Objective To analyze and study types,infections routes and causes of global pathogenic microorganisms laboratory-acquired infections cases reported in the literatures from 2000 to 2009 and to discuss prevention and control strategies.Methods ①Pathological observation of hepatic specimens:hepatic tissue pathogenic microorganisms laboratory-acquired infections.Methods PubMed,Embase,Biosis and Webs of Science covering SCIE,SSCI,CPCI-S and CPCI-SSH are chosen as data sources,“laboratory-acquired (associated) infections” are searched as the key words to search laboratory-acquired infections literature published from 2000 to 2009,from which information and data are accessed to be collected,analyzed and researched.Results There are 19 species of pathogenic microorganisms causing laboratory-acquired infections in the last 10 years,including 15 species of bacteria,accounting for 78.9％ ; 4 species of virus,accounting for 21.1％.There are 83 cases reported,of which there are 60 bacterial cases,accounting for 72.3％ ; and 23 virus cases,accounting for 27.7％.Ingestion and inhalation are main routes of infections,respectively accounting for 32.5％ and 31.3％,which are mainly due to accidents,accounting for 47.0％.Conclusion In recent years,pathogenic microbiology laboratory-acquired infections continue to occur,and it is mainly due to accidental infections,which expose laboratory workers' low sense of safety and deficient operation methods.Laboratory staff should strengthen their senses of safety and comply with safe operation procedures,which are still the key to prevent laboratory-acquired infections.