Objective To investigate the psychological resilience in the family members of children with cryptorchidism and to explore relevant influencing factors so as to provide a basis for enhancing the family members' psychological resilience and disease response capacity.Methods The family members of totally 186 children with cryptorchidism who received surgery between July 2012 and December 2016 were selected by convenience sampling. The family members' general info, level of social support and psychological resilience were then investigated. And statistical methods adopted in this study included χ2 test, descriptive analysis, Pearson correlation analysis and multivariate hierarchical regression analysis.Results Totally 101(54.9%) out of the 184 family members showed good psychological resilience; 60(32.6%) of them showed bad psychological resilience,and 23 (12.5%)of them showed the worst psychological resilience. There was statistically significant difference in psychological resilience between the family members with different education background, profession, monthly income, address and social support (χ2=10.272, 27.889, 11.425, 12.521, 12.873;P<0.05), and education background, profession, monthly income and social support were major influencing factors of psychological resilience (R2=0.659;F=32.875,P<0.001).Conclusions The poorer education background, social support, monthly income, living environment and working conditions the family members have, the worse their psychological resilience is. Therefore, we need to pay more attention to family members with poor education background, social support, monthly income, living environment and working conditions so as to enhance their psychological resilience and disease response capacity.