1.A Case of Thrombotic Thrombocytopenic Purpura in Childhood.
Dong Kun HYUN ; Jung Bae LEE ; Chang Hyun YANG ; Kir Young KIM
Journal of the Korean Pediatric Society 1988;31(4):511-518
No abstract available.
Purpura, Thrombotic Thrombocytopenic*
2.A case of thrombotic thrombocytopenic purpura in late pregnancy.
Aye Min SOE ; Nay Min TUN ; Elizabeth GUEVARA ; Maxim SHULIMOVICH
Blood Research 2016;51(3):207-210
No abstract available.
Pregnancy*
;
Purpura, Thrombotic Thrombocytopenic*
3.Clinical diagnosis and treatment of hereditary thrombocytopenia and purpura: a report of five cases and literature review.
Xin Bo LYU ; Jie YIN ; Dan Qing KONG ; Hong TIAN ; Yun LI ; Q QYU ; Jian SU ; Li Juan CAO ; Xia BAI ; Zi Qiang YU ; Zhao Yue WANG ; De Pei WU ; Chang Geng RUAN
Chinese Journal of Hematology 2023;44(1):43-47
Objective: To report the clinical manifestations and laboratory features of five patients with congenital thrombotic thrombocytopenic purpura (cTTP) and explore its standardized clinical diagnosis and treatment along with a review of literature. Methods: Clinical data of patients, such as age of onset, disease manifestation, personal history, family history, and misdiagnosed disease, were collected. Treatment outcomes, therapeutic effects of plasma infusion, and organ function evaluation were observed. The relationship among the clinical manifestations, treatment outcomes, and ADAMTS13 gene mutation of patients with cTTP was analyzed. Additionally, detection of ADAMTS13 activity and analysis of ADAMTS13 gene mutation were explored. Results: The age of onset of cTTP was either in childhood or adulthood except in one case, which was at the age of 1. The primary manifestations were obvious thrombocytopenia, anemia, and different degrees of nervous system involvement. Most of the patients were initially suspected of having immune thrombocytopenia. Acute cTTP was induced by pregnancy and infection in two and one case, respectively. ADAMTS13 gene mutation was detected in all cases, and there was an inherent relationship between the mutation site, clinical manifestations, and degree of organ injury. Therapeutic or prophylactic plasma transfusion was effective for treating cTTP. Conclusions: The clinical manifestations of cTTP vary among individuals, resulting in frequent misdiagnosis that delays treatment. ADAMTS13 activity detection in plasma and ADAMTS13 gene mutation analysis are important bases to diagnose cTTP. Prophylactic plasma transfusion is vital to prevent the onset of the disease.
Female
;
Pregnancy
;
Humans
;
Adult
;
Blood Component Transfusion
;
Plasma
;
Purpura, Thrombotic Thrombocytopenic/therapy*
;
Mutation
;
Purpura, Thrombocytopenic, Idiopathic
;
ADAMTS13 Protein/therapeutic use*
4.Diagnosis and treatment of purpura.
Korean Journal of Medicine 2008;75(2):169-172
No abstract available.
Purpura
;
Purpura, Thrombocytopenic, Idiopathic
5.A case of thrombotic thrombocytopenic purpura achieved complete remission with plasmapheresis and prednisolone.
Ju Young KIM ; Kyoo Hyung LEE ; Kyoung Ah KIM ; Hyun Sook CHI ; Sang Hee KIM
Korean Journal of Hematology 1993;28(2):429-434
No abstract available.
Plasmapheresis*
;
Prednisolone*
;
Purpura, Thrombotic Thrombocytopenic*
6.A Case of Idiopathic Thrombocytopenic Purpura in a Patient with Behcet's Disease.
Hyun Young SHIN ; Hyo Jung NAM ; Ju Kyoung SONG ; Seong Wook KANG ; Sang Ok LEE ; Dong Hyuk SHEEN ; Mi Kyoung LIM ; Seung Cheol SHIM
The Journal of the Korean Rheumatism Association 2005;12(2):137-142
In Behcet's disease, thrombocytopenia has rarely been reported in association with the hemolytic uremic syndrome, thrombotic thrombocytopenic purpura or in association with cyclosporine or chlorambucil in the treatment of ocular inflammatory disease and meningoencephalitis. In this paper we report a case of thrombocytopenia in a 33-year-old female with Behcet's disease who has taken no medications for three years. After history taking, physical examination, routine laboratory and bone marrow examination, we diagnosed her case as idiopathic thrombocytopenic purpura (ITP). She recovered with high dose steroid treatment. To our knowledge, this is the first report having ITP in a patient with Behcet's disease.
Adult
;
Bone Marrow Examination
;
Chlorambucil
;
Cyclosporine
;
Female
;
Hemolytic-Uremic Syndrome
;
Humans
;
Meningoencephalitis
;
Physical Examination
;
Purpura, Thrombocytopenic, Idiopathic*
;
Purpura, Thrombotic Thrombocytopenic
;
Thrombocytopenia
7.Idiopathic Thrombocytopenic Purpura in a Patient with Carcinoma of the Uterine Cervix.
Hyeong Su KIM ; Jung Han KIM ; Dong Kil NA ; Dae Young ZANG ; Min Jeong PARK ; Hong Bae KIM ; Jong Wook LEE
Korean Journal of Hematology 2009;44(1):58-61
We describe here the case a patient with advanced cervix carcinoma and who developed idiopathic thrombocytopenic purpura (ITP). A 63-year-old woman with stage IV squamous cell carcinoma of the uterine cervix and that was complicated by hydronephrosis was treated palliatively with 45Gy of external beam radiation to the pelvis. About 3 years later, she developed hematochezia and severe thrombocytopenia. The laboratory examinations showed no evidence of thrombotic thrombocytopenic purpura or disseminated intravascular coagulopathy, and she was positive for serum anti-platelet antibodies. On the bone marrow examination, there was a normal number and morphology of megakaryocytes with no evidence of malignant cell infiltration. We made the clinical diagnosis of ITP, and the intravenous immunoglobulin and steroid therapy was successful. This case suggests the possibility that ITP can occur in association with advanced cervix carcinoma.
Antibodies
;
Bone Marrow Examination
;
Carcinoma, Squamous Cell
;
Cervix Uteri
;
Female
;
Gastrointestinal Hemorrhage
;
Humans
;
Hydronephrosis
;
Immunoglobulins
;
Megakaryocytes
;
Middle Aged
;
Pelvis
;
Purpura, Thrombocytopenic, Idiopathic
;
Purpura, Thrombotic Thrombocytopenic
;
Thrombocytopenia
8.A Clinico-Epidemilological Study of 55 Cases of Chidhood Idiopathic Thrombocytopenic Purpura.
Won Ho KANG ; Myung Hee KOOK ; Yong Sang YOO ; Jae Suk MA ; Tai Ju HWANG
Journal of the Korean Pediatric Society 1987;30(11):1207-1212
No abstract available.
Purpura, Thrombocytopenic, Idiopathic*
9.An effect of IV methylprednisolone in acute idiopathic thrombocytopenic purpura.
Jin Kuk KIM ; Kyeong Hee HONG ; Tae Gyu WHANG ; Soon Yong LEE
Journal of the Korean Pediatric Society 1991;34(9):1240-1245
No abstract available.
Methylprednisolone*
;
Purpura, Thrombocytopenic, Idiopathic*
10.Spontaneous bilateral suburothelial hemorrhage in immune thrombocytopenic purpura.
Blood Research 2015;50(1):6-6
No abstract available.
Hemorrhage*
;
Purpura, Thrombocytopenic, Idiopathic*