No abstract available.
Diagnosis* ; Prostatic Neoplasms*

PSA is a protein with antigen properties, generated by epicyte of prostate gland, excretes into microtube and then comes mostly into sperma, litter into serum and lymphatic fluid with unclear mechanism. PSA in these are determined by chemicoimmune. The average human serum PSA is 2.5 ng/ml. PSA is specific antigen with cells of prostate-gland and the application of PSA test in diagnostics and monitoring is significant in clinical. Especially, the level of PSA help to early diagnose the prostatic cancer and distinguished diagnose between prostatomegaly and prostatic cancer.
Prostatic Neoplasms ; Antigens ; diagnosis

No abstract available.
Diagnosis* ; Prostate* ; Prostatic Neoplasms* ; Ultrasonography*

Primary neoplasms arising in vesical diverticula are rare and present special problems in diagnosis and treatment. We report a case of primary carcinoma arising in vesical diverticula with associated benign prostatic hypertrophy.
Diagnosis ; Diverticulum* ; Prostatic Hyperplasia ; Urinary Bladder Neoplasms

More and more clinical evidence has confirmed the limitations of the use of serum PSA in the screening, detection and treatment of prostate cancer, and scientists are continuously seeking for new biomarkers of the disease. The discovery of early prostate cancer antigen 2 (EPCA-2) has provided a new base for the screening, detection, treatment and follow-up of prostate cancer.
Antigens, Neoplasm ; analysis ; Early Diagnosis ; Humans ; Male ; Prostatic Neoplasms ; diagnosis

Aged ; Carcinoma ; diagnosis ; Diagnosis, Differential ; Humans ; Male ; Prostatic Neoplasms ; diagnosis ; Rectal Neoplasms ; diagnosis

To define the practical value of prostatic needle biopsy in patients with suspicious prostatic carcinoma we studied the analysis of the clinical records of 49 patients underwent the prostatic needle biopsy at Severance Hospital during the 5 year period from 1976 through 1980. Forty-nine patients had been biopsied; carcinoma was found in 3 of 15 patients (20 per cent) not having prostatic induration, 6 of 17 (35 per cent) with minimal or equivocal induration and 12 of 17 (71 per cent) with marked induration. The results suggest that the vast majority of the patients with prostatic carcinoma has some degree of palpable induration and that a high index of suspicion appears warranted and needle biopsyshould be performed when any prostatic induration is present on digital rectal examination.
Biopsy, Needle* ; Diagnosis* ; Digital Rectal Examination ; Humans ; Needles* ; Prostatic Neoplasms

PURPOSE: To summarize current urologic measures in the diagnosis of prostate cancer. MATERIALS AND METHODS: Current urologic literatures were evaluated. RESULTS: Prostate-specific antigen(PSA) is now a routine part of the investigation of men with suspected prostate cancer. While a very useful test, it still has its problems, in particular its lack of specificity. Since PSA may overlap in men with and without prostate cancer, other derivatives of PSA were developed to enhance the ability for detecting early stage prostate cancer. To date, for the initial biopsy, the optimal number of biopsy core for detecting prostate cancer remains controversial. Furthermore, it is also unclear who should undergo a repeat biopsy and when to stop biopsying. CONCLUSIONS: This review describes the current problems with PSA testing in prostate cancer diagnosis and highlights potential ways in which these may be reduced. In addition, although there is no universally accepted technique of prostate biopsy, the current literature supports use of more extensive biopsy techniques to increase the likelihood of prostate cancer detection.
Biopsy ; Diagnosis* ; Humans ; Male ; Prostate* ; Prostatic Neoplasms* ; Sensitivity and Specificity

For lack of the biomarker, early diagnosis of prostate cancer is often difficult. Caveolin-1 (Cav-1) is an important oncogene and a major structural coat protein of caveolae, which is involved in multiple cellular functions including molecular transport, cell adhesion, and signal transduction, as well as in the development and progression of prostate cancer. Cav-1 is secreted as a biologically active molecule that promotes cell survival and angiogenesis within the tumor microenvironment, and is overexpressed in the metastatic and primary sites of human prostate cancer. Secreted Cav-1 can be detected in the peripheral blood, and its expression level has an indicative value in the diagnosis and prognosis of prostate cancer. This review focuses on the structure and biological characteristics of Cav-1 and its correlation with prostate cancer.
Biomarkers, Tumor ; Caveolin 1 ; Humans ; Male ; Prostatic Neoplasms ; diagnosis

PSA-based screening has always been one of the controversial topics among urological researchers. In spite of its benefit in detecting early prostate cancer, PSA-based screening may not only result in widespread overdiagnosis and overtreatment of an often indolent disease, which is life-threatening in only a minority of patients, but also subject participators to such complications as erectile dysfunction and incontinence. Besides, whether PSA-based screening can reduce prostate cancer specific mortality has received considerable attention. This review offers a comparative analysis of recent studies on PSA-based screening for prostate cancer.
Humans ; Male ; Prostate-Specific Antigen ; blood ; Prostatic Neoplasms ; blood ; diagnosis