Background: In the world there are 400 million people affected by pinworm disease and children aged 5-12 comprise of 10-90% in the epidemic center. Purpose: Main goal is to process the technology of the suppository with garlic extract. Materials and methods:130.0 gram Uliastai sort garlic with red husk (Allium sativium, Liliaceae) and 70 percent ethyl spirit 1:1. The experiment determined suppository bioavailability prepared from 3 types of base rated with cacao paraffin (80:20), cacao: paraffin (70:30), cacao from garlic extract on the turning basket equipment in the condition (pH=8) and measured it UV mini-1240 spectrometer in 240 nm. Results: From the results, we noticed that as for suppository bioavailability cacao base with 5 percent garlic extract prepared from 3 different bases, was 1.37 times more than cacao: paraffin base (70:30) and 5.23 times more than (80:20). We processed the technology scheme of suppository with 5 percent garlic extract. Suppository bioavailability cacao: paraffin (70:30), prepared from cacao base was better than cacao: paraffin base (80:20). Key words: garlic extract, suppository, bioavailability