1.Targeting the protein kinases for anti-cancer therapy.
Korean Journal of Hematology 2012;47(3):157-158
No abstract available.
Protein Kinases
2.Regulation of scr-family of protein tyrosine kinases.
Journal of Korean Society of Endocrinology 1993;8(2):119-124
No abstract available.
Protein-Tyrosine Kinases*
3.Research progress of necroptosis on bone related diseases.
Zu-Ge YANG ; Ruo-Xin WANG ; Hao-Zhe REN ; Feng HE ; Yuan-Jun MA ; Shi-Bin YU
China Journal of Orthopaedics and Traumatology 2021;34(7):687-690
As a new type of cell death, necroptosis is initiated by tumor necrosis factor receptor 1(TNFR1), and then activated receptor-interacting protein kinase 1(RIP1) and receptor-interacting protein kinase 3 (RIP3), following by the activation of mixed lineage kinase domain-like protein(MLKL) to deliver cell death signal. When necroptosis happens, damage associated molecular patterns (DAMPs) enter into extracellular area through the ruptured cytomembrane, followed by the disordered tissue hemeostasis. In recent years, many researches showed that necroptosis playimportant roles in a few bone related diseases, such as osteoporosis, osteonecrosis, osteosarcoma, etc. Thus, we try to briefly review the researches in this field.
Apoptosis
;
Necroptosis
;
Protein Kinases
4.Gray Hair Associated with the Multitargeted Receptor Tyrosine Kinase Inhibitor Pazopanib.
Hwan Jung YUN ; Young Joon SEO ; Hyo Jin LEE
Annals of Dermatology 2015;27(6):791-792
No abstract available.
Hair*
;
Protein-Tyrosine Kinases*
;
Tyrosine*
5.Role of 5´-AMP-Activated Protein Kinase Activators in Regulating Nuclear Factor Kappa B Signaling.
International Neurourology Journal 2016;20(3):171-171
No abstract available.
NF-kappa B*
;
Protein Kinases*
6.Role of Protein Kinase C in Normal and Preconditioned Myocardium.
Korean Circulation Journal 1999;29(6):546-549
No abstract available.
Myocardium*
;
Protein Kinase C*
;
Protein Kinases*
7.Role of protein kinases on NF- kappaB activation and cell death in bovine cerebral endothelial cells.
Young Soo AHN ; Chul Hoon KIM ; Joo Hee KIM
The Korean Journal of Physiology and Pharmacology 1999;3(1):11-18
Nuclear factor kappaB (NF- kappaB) activation is modulated by various protein kinases. Activation of NF- kappaB is known to be important in the regulation of cell viability. The present study investigated the effect of inhibitors of protein tyrosine kinase (PTK), protein kinase C (PKC) and protein kinase A (PKA) on NF- kappaB activity and the viability of bovine cerebral endothelial cells (BCECs). In serum-deprivation-induced BCEC death, low doses of TNF alpha showed a protective effect. TNF alpha induced NF- kappaB activation within 4 h in serum-deprivation. PTK inhibitors (herbimycin A and genistein) and PKC inhibitor (calphostin C) prevented NF- kappaB activation stimulated by TNF alpha. Likewise, these inhibitors prevented the protective effect of TNF alpha. In contrast to TNF alpha-stimulated NF- kappaB activity, basal NF- kappaB activity of BCECs in media containing serum was suppressed only by calphostin C, but not by herbimycin A. As well BCEC death was also induced only by calphostin C in serum-condition. H 89, a PKA inhibitor, did not affect the basal and TNF alpha-stimulated NF- kappaB activities and the protective effect of TNF alpha on cell death. These data suggest that modulation of NF- kappaB activation could be a possible mechanism for regulating cell viability by protein kinases in BCECs.
Cell Death*
;
Cell Survival
;
Cyclic AMP-Dependent Protein Kinases
;
Endothelial Cells*
;
Protein Kinase C
;
Protein Kinases*
;
Protein-Tyrosine Kinases
8.Characterization of a Point Mutation in the First Intron of Bruton's Tyrosine Kinase ( Btk ) Gene.
Eun Kyeong JO ; Chang Hwa SONG ; Young Ja SONG ; Dul Lei MIN ; Hwa Jung KIM ; Kyu LIM ; Min Ho SHONG ; Jae Ho LEE ; Jung Soo KIM ; Jeong Kyu PARK
Korean Journal of Immunology 2000;22(4):197-205
No abstract available.
Introns*
;
Point Mutation*
;
Protein-Tyrosine Kinases*
;
Tyrosine*
9.Involvement of Mitogen-Activated Protein Kinase in Aspirin-induced Expression of Cyclooxygenase-2 in Amnionic Cell Line WISH Cells.
Goo Hwa JE ; Moon Suk CHA ; Jong Young GWAK
Korean Journal of Obstetrics and Gynecology 2000;43(12):2191-2197
No abstract available.
Amnion*
;
Cell Line*
;
Cyclooxygenase 2*
;
Protein Kinases*
Result Analysis
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