Objective To investigate the clinical effect of the application of autologous venous blood and rubber plaster in treating patients with necrotic ulcerative pressure sores. Methods A total of 70 patients with pressure sores were divided into the group and the control group according to random digit table with 35 cases in each group. Based on the systematic support and routine nursing, the control group was treated with rubber plaster, while the observation group received combination treatment of autologous venous blood and rubber plaster. Results In the observation group the cure rate and total effective rate were 65.7%(22/35), 94.3%(33/35) , significantly higher than those of the control group, which were 45.7%(16/35), 71.4% (25/35),the differences were significant (χ2=5.285, 7.513, P<0.05 or 0.01). The wound abscess regression time and total sore healing time was (12.8±1.6) and (12.4±2.8) months in the observation group, significantly shorter than that of the control group, which was (16.1±5.7) and (18.5±3.9) months, the differences were significant (t=3.278, 7.517, P<0.01). Conclusions Combination of autologous venous blood and rubber plaster for treatment of necrotic ulcerative pressure sores had distinct curative effect, it can accelerate surface healing process as well as improve the adherence to treatment and life quality of patients.

Objective To evaluate the clinical efficacy and safety of valsartan and methylprednisolone com-bined with cyclophosphamide for treatment of IgA nephropathy with prevailing proteinuria.Methods 118 case of IgA nephropathy patients with prevailing proteinuria were divided into the research group(60 cases)and control group (58 cases)according to random number table.Patients in the control group were given valsartan capsules(80mg/d) and methylprednisolone tablets(1mg·kg -1 ·d -1 ),patients in the research group were given cyclophosphamide tab-lets on the basis of control group(0.5 ~1.0g/m2 ,1 time /month,a total of 10 times).All the patients were treated for 12 months.The clinical efficacy,24h urine protein quantitative and plasma -albumin(ALB)were observed before and after treatment.Results After treatment,the clinical efficacy of research group and control group were 79.33% and 43.10%,the data of research group was significantly higher than that of the control group(χ2 =19.401,P <0.01), the 24h urine protein quantitative of the research group was significantly decreased from (2.0 ±1.3)g/24h before treatment to (0.9 ±0.2)g/24h in the 12 month after treatment(t =7.184,P <0.01),the ALB of the research group was significantly increased from (32.2 ±4.2)g/L before treatment to (39.5 ±4.8)g/L in the 12 month after treat-ment(t =5.335,P <0.01),the 24h urine protein quantitative of the research group afer 4,6,8,10,12 month were significantly lower than those in the control group(t =3.461,3.854,4.021,3.976,3.365,all P <0.05),the ALB of research group afer 8,10,12 month were significantly higher than those in control group(t =3.850,5.020,5.560,all P <0.05).Conclusion Valsartan combined methylprednisolone can more effectively reduce urinary protein and pro-tect renal function for the treatment of IgA nephropathy.

Due to the fast pace of modern life, sedentary lifestyle and caloric-dense, high-fat diets have caused the obesity epidemic. Obesity epidemic has not only caused serious damage to the health of consumers, but also there exists strong externalities. Therefore, the government regulation needed to reverse the problem of obesity has become the must-have measures. However, the complexity and universality of the growing problem of obesity cause the gov-ernment regulationfor the obesity epidemic fall into the dilemma of interfering the consumers' freedom of choice and improving consumer welfare. By sorting out the epidemic of obesity, this paper takes into account the long-term health risks caused by the obesity epidemic, in order to discuss the feasibility of implementing government fat tax reg-ulation, and analyze the expected effects that fat tax policy may make on food market the effect.

The paper first expounds the concept and content of patients＇ right of privacy, introduces some law regulations of patients right of privacy in our countryand dicusses the legal character and the legal responsibility about the violation of patients＇ right of privacy, administrative legal responsibility and civil legal responsibility.

Observations were made on the pathological changes of the heart muscles,livers and brains in dogs, monkeys and mice during the subacute toxic studies of 5-p-flurophenoxy primaquine citrate (MP-0090) which was compared with primaquine phosphate in same dosages.The results showed slight eosinophilic degeneration of heart muscles in some dogs and mice, focal ballon degeneration of liver cells in some dogs and fatty degeneration in one monkey.These changes were reversible and insignificant in clinic. Besides, no differences were found in pathologic changes between MP-0090 and primaquine phosphete.

Objective:As the main component of human capital, health capital's dynamic path has been generally received attention. Methods: According to Grossman’s theory of health capital, the health investment return is defined as the monetary benefits and psychological benefits and the optimum control theory is used to study the optimal path of health investment. Results:The optimum path of health investment has sole saddle point equilibrium with both stability and uniqueness. Conclusion: The maximum utility of consumers depends on the their subjective judgment of future life. As a rational consumer, it needs to consider that health risk rises with age gradually, health investment should be increased to maximize lifetime utility.

OBJECTIVE:To investigate pharmacokinetic parameters of glutathione( GSH )after intraveneous injection(iv) in dogs. METHODS: A single dose of 40 mg?kg-1 was given to 12 Beagle dogs by iv,their plasma blood sample in different times were collected and concentrations of GSH were detected by HPLC,then the pharmacokinetic parameters were calculated using 3p97 software program. RESULTS: The concentration-time curves of GSH with iv fitted to two-conpartment model. The main pharmacokinetic parameters including t1/2?、t1/2?、V(c)、CL(s)、AUC0～t were(2.32?1.26) min,(16.03?6.58) min,(1.13?0.54) L?kg-1,(0.080?0.027) L?min-1 and (546.69?189.45) ?g?h?mL-1,respectively. CONCLUSION: GSH in circulatory system of dogs after iv has short retention time and quick elimination.

0.05).CONCLUSION:The analysis shows that there is no significant difference in the efficacy and safety between olsalazine and sulphasalazine.

The maximal expiratory flow-volume (MEFV) curve were measured in 195 healthy adults. The results indicated that the values of the peak expiratory flow rate, V_(75), V_(50) and V_(25), were all higher in males than in females, and the higher the age, the lower the end expiratory flow rate. The end expiratory flow rate in chronic obstructive pulmonary disease (COPD) was decreased as the disease deteriorated. In healthy subjects, the V_(50)/V_(35) was increased with age, while in COPD patients V_(50) was decreased. The more severe the condition, the lower the rate. The authors suggest that the measurement of MEFV be used as a simple valuable method to evaluate small air way functiovs.

The factors which affect IL-2 production of human peripheral blood lymphocyte were further studied, and the methods of testing IL-2 by various mitogen activated cells such as mouse thymocyte, ConA or PHA activated mouse spleen lymphocyte or 7-10 days culture (supported by human tonsil IL-2) of human perpheral blood lymphocyte were compared. The results suggest that the amount of IL-2 produced by human blood lymphocyte is related to the concentration of lymphocyte, different batchs and concentrations of calf serum as well as purity of mitogen. The value of IL-2 tested by freshly isolated and activated cells is affected by animal variety, and the activated blast cells still response to mitogen in some extent. Among these methods, 7～ 10 days cultured human perpheral blood lymphocyte have the lowest response to mitogen and is the most sensitive way to test human IL-2t ConA activated cells is more sensitive than thymocytes in the measuring of the activity of murine and human IL-2, the interference of ConA in the IL-2 determination can be avoided by adding Methyl-D-mannopyranoside to block the activity of ConA which are present in testing cells and IL-2 samples, Testing of IL-2 activity with thymocyte is not a sensitive method, especialy for human tonsil IL-2 detectation, and needs longer time to get result.