Periampullary carcinoma metastases are usually located at
regional nodes, adjacent organs, liver or lung. On the other
hand, metastatic penile cancer is uncommon. Penile
metastasis usually originates from pelvic region with
prostate and bladder being the most frequent primary
location. We present a very rare case of periampullary
carcinoma with penile metastasis in a 49-year-old man. He
initially presented with early ampullary type periampullary
carcinoma and had pyloric preserving
pancreatoduodenectomy and adjuvant chemotherapy.
However, after six years of uneventful follow up, he
presented with a penile lesion which was confirmed to be
pancreatic metastasis. He was started on chemotherapy but
passed away two months later. Ampullary carcinoma type of
periampullary carcinoma usually presents early with
favourable prognosis. However, tumour recurrence can
present much later after definitive treatment and at a rare
site such as penis with generally poor outcome.