1.A case of pulmonary veno-occlusive disease in primary pulmonary hypertension.
Hong Seog SEO ; Kyeong Ho KANG ; Hye Hyeong KIM ; Do Sun LIM ; Chang Kyu PARK ; Young Hoon KIM ; Wan Joo SHIM ; Dong Joo OH ; Jeong Euy PARK ; Young Moo RO ; Dong Kyu JIN
Korean Journal of Medicine 1993;45(3):400-406
No abstract available.
Hypertension, Pulmonary*
;
Pulmonary Veno-Occlusive Disease*
4.A case of Pulmonary Veno-occlusive Disease.
Jae Youn CHO ; Sang Youb LEE ; Sang Hwa LEE ; Jeong Kyung SUH ; Jae Jeong SHIM ; Kwang Ho IN ; Kyung Ho KANG ; Se Hwa YOO ; Kwang Taek KIM
Tuberculosis and Respiratory Diseases 1996;43(2):274-279
Pulmonary veno-occlusive disease is a rare cause of pulmonary hypertension in which the primary abnormality is obliterative obstruction of pulmonary veins, especially venules. Clinicaly, we should suspect this disease in the case of congestive cardiac failure with pulmonary hypertension, chronic interstitial pulmonary edema, and normal or elevated wedge pressure on cardiac catheterization. We experience a case of pulmonary hypertension due to pulmonary veno-occlusive disease. A 55-years -old woman developed progressive dry cough and dyspnea for 3 months. Physical examination showed normal heart sounds, diffuse crackles in the whole lung fields. The liver was not palpable and pitting edema was absent. The diagnosis was made by chest HRCT, 2-D echocardiography, normal pulmonary capillary wedge pressure on cardiac catheterization, and confirmed by thoracoscopic lung biopsy. This patient was treated with vasodilator(calcium antagonist) and with mild symptomatic improvement. We reported a case of pulmonary veno-occlusive disease with review of literatures.
Biopsy
;
Cardiac Catheterization
;
Cardiac Catheters
;
Cough
;
Diagnosis
;
Dyspnea
;
Echocardiography
;
Edema
;
Estrogens, Conjugated (USP)
;
Female
;
Heart Failure
;
Heart Sounds
;
Humans
;
Hypertension, Pulmonary
;
Liver
;
Lung
;
Physical Examination
;
Pulmonary Edema
;
Pulmonary Veins
;
Pulmonary Veno-Occlusive Disease*
;
Pulmonary Wedge Pressure
;
Respiratory Sounds
;
Thorax
;
Venules
5.Changes in the Lung after Pulmonary Hypertension Induced by Obstruction of the Pulmonary Vein in Rats.
Won Chae JANG ; In Suk JEONG ; Kyu Sung CHO ; Bong Suk OH
The Korean Journal of Thoracic and Cardiovascular Surgery 2006;39(9):659-667
BACKGROUND: Experimental studies of vascular remodeling in the pulmonary arteries have been performed actively. These models required a persistent vascular insult for intimal injury induced by chronic hypoxia, monocrotaline intoxication or chronic air embolism and characterized medial hypertrophy and neointimal formation by active synthesis of the extracellular matrix protein. The purpose of this study was to determine the pattern of pulmonary vascular remodeling after obstruction of the pulmonary vein. MATERIAL AND METHOD: Obstruction of the right pulmonary vein with a metal clip was performed in Sprague-Dawley rats (352+/-18 g, n=10) to cause pulmonary vascular disease. Fifteen days later, experimental studies were done and finally the both lungs and hearts were extirpated for experimental measurement. Pulmonary arterial pressure, weight ratio of right ventricle (RV) to left ventricle (LV) and ventricular septum (S) (RV/LV+S weight ratio), and pulmonary artery morphology (percent wall thickness, %WT) were evaluated and compared with normal control groups. RESULT: Pulmonary hypertension (38+/-12 mmHg vs 13+/-4 mmHg; p<0.05) and right ventricular hypertrophy (right ventricular/left ventricular and septal weight ratio, 0.52+/-0.07 vs 0.35+/-0.04; p<0.05) with hypertrophy of the muscular layer of the pulmonary arterial wall (percent wall thickness, 22.4+/-6.7% vs 6.7+/-3.4%; p<0.05) were developed by 15 days after obstruction of the pulmonary vein. CONCLUSION: Obstruction of the pulmonary vein developed elevation of pulmonary blood pressure and medial hypertrophy of the pulmonary artery. These results are a part of the characteristic vascular remodeling. Theses results demonstrate that obstruction of the pulmonary vein can develope not only high pulmoanry blood flow of contralateral lung but also intima injury inducing vascular remodeling.
Animals
;
Anoxia
;
Arterial Pressure
;
Blood Pressure
;
Embolism, Air
;
Extracellular Matrix
;
Heart
;
Heart Ventricles
;
Hypertension, Pulmonary*
;
Hypertrophy
;
Hypertrophy, Right Ventricular
;
Lung*
;
Monocrotaline
;
Pulmonary Artery
;
Pulmonary Veins*
;
Pulmonary Veno-Occlusive Disease
;
Rats*
;
Rats, Sprague-Dawley
;
Vascular Diseases
;
Ventricular Septum