1.A Recent Update of Clinical and Research Topics Concerning Adult Moyamoya Disease.
Jin Pyeong JEON ; Jeong Eun KIM
Journal of Korean Neurosurgical Society 2016;59(6):537-543
A better understanding of moyamoya disease (MMD), such as natural clinical course, surgical outcomes and research, has been obtained. This review article focuses on an giving an update for adult MMD in the Korean population. In this paper, we mainly discuss the results of our domestic investigations including meta-analysis, and related subjects from other countries.
Adult*
;
Hemorrhage
;
Humans
;
Ischemia
;
Korea
;
Moyamoya Disease*
2.Influence of Anesthesia Type on Outcomes after Endovascular Treatment in Acute Ischemic Stroke: Meta-Analysis
Chulho KIM ; Sung Eun KIM ; Jin Pyeong JEON
Neurointervention 2019;14(1):17-26
PURPOSE: To assess clinical and angiographic outcomes after endovascular treatment (EVT) in ischemic stroke patients according to anesthesia types (general anesthesia vs. conscious sedation). MATERIALS AND METHODS: A systematic literature review through an online data base between January 1990 and September 2017 was performed. A fixed effect model was used in cases of <50% heterogeneity. The primary outcomes were good clinical outcome at the 3-month follow-up and successful recanalization. A meta-regression analysis was done to estimate primary outcomes of log odds ratio (OR) on onset-to-puncture time (OTP) differences. Publication bias was determined using Begg’s funnel plot and additional the Trim and Fill method. RESULTS: Sixteen articles including 2,662 patients (general anesthesia, n=1,275; conscious sedation, n=1,387) were included. General anesthesia significantly decreased good outcomes than conscious sedation (OR, 0.564; 95% confidence interval [CI], 0.354–0.899). However, outcomes did not differ significantly in randomized controlled trials (RCTs; OR, 1.101; 95% CI, 0.395–3.071). Anesthesia type was not associated with successful recanalization (OR, 0.985; 95% CI, 0.787–1.233). General anesthesia increased the risk of mortality (OR, 1.532; 95% CI, 1.187–1.976) and pneumonia (OR, 1.613; 95% CI, 1.172–2.221), but not symptomatic intracranial hemorrhage (OR, 1.125; 95% CI, 0.767–1.652). The meta-regression analysis showed no linear relationship between OTP differences and log OR of good outcome (coefficient, 0.0004; P=0.95) or successful recanalization (coefficient, 0.0005; P=0.94), respectively. CONCLUSION: General anesthesia seemed to be associated with adverse clinical outcome after EVT. However, its efficacy was not demonstrated in RCTs. Successful recanalization did not differ according to anesthesia type. Studies using individual patient data based on further RCTs are necessary to elucidate anesthesia effect on procedural and clinical outcomes.
Anesthesia
;
Anesthesia, General
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Conscious Sedation
;
Follow-Up Studies
;
Humans
;
Intracranial Hemorrhages
;
Methods
;
Mortality
;
Odds Ratio
;
Pneumonia
;
Population Characteristics
;
Publication Bias
;
Stroke
3.Tuberculous Spondylitis Aggravated by Spinal Manipulative Therapy: A case report.
Sung Hun LEE ; Min Gyu CHO ; Pyeong Sik JEON
Journal of the Korean Academy of Rehabilitation Medicine 2000;24(5):1015-1018
A 43 years old woman had suffered from a lower back pain for 2 months. She experienced pain aggravation after spinal manipulative therapy that was practiced by non-licentiate. Physical examination showed tenderness on L1 and L2 spinous processes. Radionuclide bone scan with 99mTc-MDP showed increased radioactivity of L1, L2 vertebral bodies. The MRI finding showed low signal intensity of L1 and L2 vertebral bodies in T1-weighted image and high signal intensity in T2-weighted image. Needle biopsy finding showed fibrosis and inflammatory cell invasion of bone marrow. We concluded that she had tuberculous spondylitis and non-detection or negligent treatment of a preexisting disease contributed to aggravation of her symptoms. We report one case of tuberculous spondylitis aggravated by spinal manipulative therapy with review of literatures.
Adult
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Biopsy, Needle
;
Bone Marrow
;
Female
;
Fibrosis
;
Humans
;
Low Back Pain
;
Magnetic Resonance Imaging
;
Musculoskeletal Manipulations*
;
Physical Examination
;
Preexisting Condition Coverage
;
Radioactivity
;
Spondylitis*
;
Technetium Tc 99m Medronate
4.Idiopathic Chiasmal Optic Neuritis in a Pediatric Patient
Jae Pyeong JEON ; Donghun LEE ; Jong Won MOON
Journal of the Korean Ophthalmological Society 2021;62(12):1679-1684
Purpose:
We report a case of idiopathic chiasmal optic neuritis in a pediatric patient.Case summary: A 13-year-old boy with no history of systemic disease was referred to our ophthalmology clinic because of visual disturbance in both eyes of 5 days in duration. The best-corrected visual acuity was 0.08 in the right eye and finger counting at 30 cm in the left eye; mild blurring of the disc margins (both eyes) was evident on fundus examination, as were temporal hemianopsia in the right eye and diffuse field loss in the left eye. Brain magnetic resonance imaging revealed focal nodular enhancement in the optic chiasm. Blood and cerebral fluid analysis yielded no evidence of infection or autoimmune disease. Therefore, we diagnosed isolated idiopathic chiasmal optic neuritis and commenced a systemic steroid. After 5 days, the visual acuity began to improve, and the field defect was almost eliminated (except for a small central scotoma) at 1 month. He has remained stable to the time of writing (4 months after treatment) and his visual acuity has normalized.
Conclusions
Isolated idiopathic chiasmal optic neuritis developed in a pediatric patient and the visual function improved after steroid treatment. Although there was no evidence of systemic demyelinating disease, regular observation is scheduled given the possibility of late-onset disease.
5.A clinical study on aspergillus sinusitis.
Yong Woon MA ; Soon Kwan HONG ; Sea Young JEON ; Eui Gee HWANG ; Chung Seop KIM ; Jin Pyeong KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(4):727-733
No abstract available.
Aspergillus*
;
Sinusitis*
6.Meta-Analysis of Endovascular Treatment for Acute M2 Occlusion
Chul Ho KIM ; Sung Eun KIM ; Jin Pyeong JEON
Journal of Korean Neurosurgical Society 2019;62(2):193-200
OBJECTIVE: Endovascular treatment (EVT) outcomes for acute M2 segment of middle cerebral artery occlusion remains unclear because most results are obtained from patients with large artery occlusion in the anterior circulation. The objective of this study was to assess procedural outcomes for acute M2 occlusion and compare outcomes according to thrombus location (M1 vs. M2).METHODS: A systematic review was performed for online literature published from January 2004 to December 2016. Primary outcome was successful recanalization rate and symptomatic intracranial hemorrhage (S-ICH) after the procedure. A fixed effect model was used if heterogeneity was less than 50%.RESULTS: Eight articles were included. EVT showed successful recanalization rate of 69.1% (95% confidence interval [CI], 54.9–80.4%) and S-ICH rate of 6.1% (95% CI, 4.5–8.3%). The rates of good clinical outcome at 3 months and mortality were 59.4% (95% CI, 49.9–68.2%) and 14.9% (95% CI, 11.4–19.3%), respectively. According to thrombus location (M1 vs. M2), successful recanalization (odds ratio [OR], 1.539; 95% CI, 0.293–8.092; p=0.610) and S-ICH (OR, 1.313; 95% CI, 0.603–2.861; p=0.493) did not differ significantly. Good clinical outcome was more evident in M2 occlusion after EVT than that in M1 occlusion (OR, 1.639; 95% CI, 1.135–2.368; p=0.008). However, mortality did not differ significantly according to thrombus location (OR, 0.788; 95% CI, 0.486–1.276; p=0.332).CONCLUSION: EVT seems to be technically feasible for acute M2 occlusion. Direct comparative studies between EVT and medical treatment are needed further to find specific beneficiary group after EVT in patient with M2 occlusion.
Arteries
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Humans
;
Infarction
;
Infarction, Middle Cerebral Artery
;
Intracranial Hemorrhages
;
Middle Cerebral Artery
;
Mortality
;
Population Characteristics
;
Stroke
;
Thrombectomy
;
Thrombosis
7.Cerebral Blood Volume and Relative Perfusion Rate Mapping with Contrast Enhanced Gradient Echo Echo PlanarImaging.
Seung Koo LEE ; Dong Ik KIM ; Eun Kee JEONG ; Yong Min HUH ; Geum Joo HWANG ; Pyeong JEON ; Pyeong Ho YOON ; Hyun Sook KIM
Journal of the Korean Radiological Society 1998;39(2):249-255
PURPOSE: To assess regional cerebral blood volume and perfusion rate by MR imaging. MATERIALS AND METHODS:Eight normal volunteers and one patient underwent MR imaging after bolus injection of a double dose ofgadoinium(0.2mMol/kg). Gradient-echo EPI pulse sequencing was used, with TR/TE 1500/40msec, flip angle 90o, matrixsize 256X128. One hundred sequential images at the same level were obtained. The time-signal intensity curve wasplotted and converted to a time-concentration ( R2) curve. Relative cerebral blood volume was determined, withintegration of time-concentration curve pixel by pixel. Perfusion rate was determined by calculating maximal slopeof the R2 curve and the time taken to attain this. RESULTS: On volume maps, clear differentiation of gray matter,white matter and major vessels was established. The mean gray and white matter ratio of blood volume was2.78+/-0.43. Slope and volume maps were similar, but in one patient perfusion was apparently greater on the ratemap than on the volume map. CONCLUSION: Cerebral blood volvme and slope map images reflect changes in cerebralhemodynamics. It is thought that these findings can be clinically applied to the determination of vascularity inbrain tumors and acute cerebral ischemia
Blood Volume*
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Brain Ischemia
;
Healthy Volunteers
;
Humans
;
Magnetic Resonance Imaging
;
Perfusion*
8.Clinical and Imaging Findings in Spinal Cord Arteriovenous Malformations.
Sang Heum KIM ; Dong Ik KIM ; Pyeong Ho YOON ; Pyoung JEON ; Yeon Kwon IHN
Journal of the Korean Radiological Society 1997;37(6):991-998
PURPOSE: To evaluate the findings of magnetic resonance (MR) imaging and selective spinal angiography of spinal cord arteriovenous malformations (SCAVMs) and to investigate the correlation of these findings with the development of clinical symptoms. MATERIALS AND METHODS: In 16 patients diagnosed as suffering from SCAVMs, MR imaging and selective spinal angiograms were retrospectively analyzed and correlated with clinical symptoms. Clinical data were reviewed, especially concerning the mode of onset of clinical symptoms, and MR images of SCAVMs were evaluated with regard to the following parameters: spinal cord swelling with T2 hyperintensity, cord atrophy, intramedullary hemorrhage, and contrast enhancement of the spinal cord. Selective spinal angiographic findings of SCAVMs were also evaluated in terms of the following parameters: type of SCAVM, presence of aneurysms, and patterns of venous drainage. Imaging findings were also correlated with the development of clinical symptoms. RESULTS: Neurologic deficits, either acute (n=4) or insidious (n=11), were noted in 15 patients. One case without any neurologic deficit was found incidentally. MR showed spinal cord swelling (10/6), atrophy (2/16), intramedullary hemorrhage (0/16), and contrast enhancement of the cord (8/12); spinal angiograms showed the presence of associated aneurysms (6/16) and radicular venous drainage (8/16). SCAVMs. were metameric (n=4), intramedullary (n=9), or fistular (n=3). Nine of 11 patients with insidious onset showed spinal cord swelling and no radicular venous drainage with prominent perimedullary venous dilatation. Aneurysms were present in all four patients with abrupt symptoms. CONCLUSION: Systematic evaluation of the findings of MR imaging and angiography provides detailed information on the type of AVM and status of the spinal cord parenchyma, and this can be correlated with clinical manifestations of SCAVM. In patients suffering from this condition, spinal cord dysfunction due to venous congestion appears to be the main cause of clinical symptoms.
Aneurysm
;
Angiography
;
Arteriovenous Malformations*
;
Atrophy
;
Dilatation
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Drainage
;
Hemorrhage
;
Humans
;
Hyperemia
;
Magnetic Resonance Imaging
;
Neurologic Manifestations
;
Retrospective Studies
;
Spinal Cord*
9.Perirolandic Hypoperfusion on Tc-99m ECD Brain SPECT in Term Infants with Perinatal Asphyxia: Comparison with MRI and Clinical Findings.
Sun Ah LEE ; Young Hoon RYU ; Jong Doo LEE ; Yoon Joon HWANG ; Dong Ik KIM ; Pyeong Ho YOON ; Pyoung JEON ; Sung Wook MOON ; Chang Il PARK
Korean Journal of Nuclear Medicine 1997;31(1):1-8
No abstract available.
Asphyxia*
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Brain*
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Humans
;
Infant*
;
Magnetic Resonance Imaging*
;
Tomography, Emission-Computed, Single-Photon*
10.Blindness Secondary to Sphenoid Fungus Ball.
Oh Jin KWON ; Sea Yuong JEON ; Kyung Su KIM ; Jin Pyeong KIM
Journal of Rhinology 2008;15(2):148-151
The close vicinity of the optic nerve to the sphenoid sinus may cause visual loss in the sphenoid fungus ball. We present a case of blindness secondary to sphenoid fungus ball without any evidence of orbital invasion in imaging studies. A 61-year-old man, suffering from uncomplicated diabetes, was referred for right visual loss that developed 1 day ago. He perceived hand motion on the right. CT and MRI revealed a fungus ball in the right sphenoid sinus. However, there was no evidence of orbital invasion. Endoscopic sphenoethmoidectomy was performed to remove the fungus ball. Systemic mega-dose steroid and amphotericin B were started because he lost the light perception 3 days after surgery. Biopsy revealed aspergillus fungus ball and no evidence of mucosal invasion. However, blindness was not reversed. Evidence of orbital invasion in imaging diagnosis is elusive in sphenoid fungus ball; therefore, systemic antifungal treatment should be initiated and early endoscopic sphenoidotomy should be performed in case of rapidly progressing visual loss, especially in diabetic or immunocompromised patients. Mega-dose steroid therapy for optic neuropathy should be selective because it may aggravate underlying systemic diseases to cause early termination of systemic antifungal treatment.
Amphotericin B
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Aspergillus
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Biopsy
;
Blindness
;
Fungi
;
Hand
;
Humans
;
Immunocompromised Host
;
Light
;
Middle Aged
;
Optic Nerve
;
Optic Nerve Diseases
;
Orbit
;
Sphenoid Sinus
;
Stress, Psychological