Objective: To determine the efficacy of Guava 5% cream compared to Clotrimazole 1% cream in the treatment of Tinea corporis of patients seen at Family Medicine Department of Quezon City General Hospital Design: Randomized therapeutic clinical trial Setting: Department of Family and Community Medicine Out Patient Department of Quezon City General Hospital Study Subjects: Patients, male or female, 19 years old and above who consulted at Family and Community Medicine Department of Quezon City General Hospital Method: The study was done from August- September 2019. Fifty subjects were randomly assigned to either Group A (25) or Group B (25) using systematic sampling method. Patients in Group A were instructed to apply on affected area Clotrimazole 1% Cream twice a day for 2 weeks, while patients on Group B applied Guava 5% cream twice a day for 2 weeks. Patients were instructed follow up on Week 1 for improvement, Week 2 for evaluating outcome of treatment and Week 4 to check for recurrences Results: Total severity scores of both Groups A and B at Week 1, Week 2 and Week 4 were similar with p-values of 0.014, 0.480 and 0.386 respectively. Both groups were comparable as to the treatment outcome for Tinea corporis. Guava 5% cream is shown to be cost-effective considering the equally-effective treatment outcome and the lower average treatment cost Conclusion This study has shown that Guava 5% cream is equally effective as, and cheaper than Clotrimazole 1% cream, thus considered to be a cost-effective treatment for Tinea corporis.
Tinea ; Psidium ; Clotrimazole

Background: Medicinal plants are widely used for healthcare needs, including oral health. In the Philippines, garlic, guava, tsaang-gubat, and hierba buena, although primarily recognized as plants used for the treatment of systemic diseases, are indicated as analgesics for dental pain, treatment of gingival inflammation, and oral health maintenance. Despite studies focusing on the effectiveness of these plants for oral health, there is little to no research on the populace’s knowledge, attitude, and practices on these medicinal plants. Objectives: The study aimed to determine the knowledge, attitude, and practices of Oral Medicine patients from a dental college in Manila on four medicinal plants (garlic, guava, tsaang-gubat, and hierba buena) for oral health. Methods: A descriptive study design was used. Oral Medicine patients (694) were invited to participate in the study through daily text messages containing brief research details. The link to the three-part online questionnaire (Google Forms) was sent via text and Facebook messages, and was answerable within 15-20 minutes. Results: Two hundred fourteen (214) Oral Medicine patients participated, with 147 (68.69%) having knowledge on using medicinal plants for oral health which they mostly knew through friends and acquaintances. Most participants had a generally positive attitude toward medicinal plants for oral health and believed they were beneficial (177, 82.71%), safe, effective, and cheaper than conventional medicine (175, 81.78%), and accessible (171, 79.91%). Only 64 (29.91%) personally used medicinal plants to address their oral health conditions. Garlic (144, 97.96%) was the most widely known and used, followed by guava (52, 35.37%), hierba buena (12, 8.16%), and tsaang-gubat (4, 2.72%). Conclusion Most participants were knowledgeable with a generally positive attitude toward the four medicinal plants for oral health but did not use these to address their oral health problems.
Garlic ; Psidium ; Mentha ; Plants, Medicinal ; Oral Health

OBJECTIVETo study the chemical constituents of the leaves of Psidium guajava.

METHODThe chemical constituents were isolated by column chromatography on silica gel, Sephadex LH-20 and MPLC. Their structures were elucidated on the basis of spectral analysis.

RESULTNine compounds were isolated from this plant, and the structure of them were identified as ursolic acid (1), 2alpha-hydroxyursolic acid (2), 2alpha-hydroxyoleanolic acid (3), morin-3-O-alpha-L-arabopyranoside (4), quercetin (5), hyperin (6), myricetin-3-O-beta-D-glucoside (7), quercetin-3-O-beta-D-glucuronopyranoside (8), 1-O-galloyl-beta-D-glucose (9).

CONCLUSIONCompounds 3, 7-9 were isolated from this plant for the first time.

Plant Extracts ; chemistry ; Plant Leaves ; chemistry ; Psidium ; chemistry

The chemical constituents from the fruit of Psidium guajava were investigated. Nine triterpenoids, ursolic acid (1), 1beta, 3beta-dihydroxyurs-12-en-28-oic acid (2), 2alpha,3beta-dihydroxyurs-12-en-28-oic acid (3), 3beta,19alpha-dihydroxyurs-12en-28-oic acid (4), 19a-hydroxylurs-12-en-28-oic acid-3-O-alpha-L-arabinopyranoside (5), 3beta, 23-dihydroxy urs-12-en-28-oic acid (6), 3beta, 19alpha, 23beta-tri-hydroxylurs-12-en-28-oic acid (7), 2alpha, 3beta,19alpha, 23beta-tetrahydroxyurs-12-en-28-oic acid (8), 3alpha,19alpha,23,24-tetrahydroxyurs -12-en-28-oic acid (9) were isolated by means of chromatography, and their structures were elucidated on the basis of MS, H NMR, 13C-NMR spectra. Compounds 2, 5-9 were isolated from this plant for the first time.
Fruit ; chemistry ; Plant Extracts ; analysis ; Psidium ; chemistry ; Triterpenes ; analysis

Recently, novel Psidium meroterpenoids were reported in the guava leaves. According to careful analysis of the spectral data of literatures, the spectroscopic characteristics and biosynthetic pathway of Psidium meroterpenoids were summarized in this paper. The results showed that Psidium meroterpenoids had distinct spectroscopic features and reasonable biosynthetic routines, however the number order of carbon atoms was not consistent in the reported literatures. It was concluded that Psidium meroterpenoids were the characteristic chemical constituents of Psidium guajava Linn.
Magnetic Resonance Spectroscopy ; Plant Leaves ; chemistry ; Psidium ; chemistry ; Spectrum Analysis ; Terpenes ; chemistry

To study the chemical constituents of the 95% ethanol extract of Psidium guajava. Compounds were separated by using a combination of various chromatographic methods including silica gel, D101 macroporous resin, ODS, Sephadex LH-20 and preparative HPLC. Their structures were elucidated by physicochemical properties and spectral data Eighteen compounds were isolated and identified as (+) -globulol (1), clovane-2beta, 9alpha-diol (2), 2beta-acetoxyclovan-9alpha-ol (3), (+) -caryolane-1 ,9beta-diol (4), ent-T-muurolol (5), clov-2-ene-9alpha-ol (6), isophytol (7), tamarixetin (8), gossypetin (9), quercetin (10), kaempferol (11), guajaverin (12), avicularin (13), chrysin 6-C-glucoside (14), 3'-O-methyl-3, 4-methylenedioxyellagic acid 4'-O-beta-D-glucopyranoside (15), p-hydroxy-benzoic acid (16), guavinoside A (17) and guavinoside B (18). Compounds 2-9 and 14-16 were isolated from this plant for the first time. The ethanol extract showed 61.3% inhibition against the proliferation of colon cancer cell line SW480.
Drugs, Chinese Herbal ; chemistry ; Organic Chemicals ; analysis ; Plant Leaves ; chemistry ; Psidium ; chemistry

The present study is to study the chemical constituents from ethanol extract of Psidium guajava leaves. The constituents were separated and purified by silica gel column chromaiographios over, macroporous resin D-101, Sephadex LH-20, and ODS. Six flavonoids compounds were isolated and identified as quercetin(1), quercetin-3---D-arabinopyranoside(2), quercetin-3---D-ribopyranoside(3), quercetin-3---D-galactopyranoside(4), quercetin-3---D-glucopyranoside(5), and quercetin-3--D-xylpyranoside(6). The antioxidant effects of six flavonoids was evaluated by scavenging ability of DPPH, superoxide anion, ABTS·⁺, and reducing effect of Fe³⁺ as well as total antioxidant capacity(FRAP). Vitamin C was used as positive control. The results indicated that six flavonoids exhibited significant antioxidant effects.
Antioxidants ; chemistry ; Flavonoids ; chemistry ; Phytochemicals ; analysis ; Plant Leaves ; chemistry ; Psidium ; chemistry ; Quercetin ; chemistry

Twenty-six compounds, including sixteen meroterpenoids(1-16), a triterpenoid(17), four terpenoid derivatives(18-21), and five aromatic compounds(22-26), were isolated from the leaves of Psidium guajava. Their structures were identified by spectroscopic analyses including NMR and MS. Compounds 21-26 were obtained from plants of Psidium for the first time. Based on the structure,(R)-2-ethylhexyl 2H-1,2,3-triazole-4-carboxylate(24 a), an α-glucosidase inhibitor recently isolated from Paramignya trimera, should be revised as compound 24. Meroterpenoids 1-16 were evaluated for their antitumor and antifungal activities. Meroterpenoids psiguajadial D(4), guapsidial A(5), 4,5-diepipsidial A(7), guadial A(14), and guadial B(15) showed cytotoxicities against five human tumor cell lines(HL-60, A-549, SMMC-7721, MCF-7, and SW-480), among which 5 was the most effective with an IC_(50) of 3.21-9.94 μmol·L~(-1).
Antifungal Agents/pharmacology* ; Humans ; Magnetic Resonance Spectroscopy ; Plant Extracts ; Plant Leaves ; Psidium ; Terpenes

BACKGROUND: Seborrheic dermatitis is a common chronic, relapsing inflammatory skin condition occurring most often on the face, scalp and chest.
OBJECTIVE: To compare the efficacy and safety of 10% guava extract shampoo versus 2% ketoconazole shampoo and clobetasol 0.05% shampoo in the treatment of scalp seborrheic dermatitis.
METHODS: Forty-five patients clinically diagnosed with scalp seborrheic dermatitis were randomized to one of the three treatment groups: 10% guava extract shampoo, 2 % ketoconazole shampoo and 0.05% clobetasol shampoo. Patients were followed-up weekly for two weeks to assess the Seborrheic Area Severity Index (SASI) scores, pruritus score, patient's global assessment of improvement and adverse events.
RESULTS: After two weeks of treatment, there was no significant difference in the three groups in terms of the mean change in SASI scores (p= 0.46, ANOVA), pruritus scores and in the patient's global assessment of improvement, and frequency of adverse events.
CONCLUSION: 10% guava extract shampoo is a safe and effective alternative treatment for scalp seborrheic dermatitis.

Human ; Male ; Aged ; Middle Aged ; Adult ; Clobetasol ; Dandruff ; Dermatitis, Seborrheic ; Ketoconazole ; Pruritus ; Psidium ; Scalp ; Skin ; Treatment Outcome

OBJECTIVE: This single blind, randomized, controlled trial investigated the efficacy of the use of guava leaves as hot steam and wash for postpartum wound healing in women who underwent normal spontaneous delivery with episiotomy.
METHODS: A total of 127 women aged 18 to 45, from 37 to 41 weeks AOG, served as subjects in this study. They were allocated to three treatments arms (guava group, antibiotic group and guava + antibiotic group) through block randomization. The guava group used a solution from boiled guava leaves as hot steam and wash tid for 7 days while the antibiotic group took amoxicillin 500 mg tid also for 7 days. The 3rd arm used both treatments. Outcomes included pain score (measured using Visual Analog Scale) and wound healing (measured using REEDA Scale) at 24 hours, 3 days and 7 days postpartum.
RESULTS: Showed that mean pain scores and mean REEDA scores of the women in the three groups at 24 hours, 3 days and 7 days postpartum were not significantly different. Likewise, the risk of wound dehiscence was not significantly different for the three treatment arms. Therefore, this study revealed that guava leaves extract used as hot steam and wash is as effective as the standard oral antibiotic intake for postpartum wound care but no additional benefit is derived from combining guava leaves and oral antibiotic.
CONCLUSION: Guava leaves used as hot steam and wash may be recommended for postpartum wound care after normal spontaneous  vaginal delivery with episiotomy.

Human ; Female ; Adult ; Episiotomy ; Psidium ; Steam ; Amoxicillin ; Anti-bacterial Agents ; Pain Measurement ; Delivery, Obstetric ; Wound Healing ; Postpartum Period