Acute Disease ; Administration, Intravaginal ; Alprostadil ; adverse effects ; analogs & derivatives ; therapeutic use ; Drug-Related Side Effects and Adverse Reactions ; Female ; Humans ; Middle Aged ; Myocardial Infarction ; chemically induced ; drug therapy ; Nitroglycerin ; therapeutic use ; Pessaries ; Prostaglandins E, Synthetic ; adverse effects ; therapeutic use

No abstract available.
Misoprostol*

A randomised controlled clinical trial was performed on 180 pregnant women with indications for labour induction who were divided into 2 groups. Groups 1: each pregnant woman received 50 μg intravaginal misoprostol every 4h (total 250 μg). Group 2: intravenous oxyticin to induce the labour. The successful rate of misoprotol group was 89,89%, higher than oxytocin group- 70%. The interval from induction to vaginal delivery was longer in misoprostol group (8,47± 2,85h verus 6,45± 2,64h)
Labor, Induced ; misoprostol ; Oxytocin ;

Labour induced effect of misoprostol in comparing with oxytoxin on the ending 3rd trimestre of pregnancy was studied in 180 subjects at the Central Hospital of Gynecology and Obstetrics from January 1997 to January 2003. In 89.89% of misoprostol applicants and 67.78% of oxytoxine applicant success were reached. Labour induced meantime of misoprostol applicants 6.25  2.07 hours, oxitoxine 4.31  2.29 hours. Vaginal tract delivery in 88.3% of misoprostol applicant group and 70% of oxytoxine. Caesarian section 27.78% in misoprostol group, lower than oxytoxine group 44.44%.
Misoprostol ; Oxytocin ; Pharmaceutical Preparations

From Dec. 2003 to Feb 2004, 90 women of 6-12 week pregnancy received 100 μg intra vaginal misoprostol 3 hours before intervention at central Hospital of Ggn. and Obst. 96,67% had got success, with the mean cervical dilatation of 8,1± 0,92mm. Side effect manifested in 2,2% of patients
Misoprostol ; pregnancy ; Labor Stage, First

90 cases of pregnancy termination by vaccum at the 6th –12th week of gestation, using misoprostol vaginal insertion with cervix prepared 3 hours before this operation were performed at the Central Hospital of Gynecology and Obstetrics from December 2003 to February 2004. The subjects had received intravaginal 400mg Misoprostol 3h befor the vacuum aspiration of the fetus. Results showed the success rate of 96.67%, the mean dilatation of cervix reached 8.1  0.92mm.
Pregnancy Trimester, First ; Misoprostol ; Pregnancy

The study was carried out at Hung Vuong Hospital in 1998 to compare vaginal misoprostol with extra-amniotic balloon to induce abortion in second trimester. Patients were received either 800mcg misoprostol vaginally (n=87) or 500ml of 0.9% NaCl solution inserted into extra-amniotic cavity (n= 93) for induced abortion. Vaginal misoprostol was repeated 24-hourly for maximum of three times. The abortion rates were 98.9% and 96.8% for misoprostol and balloon group, respectively. A second attempt was need in approximate one third of patients in misoprostol group and 10% in balloon group. Side effects of misoprostol were mild and transient. Vaginal misoprostol is as effective as balloon for induced abortion in second trimester. Misoprostol is cheap and easily stored and used. Vaginal misoprostol could be considered as an alternative to balloon for induced abortion
Abortion, Therapeutic ; Misoprostol ; Abortion, Induced

A retrospective study of 200 Kovacs has been applied in 2nd trimester abortion in 1997 and other 200 by MSP in 1998. -MSP could be efficacy in 2nd trimester abortion as Kovacs.-In first 48h, the natural abortion by MSP and Kovacs is the same.-The propotion of MSP abortion is higher than Kovacs, hospitalized stay length of MSP is shorter than Kovacs.-No infection in MSP trials
Misoprostol ; Pregnancy Trimester, Second ; Pregnancy ; Abortion, Induced

OBJECTIVE: To evaluate the effectiveness of single preoperative dose of misoprostol to reduce intraoperative hemorrhage during laparoscopic myomectomy. METHODS: We reviewed retrospectively the medical records of 148 patients who underwent laparoscopic myomectomy in Gangnam CHA Medical Center between January 2007 and December 2009 by single surgeon. Among them, 46 patients used preoperative transrectal misoprostol. One hundred two patients underwent laparoscopic myomectomy in conventional method without any preoperative agents. RESULTS: The two groups were similar in baseline characteristics. There was no significant difference in mean blood loss (misoprostol group: 203.3+/-181.8 mL vs. no agent group: 207.7+/-144.5 mL), operation time (misoprostol group: 113.3+/-28.2 min vs. no agent group: 113.4+/-31.5 min), and hemoglobin change (misoprostol group: 2.0+/-1.0 g/dL vs. no agent group: 1.9+/-1.0 g/dL). Two patients needed transfusion in misoprostol group whereas none in control group, but there was no statistical significance. CONCLUSION: A single preoperative dose of transrectal misoprostol cannot reduce bleeding during laparoscopic myomectomy.
Hemoglobins ; Hemorrhage ; Humans ; Medical Records ; Misoprostol ; Retrospective Studies

OBJECTIVE: The aim of this study was to accumulate the knowledge about medical abortion by assessment of the efficacy of medical abortion using methotrexate and misoprostol versus misoprostol in early pregnancy. METHODS: The 35 women at less than 56 days' gestation underwent medical abortion were reviewed prospectively. Seventeen women (group 1) underwent medical abortion using methotrexate with misoprostol and eighteen women (group 2) underwent using misoprostol alone. We measured percent change of serum beta-hCG, successful abortion, duration of vaginal bleeding, side effects. RESULTS: Overall success rate was 91.4%: success rate in group 1 was 100%, 84.2% in group 2. Vaginal bleeding lasted for a mean of 12 days (group 1), and 10 days (group 2). Percent change of serum beta-hCG level from day 1 to day 4 was 93.1 (group1), and -68.0 (group 2), that from day 1 to day 7 was -90.6 (group 1), and -97.6 (group 2). Side effects were minimal. CONCLUSION: No significant difference between group 1 (methotrexate and misoprostol) and group 2 (misoprostol alone) was found. Medical abortion is considered to be the therapy that is safe, and effective procedure in early pregnancy.
Female ; Humans ; Methotrexate* ; Misoprostol* ; Pregnancy* ; Prospective Studies ; Uterine Hemorrhage