1.A Case of Isolated Protein S Deficiency, complicated by Acute Pulmonary Thromboembolism after Coronary Angiography.
Byung Hyun YOO ; Yong Joo KIM ; Won Seok PARK ; Myung Sook KIM ; Hyun Ok PARK ; Seung Won JIN ; Doo Soo CHON ; Jong Jin KIM ; Jun Cheol PARK ; Jae Hyung KIM ; Soon Jo HONG ; Kyu Bo CHOI
Korean Circulation Journal 2000;30(7):876-880
No abstract available.
Coronary Angiography*
;
Protein S Deficiency*
;
Protein S*
;
Pulmonary Embolism*
2.Two Cases of Deep Vein Thrombosis Associated with Behcet's Disease.
Hong Suk KIM ; Sung Nam CHANG ; Eun Sun CHOI ; Doyeun OH ; Wook Hwa PARK
Korean Journal of Dermatology 2000;38(1):95-98
In Behcet's disease(BD), there is a marked increase in vascular complication. Venous thrombosis is a major feature of the disease, although arterial thrombosis is rarely described. In Behcet's disease, thrombosis occurs in 20 to 30% of patients. We present two cases of Behcet's disease admitted to our hospital whose chief complaint was progressive increases in swelling and pain in their legs. In the first case, routine coagulation tests and sero-immunological tests were within normal limits, however, protein C and S activity were significantly decreased in the patient. So these findings suggest that auto-immune acquired protein S deficiency may be involved in the pathogenesis of thrombotic events in BD.
Humans
;
Leg
;
Protein C
;
Protein S Deficiency
;
Thrombosis
;
Venous Thrombosis*
3.A Case of Behcet's Disease Associated with Protein S Deficiency.
Korean Journal of Medicine 1998;55(3):427-431
Protein S is a natural anticoagulant present in the plasma that serves as a cofactor for activated protein C. The protein S level is decreased in congenital deficiency, inflammatory syndrome, DIC, hepatic disorders, malignancy, and oral anticoagulant (warfarin) therapy. Protein S deficiency provokes recurrent thromboembolism, superficial and/or deep vein thrombosis. Behcet's disease is a multisystemic disorder presenting with recurrent oral and genital ulcerations as well as ocular involvement. The mechanism of vascular involvement of Behcet's disease is not fully understood. This is a case report of Behcet's disease associated with protein S deficiency in a 44 year old male patient with deep vein thrombosis. We report the case with relevant literature review.
Adult
;
Dacarbazine
;
Humans
;
Male
;
Plasma
;
Protein C
;
Protein S Deficiency*
;
Protein S*
;
Thromboembolism
;
Ulcer
;
Venous Thrombosis
4.Recurrent Deep Vein Thrombosis due to Thrombophilia.
Afzalur RAHMAN ; AKM Monwarul ISLAM ; SAM HUSNAYEN
Korean Circulation Journal 2012;42(5):345-348
Deep vein thrombosis (DVT) is a common condition that is often under-diagnosed. Acquired or hereditary defects of coagulation or a combination of these defects may facilitate the development of DVT. Recurrent DVT, a positive family history or unusual presentation may warrant investigation for hereditary thrombophilia. Investigations are best when conducted at least one month after completion of a course of anticoagulant therapy. Most patients are managed with heparin in the acute stage overlapped by warfarin. The case presented here describes a 40-year old man undergoing three episodes of DVT. Investigations revealed protein C and protein S deficiency. Protein C, protein S and antithrombin deficiency either singly or in combination, are relatively common causes of hereditary thrombophilia. The case presented here serves as a reminder of the need to look into the underlying cause of venous thromboembolism.
Heparin
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Humans
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Protein C
;
Protein S
;
Protein S Deficiency
;
Thrombophilia
;
Venous Thromboembolism
;
Venous Thrombosis
;
Warfarin
5.A Case of Acute Renal Infarction with Protein S Deficiency.
Su Ji KIM ; Soon Oh HWANG ; Moon Su KANG ; Hyo Wook GIL ; Jong Oh YANG ; Eun Young LEE ; Sae Yong HONG
Korean Journal of Nephrology 2008;27(3):393-396
Acute renal infarction is an uncommon disease that is often misdiagnosed initially because of its nonspecific presentation. Cardiovascular disease is the major cause of thromboembolic event, but renal infarction can also occur in patient with special conditions such as hypercoagulable states. Protein S deficiency is a rare cause of the hypercoagulable states and induces both venous and arterial thrombosis. Protein S are a vitamin K dependent plasma protein that serves as a cofactor for the anticoagulant effects of activated protein C. Patients deficient in protein S is prone to recurrent thromboembolic disease. We reported a case of acute renal infarction that was associated with type II protein S deficiency in a 38-year old patient without underlying cardiovascular disease.
Cardiovascular Diseases
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Humans
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Infarction
;
Plasma
;
Protein C
;
Protein S
;
Protein S Deficiency
;
Thrombophilia
;
Thrombosis
;
Vitamin K
6.Protein S Deficiency Presenting as Severe Peripheral Arterial Insufficiency.
Yong Pil CHO ; Gil Hyun KANG ; Myoung Sik HAN ; Hyuk Jai JANG ; Yong Ho KIM ; Youn Baik CHOI
Journal of the Korean Society for Vascular Surgery 2004;20(1):142-145
Among the numerous conditions that can lead to a hypercoagulable state, protein C and S deficiencies have been frequently described. Although protein C and S deficiencies have frequently been associated with venous thromboembolic events, instances of arterial thromboses have been reported, especially in young patients. The exact incidence of protein C and S deficiencies in patients with peripheral arterial insufficiency has not been established. Given the paucity of adequate studies to define the natural history and arteriographic findings of these patients, treatment has not been well delineated. We report a young female patient who presented with severe peripheral arterial insufficiency and underwent an unusual clinical course associated with protein S deficiency.
Female
;
Humans
;
Incidence
;
Natural History
;
Protein C
;
Protein S Deficiency*
;
Protein S*
;
Thrombosis
7.Childhood Ischemic Stroke Associated with Protein S Deficiency: A case report.
Yeon Ho YOU ; Seong Soo PARK ; Jung Gyu PARK ; Jung Soo PARK ; Sung Pil CHUNG
Journal of the Korean Society of Emergency Medicine 2002;13(3):351-353
The occurrence of acute ischemic stroke in childhood is rare. The etiology of childhood ischemic stroke is different from that of an adult, and coagulation abnormalities are suspected to be related. Protein S is a vitamin-K-dependent plasma protein that inhibits the coagulation system by serving as a cofactor for activated protein C, and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. We reported the case of a child who presented with right side weakness and who was diagnosed as having a cerebral infarction associated with protein S deficiency as the cause of stroke.
Adult
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Cerebral Infarction
;
Child
;
Humans
;
Plasma
;
Protein C
;
Protein C Deficiency
;
Protein S Deficiency*
;
Protein S*
;
Stroke*
8.A Study of Protein S Deficiency in Antiphospholipid Syndrome.
Yoon Sung NAM ; Nam Keun KIM ; Myung Seo KANG ; Do Yeon OH ; Kwang Yul CHA
Korean Journal of Fertility and Sterility 2001;28(2):105-110
OBJECTIVE: To evaluate the abnormality of protein S in patients with recurrent spontaneous abortion due to antiphospholipid syndrome. MATERIALS AND METHOD: Antigen and activity of protein S were analyzed by enzyme immunoassay and clotting method, respectively. RESULTS: Of 18 patients with antiphospholipid syndrome, 4 patients were found to have no abnormality of protein S. There were 14 cases of protein S abnormality. Among them, there were 8 cases of type 1, 1 case of type 2, and 5 cases of type 3 protein S deficiency. CONCLUSION: So in the workup of patients with recurrent spontaneous abortion due to antiphospholipid syndrome, the evaluation for protein S is required.
Abortion, Spontaneous
;
Antiphospholipid Syndrome*
;
Female
;
Humans
;
Immunoenzyme Techniques
;
Pregnancy
;
Protein S Deficiency*
;
Protein S*
9.Deep Vein Thrombosis after ESWL in Patient with Protein S Deficiency.
Seong Su KIM ; Sun Bong KIM ; Hyun Chul YUN ; Yong Wan SEONG ; Eun Yong CHOI ; Duk Kyo KIM
Korean Journal of Urology 2002;43(4):339-341
ESWL is an effective treatment for renal and ureteral calculi with few serious side effects. Most complications are related to an obstruction from stone fragments lodged within the ureter with an accompanying colic and/or infection and subcapsular or perirenal hematoma. Here we report a patient with a protein S deficiency sustaining a deep vein thrombosis following an ESWL for a mid ureter stone.
Colic
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Hematoma
;
Humans
;
Protein S Deficiency*
;
Protein S*
;
Thrombosis
;
Ureter
;
Ureteral Calculi
;
Veins
;
Venous Thrombosis*
10.Deep Vein Thrombosis after ESWL in Patient with Protein S Deficiency.
Seong Su KIM ; Sun Bong KIM ; Hyun Chul YUN ; Yong Wan SEONG ; Eun Yong CHOI ; Duk Kyo KIM
Korean Journal of Urology 2002;43(4):339-341
ESWL is an effective treatment for renal and ureteral calculi with few serious side effects. Most complications are related to an obstruction from stone fragments lodged within the ureter with an accompanying colic and/or infection and subcapsular or perirenal hematoma. Here we report a patient with a protein S deficiency sustaining a deep vein thrombosis following an ESWL for a mid ureter stone.
Colic
;
Hematoma
;
Humans
;
Protein S Deficiency*
;
Protein S*
;
Thrombosis
;
Ureter
;
Ureteral Calculi
;
Veins
;
Venous Thrombosis*