodrine,magnesium sulfate plus salbutamol,or magnesium sulfate alone respectively. The tensity of uterine contraction, the interval between drug administrations and the relief of uterine contraction, the accumulative drug using time, the elongated pregnancy durations were observed for the dertermination of effectiveness. Results The group treated with ritodrine, magnesium sulfate plus salbutamol or magnesium sulfate were effective in 94%, 78%,70% of patients of each group, and it showed that ritodrine was more effective than the combination and magnesium sulfate. The intervals of drug using and contraction relief were statistically different among three groups, (2. 16 ±0. 91)h,(4. 14 ± 1.07)h,(5.12 ± 1.45) h for each(all P ＜0.05).The cumulative drug using times were(7. 04 ±1. 16) d, (7.46 ± 1.20) d, (7.06 ± 2.78) d for three groups and proved not to be statistically significant ( all P ＞0. 05 ). The elongated pregnancy durations were (22.08 ± 7.32 ) d, ( 17.42 ± 5.85 ) d and ( 11.82 ± 5.04 ) d, and significantly different in three groups ( all P ＜ 0. 05 ). Conclusion The treatment of premature with ritodrine or the combination of magnesium sulfate and salbutamol was superior to using magnesium sulfate alone.

Hydrogen sulfide (H2S) was considered as the third gasotransmitter,along with nitric oxide and carbon monoxide,with extensively biological activities.Considerable evidence showed that H2S was involved in inflammatory processes such as in inflammatory cells,inflammatory mediates,vascular tension and signaling pathways.Previous studies suggested H2S played a bidirectional role in regulating inflammation including pro- and anti-inflammatory actions due to different animal models.Further study about the role and mechanism of H2S in inflammation will contribute to efficient prevention and treatment for inflammatory diseases.

Gastrointestinal stromal tumors are the most common mesenchymal neoplasms deriving from the gastrointestinal tract.The prediction of its biological behavior has become a new hot spot of the research.This article reviewed the studies on predicting the biological behavior of gas trointestinal stromal tumors.