1.Diagnosis and treatment of purpura.
Korean Journal of Medicine 2008;75(2):169-172
No abstract available.
Purpura
;
Purpura, Thrombocytopenic, Idiopathic
2.Clinical diagnosis and treatment of hereditary thrombocytopenia and purpura: a report of five cases and literature review.
Xin Bo LYU ; Jie YIN ; Dan Qing KONG ; Hong TIAN ; Yun LI ; Q QYU ; Jian SU ; Li Juan CAO ; Xia BAI ; Zi Qiang YU ; Zhao Yue WANG ; De Pei WU ; Chang Geng RUAN
Chinese Journal of Hematology 2023;44(1):43-47
Objective: To report the clinical manifestations and laboratory features of five patients with congenital thrombotic thrombocytopenic purpura (cTTP) and explore its standardized clinical diagnosis and treatment along with a review of literature. Methods: Clinical data of patients, such as age of onset, disease manifestation, personal history, family history, and misdiagnosed disease, were collected. Treatment outcomes, therapeutic effects of plasma infusion, and organ function evaluation were observed. The relationship among the clinical manifestations, treatment outcomes, and ADAMTS13 gene mutation of patients with cTTP was analyzed. Additionally, detection of ADAMTS13 activity and analysis of ADAMTS13 gene mutation were explored. Results: The age of onset of cTTP was either in childhood or adulthood except in one case, which was at the age of 1. The primary manifestations were obvious thrombocytopenia, anemia, and different degrees of nervous system involvement. Most of the patients were initially suspected of having immune thrombocytopenia. Acute cTTP was induced by pregnancy and infection in two and one case, respectively. ADAMTS13 gene mutation was detected in all cases, and there was an inherent relationship between the mutation site, clinical manifestations, and degree of organ injury. Therapeutic or prophylactic plasma transfusion was effective for treating cTTP. Conclusions: The clinical manifestations of cTTP vary among individuals, resulting in frequent misdiagnosis that delays treatment. ADAMTS13 activity detection in plasma and ADAMTS13 gene mutation analysis are important bases to diagnose cTTP. Prophylactic plasma transfusion is vital to prevent the onset of the disease.
Female
;
Pregnancy
;
Humans
;
Adult
;
Blood Component Transfusion
;
Plasma
;
Purpura, Thrombotic Thrombocytopenic/therapy*
;
Mutation
;
Purpura, Thrombocytopenic, Idiopathic
;
ADAMTS13 Protein/therapeutic use*
3.A Case of Thrombotic Thrombocytopenic Purpura in Childhood.
Dong Kun HYUN ; Jung Bae LEE ; Chang Hyun YANG ; Kir Young KIM
Journal of the Korean Pediatric Society 1988;31(4):511-518
No abstract available.
Purpura, Thrombotic Thrombocytopenic*
4.A case of thrombotic thrombocytopenic purpura in late pregnancy.
Aye Min SOE ; Nay Min TUN ; Elizabeth GUEVARA ; Maxim SHULIMOVICH
Blood Research 2016;51(3):207-210
No abstract available.
Pregnancy*
;
Purpura, Thrombotic Thrombocytopenic*
5.A case of thrombotic thrombocytopenic purpura achieved complete remission with plasmapheresis and prednisolone.
Ju Young KIM ; Kyoo Hyung LEE ; Kyoung Ah KIM ; Hyun Sook CHI ; Sang Hee KIM
Korean Journal of Hematology 1993;28(2):429-434
No abstract available.
Plasmapheresis*
;
Prednisolone*
;
Purpura, Thrombotic Thrombocytopenic*
6.A Clinico-Epidemilological Study of 55 Cases of Chidhood Idiopathic Thrombocytopenic Purpura.
Won Ho KANG ; Myung Hee KOOK ; Yong Sang YOO ; Jae Suk MA ; Tai Ju HWANG
Journal of the Korean Pediatric Society 1987;30(11):1207-1212
No abstract available.
Purpura, Thrombocytopenic, Idiopathic*
7.An effect of IV methylprednisolone in acute idiopathic thrombocytopenic purpura.
Jin Kuk KIM ; Kyeong Hee HONG ; Tae Gyu WHANG ; Soon Yong LEE
Journal of the Korean Pediatric Society 1991;34(9):1240-1245
No abstract available.
Methylprednisolone*
;
Purpura, Thrombocytopenic, Idiopathic*
8.Spontaneous bilateral suburothelial hemorrhage in immune thrombocytopenic purpura.
Blood Research 2015;50(1):6-6
No abstract available.
Hemorrhage*
;
Purpura, Thrombocytopenic, Idiopathic*
9.Idiopathic Thrombocytopenic Purpura.
Journal of the Korean Pediatric Society 2001;44(2):115-118
No abstract available.
Purpura, Thrombocytopenic, Idiopathic*
10.Successful treatment of steroid-refractory immune thrombocytopenia with alemtuzumab.
Chul Won JUNG ; Su Hee CHO ; Sylvia PARK ; Jun Ho JANG ; Jun Ho JI
Blood Research 2016;51(4):297-299
No abstract available.
Purpura, Thrombocytopenic, Idiopathic*