1.An experimental study to increase the fertilizing capacity of human gamates(sperm) and its clinical application.
Korean Journal of Obstetrics and Gynecology 1991;34(8):1118-1124
No abstract available.
Humans*
2.Male factor infertility and in vitro fertilization-embryo transfer.
Sun Haeng KIM ; Rae Hwan JUNG ; Pyong Sahm KU
Korean Journal of Fertility and Sterility 1992;19(1):71-79
No abstract available.
Humans
;
Infertility*
;
Male*
3.GnRH analogue in controlled ovarian hyperstimulation for gonadotropin poor responder.
Sun Haeng KIM ; Hee Kyung LEE ; Pyong Sahm KU
Korean Journal of Fertility and Sterility 1993;20(1):37-43
No abstract available.
Gonadotropin-Releasing Hormone*
;
Gonadotropins*
4.Efficacy and safety of nafarelin in the treatment of endometriosis.
Pyong Sahm KU ; Tak KIM ; Young Tae KIM
Korean Journal of Obstetrics and Gynecology 1992;35(12):1759-1767
No abstract available.
Endometriosis*
;
Female
;
Nafarelin*
5.A Study of a Molecular Variant of Angiotensinogen Associated with Korean Pregnancy-Induced Hypertension.
Young Tae KIM ; Pyong Sahm KU ; Min Soo LEE
Korean Journal of Obstetrics and Gynecology 1997;40(1):66-70
Pregnancy-induced hypertension(PIH) is one of the major causes of maternal, fetal and neonatal morbidity and mortality. Although many causes are encountered, etiology of PIH is still unknown. A molecular variant of angiotensinogen, M235T, reported to be linked with essential hypertension and PIH. This study was to evaluate the molecular variation of angiotensinogen in Korean pregnancy-induced hypertension. Our results did not provide any definite relation with the molecular variant of angiotensinase, M235T, and Korean PIH.
Angiotensinogen*
;
Female
;
Hypertension
;
Hypertension, Pregnancy-Induced*
;
Mortality
;
Polymerase Chain Reaction
;
Pregnancy
6.Two cases of perineal endometriosis at the site of episiotomy scar.
Han Woo LEE ; Jae Chull SHIN ; Yong Wook KIM ; Kyu Wan LEE ; Pyong Sahm KU
Korean Journal of Obstetrics and Gynecology 1991;34(1):139-143
No abstract available.
Cicatrix*
;
Endometriosis*
;
Episiotomy*
;
Female
7.DNA Ploidy and Mutant p53 and Rb Gene Expression in the Ovarian Tumors.
Yong Wook KIM ; Pyong Sahm KU ; Inn Sun KIM
Korean Journal of Obstetrics and Gynecology 1997;40(12):2717-2727
No abstract available.
DNA*
;
Genes, Retinoblastoma*
;
Ploidies*
8.A study of effects of Wang's tube in semen preparation.
Yong Tae KIM ; Yong Ook KIM ; Hae Jung KIM ; Sun Haeng KIM ; Joong Yol RHA ; Pyong Sahm KU
Korean Journal of Fertility and Sterility 1991;18(1):95-99
No abstract available.
Semen*
9.Prenatal sex determination using male-specific DNA(deoxyribonucleic acid) amplification in maternal peripheral blood.
Young Tae KIM ; Hye Kyung LIM ; Sun Haeng KIM ; Kyu Wan LEE ; Joong Yol RHA ; Pyong Sahm KU ; Min Soo LEE
Korean Journal of Fertility and Sterility 1993;20(3):295-300
No abstract available.
10.Suppression of Steroid Receptor Function by Retinoblastoma Protein in Breast Cancer Cell Line, MCF 7.
Joon SONG ; Sung Jin CHO ; Kyung Il LEE ; Sun Haeng KIM ; Jae Sung KANG ; Kyu Wan LEE ; Jin Yong LEE ; Pyong Sahm KU
Korean Journal of Obstetrics and Gynecology 1997;40(10):2269-2278
Cancer results from mutations that disrupt the harmonious checks and balances that regulate normal cellular growth and development. These mutations arise in two classes of interacting genes:those that facilitate cell growth and tumor formation(oncogenes), in which mutation or overexpression is oncogenic, and those that inhibit these processes(tumor supp-ressor genes) whose loss is oncogenic. The human retinoblastoma(Rb) protein, a tumor suppressor, acts as transcription factor or/and cell cycle regulator. Heterogenous expression of the Rb gene product contributes to the genesis of a diverse group of human neoplasma such as breast, prostate, small cell lu- ng, bladder carcinoma and leukemia. Its structural aberrations were observed in 25% of br- east tumor cell lines studied and 7% of the primary tumors, such as homozygous internal deletions and total deletion. These observations suggest that Rb protein is involved in bre- ast cancer development. Here we report that Rb protein represses steroid receptor function and its involvement of cell cycle process in human breast cancer cell line, MCF7 cells. 1. The overexpression of Rb protein repressed the steroid receptor function in breast cancer cell line, MCF 7. 2. When we introduced the mutant type Rb expression vector(deletion of exon 22), such repression was not observed. 3. By introducing E2F expression vector, the action of Rb protein was repressed. 4. Rb protein modulated the binding patterns of proteins to Kil-GRE site. 5. Flow cytometry analysis showed that Rb protein acts on G0/G1 stage of cell cycle process. These findings provide the molecular basis of breast cancer therapy using Rb protein.
Breast Neoplasms*
;
Breast*
;
Cell Cycle
;
Cell Line*
;
Cell Line, Tumor
;
Exons
;
Flow Cytometry
;
Growth and Development
;
Humans
;
Leukemia
;
MCF-7 Cells
;
Prostate
;
Receptors, Steroid*
;
Repression, Psychology
;
Retinoblastoma Protein*
;
Retinoblastoma*
;
Transcription Factors
;
Urinary Bladder
Result Analysis
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