1.A Case of Cyclopia Delivered from a Diabetic Mother.
Yuk Jea CHANG ; Kyung Sim KOH ; Won Ki LEE ; Choong Hak PARK
Korean Journal of Obstetrics and Gynecology 1997;40(3):645-651
Cyclopia is a rare congenital fetal anomaly, characterized by a single median eye and a grotesquily shaped nose(proboscis) that arises from the supraorbital area. It is consistently associated with serere holoprosencephaly, which is the failure of cleavage of the prosencephalon with a deficite in the midiline facial development. Holoprosencepphaly occurs in as many as 1 to 2 % of diabetic mothers. A case of cyclopia delivered from a diabetic mother is presented with a brief review of literatures.
Holoprosencephaly
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Humans
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Mothers*
;
Prosencephalon
2.A Case of Cyclopia Associated with Trisomy 13.
Ji Hae SEOK ; Seong Wook CHUNG ; Seong Kweon SON ; Ri Ra LEE ; Deok Hi LEE ; In Koo KANG ; Ik Soo KIM
Korean Journal of Obstetrics and Gynecology 1999;42(8):1839-1843
Cyclopia is rare congenital craniofacial anomaly, in which the eyes are fused together and located in a single orbit. It is consistently associated with severe holoprosencephaly, which is the failure of cleavage of the prosencephalon with a deficit in the midline facial development. chromosomal study revealed 47, X( ), +13 (Patau syndrome).
Holoprosencephaly
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Orbit
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Prosencephalon
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Trisomy*
3.The change of brain temperature during forebrain ischemia in rat.
Yoon Seob NA ; Jae Young KWON ; Hae Kyu KIM ; Soung Wan BAIK ; Inn Se KIM ; Kyoo Sub CHUNG
The Korean Journal of Critical Care Medicine 1992;7(1):35-40
No abstract available.
Animals
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Brain*
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Ischemia*
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Prosencephalon*
;
Rats*
4.A Case of Holoprosencephaly.
Hee Eun KO ; Il Han LEE ; Ji Hoon KIM ; Ey Sup SHIM ; Jae Whoan KOH ; Yong Bong KIM
Korean Journal of Obstetrics and Gynecology 2002;45(11):2035-2038
Holoprosencephaly is a rare developmental defect due to incomplete cleavages of the prosencephalon during the third week of fetal development. It was associated with chromosomal anomalies, genetic syndrome, teratogen, or genetic disorder of non-syndromic HPE. Early antenatal detection of holoprosencephaly was done by high resolution ultrasonography. According to its severity and prognosis, it was capable of proper treatment of holoprosencephaly. We report one case of holoprosencephaly with a brief review of the literature
Fetal Development
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Holoprosencephaly*
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Prognosis
;
Prosencephalon
;
Ultrasonography
5.Dynorphin and enkephalin mRNAs in the rat forebrain by in situ hynridization histochmistry.
Korean Journal of Anatomy 1992;25(2):179-187
No abstract available.
Animals
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Dynorphins*
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Enkephalins*
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Prosencephalon*
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Rats*
;
RNA, Messenger*
6.Reduction of Brain Infarct Size and Extracellular Glutamate Accumulation by Dihydrokinate in Spontaneously Hypertensive Rat after Transient Forebrain Ischemia.
Yong Hua ZHANG ; Zheng Hua CAI ; Yang CHEN ; Yong Cai LI
Journal of Korean Neurosurgical Society 2004;36(4):310-316
No abstract available.
Brain*
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Glutamic Acid*
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Intracranial Aneurysm
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Ischemia*
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Prosencephalon*
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Rats, Inbred SHR*
7.Two Cases of Holoprosencephaly.
Ill Hyoun CHAE ; Myoung Chan KIM ; Se Won SHIN ; Seong Lim LEE ; In Sun KIM ; In Bae KIM ; Bong Choon JO ; In Cheol CHOI ; Jong Gak PARK
Korean Journal of Obstetrics and Gynecology 1999;42(8):1869-1876
Holoprosencephaly is a rare malformation complex or development defect including different degrees of incomplete cleavages of the embryonic prosencephalon and varying degrees of the midface defects, resulting from the defect of prechordal mesoderm, migrating forward into the area anterior to the notochord during the third week of fetal development. Early antenatal diagnosis of holoprosencephaly is important to find out its severity, to predict its prognosis, and to determine proper management according to its prognosis and severity. The possibility of early antenatal diagnosis of holoprosencephaly by ultrasound has been suggested, but occasionally missed and rarely confirmed. We present one case of lobar holoprosencephaly, diagnosed postnatally and one case of alobar holoprosencephaly, diagnosed antenatally in our hospitals.
Fetal Development
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Holoprosencephaly*
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Mesoderm
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Notochord
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Prenatal Diagnosis
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Prognosis
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Prosencephalon
;
Ultrasonography
8.A Case of Holoprosencephaly.
Mi Hee KIM ; Su Chin YANG ; Eun Na CHO ; So Yang PARK ; Hyun Sook AN ; Won Young CHOI
Korean Journal of Obstetrics and Gynecology 2002;45(9):1636-1640
Holoprosencephaly is a complex abnormality of the forebrain that is postulated to derive from a failure in the diverticulation of the embryonic prosencephalon. Early antenatal diagnosis of holoprosencephaly is important to find out its severity, to predict its prognosis and to determine proper treatment according to its prognosis and severity. With recent development of high resolution ultrasonography, it is possible to detect a fetus with holoprosencephaly at early antenatal period. We report a case of alobar holoprosencephaly, diagnosed antenatally with its sonographic and autopsy finding.
Autopsy
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Fetus
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Holoprosencephaly*
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Prenatal Diagnosis
;
Prognosis
;
Prosencephalon
;
Ultrasonography
9.Three Cases of Holoprosencephaly.
Korean Journal of Perinatology 1999;10(4):518-523
Holoprosencephaly is a rare complex cerebral anomaly produced by a failure of cleavage of the prosencephalon. The association of brain anomalies and facial dysmorphism is a typical finding. There are three types(alobar, semilobar, and lobar) of holoprosencephaly. Among these the alobar type has the worst prognosis. The early antenatal diagnosis of the holoprosencephaly is very important determinant for initiating the therapeutic abortion. We report 3 cases of alobar holoprosencephaly with the brief review of the literature.
Abortion, Therapeutic
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Brain
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Female
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Holoprosencephaly*
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Pregnancy
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Prenatal Diagnosis
;
Prognosis
;
Prosencephalon
10.A Case of Alobar Holoprosencephaly with Cyclopia and Proboscis in Prematurity.
Seok Woo PARK ; Yun Hee KIM ; Tae Jeoung SUNG ; Young Se KWON ; Yong Hoon JUN ; Lucia KIM
Journal of the Korean Society of Neonatology 2004;11(2):247-251
Holoprosencephaly is a developmental malformation complex of forebrain and midface which arises from incomplete cleavage of the embryonic forebrain. It is subdivided into alobar, semilobar and lobar types based on the degree of growth disturbance within the anterior wall of the telencephalon, particularly in the midline. Cyclopia is the most severe form of alobar holoprosencephaly presenting a single median eye and a blind-ending proboscis usually located above the eye. We report a case of alobar holoprosencephaly with cyclopia and proboscis in premature infant.
Holoprosencephaly*
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Humans
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Infant, Newborn
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Infant, Premature
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Prosencephalon
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Telencephalon