The therapeutic methods for the treatment of primary liver cancer is in abundant supply, yet the prognosis far from satisfactory. The article mainly introduces the progress in hepatectomy, liver transplantation, ablation therapy, interventional therapy, radiotherapy, drug therapy, and biological immunity in the treatment of primary liver cancer, and it also briefs us on the multidisciplinary and comprehensive treatment of primary liver cancer, believing that comprehensive treatment is the key to improving the overall response of primary liver cancer by giving full play to the superiority of each treatment and achieving the optimal therapeutic effect.