1.Which is the best peri-operative anti-coagulative therapy of transverse sinus stenting for refractory idiopathic intracranial hypertension?
Qi-Yong MEI ; Wen-Ze XIAO ; Huai-Rui CHEN ; Ru-Lin BAI ; Ke-Hua SUN ; Li-Jun HOU
Chinese Medical Journal 2012;125(16):2951-2953
Treatment of refractory idiopathic intracranial hypertension (IIH) is a challenging problem. We reported a refractory IIH patient who manifested with typical intracranial hypertensive symptoms successfully treated with endovascular stent implantation. Pre-operative cerebrospinal fluid (CSF) opening pressure is 36 cmH2O. Cerebral angiography demonstrated a stenotic lesion located at the right transverse sinus (TS). The stenotic TS returned to its normal caliber and the pressure gradient deceased from 36 mmHg to 4 mmHg after the stent placement. The intracranial hypertensive symptoms resolved and one month later, the CSF opening pressure decreased to 14 cmH2O.
Cerebral Angiography
;
Female
;
Humans
;
Middle Aged
;
Pseudotumor Cerebri
;
diagnostic imaging
;
surgery
;
Transverse Sinuses
;
diagnostic imaging
;
surgery
2.Clinical and imaging features of idiopathic intracranial hypertension.
Zhiqin WANG ; Jinxia YANG ; Xinxin LIAO ; Nina XIE ; Mengchuan LUO ; Yun TIAN ; Lingyan YAO ; Yacen HU ; Fang YI ; Yafang ZHOU ; Lin ZHOU ; Hongwei XU ; Qiying SUN
Journal of Central South University(Medical Sciences) 2021;46(11):1241-1250
OBJECTIVES:
Idiopathic intracranial hypertension (IIH) is a syndrome that excludes secondary causes such as intracranial space-occupying lesion, hydrocephalus, cerebrovascular disease, and hypoxic ischemic encephalopathy. If not be treated promptly and effectively, IIH can cause severe, permanent vision disability and intractable, disabling headache. This study aims to explore the clinical and image features for IIH, to help clinicians to understand this disease, increase the diagnose rate, and improve the outcomes of patients.
METHODS:
We retrospectively analyzed 15 cases of IIH that were admitted to Xiangya Hospital, Central South University, during January 2015 to September 2020. The diagnosis of IIH was based on the updated modified Dandy criteria. We analyzed clinical data of patients and did statistical analysis, including age, gender, height, weight, medical history, physical examination, auxiliary examination, treatment and outcome.
RESULTS:
There were 10 females and 5 males. Female patients were 22 to 42 years old with median age of 39.5. Male patients were 27 to 52 years old with the median age of 44.0. The BMI was 24.14-34.17 (28.71±2.97) kg/m
CONCLUSIONS
IIH primarily affects women of childbearing age who are overweight. The major hazard of IIH is the severe and permanent visual loss. Typical image signs have high specificity in IIH diagnosis. Prompt diagnosis and effective treatment are significantly important to improve the outcomes of patients.
Adult
;
Anemia, Iron-Deficiency
;
Female
;
Humans
;
Intracranial Hypertension
;
Male
;
Middle Aged
;
Pseudotumor Cerebri/diagnostic imaging*
;
Retrospective Studies
;
Ventriculoperitoneal Shunt
;
Young Adult
3.A clinicopathological study of demyelination pseudotumors of the brain.
Dongge LIU ; Chongqing YANG ; Xiaoxia LIU ; Kui CAI ; Di CUI ; Kaiquan MAN
Chinese Journal of Pathology 2002;31(1):16-19
OBJECTIVETo study the clinicopathological characteristics diagnosis, differential diagnosis and etiology of demyelination pseudotumors of the brain.
METHODSThe clinical features, CT, MRI scan findings, corticosteroid therapeutic effects and follow-up data of 3 cases of demyelination pseudotumors of the brain were analysed, and pathological changes were observed by histologic (HE, Luxol fast blue and Bodian) and immunohistochemical (S-P method) techniques.
RESULTSThe acute onset of demyelination pseudotumors appeared to be more predominant in our data. Clinical manifestations included headache, vomiting, a depressed conscious level, dysphasia, and paresis. CT, MRI scans showed solitary or multiple lesions in cerebral hemisphere. All the patients presented excellent response to steroid treatment. Follow-up for a period of 6 to 31 months, revealed the absence of progression or recurrence. The pathological changes were mainly located in both cerebral hemispheres, in which there were relative axonal preservation in foci loss of myelin, reactive gliosis, profuse perivascular lymphocytic infiltration and mixtures of foamy macrophages.
CONCLUSIONDemyelination pseudotumor is a distinct clinicopathologic encephalitic entity. The findings of this study suggest that the cause of tumefactive demyelination may be related to an allergic reaction triggered by viral infection.
Adolescent ; Adult ; Demyelinating Diseases ; diagnostic imaging ; metabolism ; pathology ; physiopathology ; Female ; Humans ; Immunohistochemistry ; methods ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pseudotumor Cerebri ; diagnostic imaging ; metabolism ; pathology ; physiopathology ; Tomography, X-Ray Computed ; methods