No abstract available.
Biomarkers* ; Magnesium* ; Propionibacterium acnes* ; Propionibacterium*

No abstract available.
Biomarkers* ; Propionibacterium acnes* ; Propionibacterium* ; Vitamin D* ; Vitamins*

No abstract available.
Biomarkers* ; Propionibacterium acnes* ; Propionibacterium* ; Vitamin D* ; Vitamins*

No abstract available.
Acne Vulgaris* ; Cytosol* ; Humans ; Propionibacterium acnes* ; Propionibacterium*

BACKGROUND: Phototherapy has been studied as an alternative option for the treatment of acne. Propionibacterium (P.) acnes produces endogenous porphyrins as a by-product of metabolism. Light of particular wavelengths activates the porphyrins and induces a photodynamic reaction which subsequently kills the P. acnes. OBJECTIVE: The purpose of this study was to evaluate and analyze the photoinactivation efficacy of different wavelengths against P. acnes in vitro. METHODS: Using an LED lamps to emit light of variable wavelengths (370 nm, 385 nm, 395 nm, 405 nm, 470 nm, 505 nm, 590 nm, 630 nm and 880 nm), we examined the change of P. acnes colonies on agar plates after irradiation for 1, 3, 6 and 12 hours. Further investigations were also performed by irradiation on liquid medium, once, twice or three times consecutively, with an interval of 24 hours. RESULTS: Light irradiation of wavelengths 385 nm, 395 nm, 405 nm and 470 nm, was found to decrease the number of P. acnes colonies on agar plates by about 50%. In liquid medium, we observed the photoinactivation effect of light irradiation on P. acnes with the wavelengths 370 nm, 385 nm, 395 nm, 405 nm and 470 nm. However, we observed no photoinactivation effect on P. acnes with the wavelengths 505 nm, 590 nm, 630 nm or 880 nm. CONCLUSION: By in vitro testing, we have demonstrated that light irradiation of wavelengths up to a maximum of 470 nm are effective in decreasing P. acnes and therefore may be a good alternative treatment modality for acne.
Acne Vulgaris ; Agar ; Metabolism ; Phototherapy ; Porphyrins ; Propionibacterium acnes* ; Propionibacterium*

BACKGROUND: Nadifloxacin is a synthetic fluoroquinolone with a broad spectrum. It has been suggested to not only have antibacterial, but also anti-inflammatory actions. In addition, it is effective against antibiotic-resistant Propionibacterium acne. Upon review of the literature, however, no studies have been performed concerning the efficacy and safety in terms of irritation potential and skin barrier changes after applying nadifloxacin. OBJECTIVE: This study intended to evaluate the skin irritation and changes of the skin barrier function associated with the administration of nadifloxacin 1% cream for the treatment of acne vulgaris. Furthermore, the efficacy and safety of nadifloxacin 1% cream were also assessed. METHODS: The changes in the lesion counts, Korean Acne Grading System (KAGS) and adverse events were recorded. The biophysical profiles of the skin, including transepidermal water loss (TEWL), skin surface hydration and redness were measured by Tewameter(R), Corneometer(R) and Mexameter(R) for 3 weeks. RESULTS: At the end of the therapy, 69% of inflammatory lesions (p<0.0001) and 27% of noninflammatory lesions (p=0.26) resulting from acne were decreased from the baseline. Adverse events were reported in two patients, but they were transient and tolerable. The skin barrier function showed no changes during the treatment periods. CONCLUSION: Nadifloxacin 1% cream is effective for the treatment of acne vulgaris without the changes of skin barrier function.
Acne Vulgaris ; Fluoroquinolones ; Humans ; Propionibacterium ; Quinolizines ; Skin

We report the cases of 3 young individuals, each of whom presented to our hospital for the evaluation and treatment of sudden onset chondrolysis. Previously, all 3 individuals had undergone arthroscopic knee procedures over a similar time at another hospital. In this paper, we review the possible problems that cause chondrolysis during or after arthroscopic procedures, such as the followings: use of thermal treatment, occult infection with Propionibacterium acnes, idiopathic or iatrogenic osteochondral injury, high temperature of fluid during arthroscopic irrigation, improperly placed implants, and the use of an intra-articular pain pump. We can exclude other causes of chondrolysis through the clinical course of the patients and surgical records and progress records. We conclude that the possible cause of chondrolysis in all cases was due to thermal injury caused by high temperatures, which decreased or blocked the irrigation fluid flow generated during arthroscopy.
Arthroscopy ; Humans ; Knee ; Knee Joint ; Propionibacterium acnes

BACKGROUND: Acne is principally a disorder of adolescence. However, a number of observational studies have documented a significant degree of acne in adult women. One study found a difference in women between late-onset acne and acne that persisted from adolescence. There were significant higher sebum excretion rates among women whose acne originated during the teenage years compared with late-onset acne groups. OBJECTIVE: The purpose of this study was to examine the clinical features of patients with acne and to compare the sebum excretion rates and the density of P acnes in adult acne with that in adolescent acne. METHODS: Thirty nine patients with acne vulgaris were clinically evaluated. Sebum secretion rates were evaluated by Sebutape method. The density of P acnes counted by scrub method. RESULTS: 1. The severity grades were mild to moderate in adult acne groups, consisting with the lower acne lesion counts than that of adolescent acne groups. 2. Sebum secretion rates by Sebutape(R) method showed different patterns in two groups. The mean value in the adult acne groups was lower than that in adolescent acne groups, but not statistically significant. Chin area dominant pattern, shown in adult acne groups, were not apparent in adolescent acne groups. 3. The density of P acnes was a lower mean value in the adult acne groups, but not statistically significant. Only in adolescent acne groups, the severity grades are well correlated to the density of P acnes. CONCLUSION: Adult acne was mild to moderate in severity. Clinically, adult acne differs from adolescent acne in that the lesions are located most commonly around the chin. Sebum excretion rate was the highest in the chin area of patients with adult acne. But there was no significant difference in two groups. Also the density of P acnes was not significantly different in two groups.
Acne Vulgaris* ; Adolescent* ; Adult* ; Chin ; Female ; Humans ; Propionibacterium acnes* ; Propionibacterium* ; Sebum*

Chronic endophthalmitis following cataract extraction and intraocluar lens implantation has been reported occasionally and Propionibacterium acnes is Known as the most common organism. This infection is often misdiagnosed as uveitis in early stage, and diagnosis depends on anaerobic culture of intraocular specimens. Intravitreal infection of antibiotics, pars plana vitredtomy, removal of IOL with lens capsule are suggested for successful treatment of chronic endophthalmitis. We report a case of Propionibacterium acnes endophthalmitis after extracapsular cataract extraction and posterior chamber lens(PCL) implantation that was treated successfully by PCL removal and intraviteal antibiotic infection.
Anti-Bacterial Agents ; Cataract Extraction* ; Cataract* ; Diagnosis ; Endophthalmitis* ; Propionibacterium acnes* ; Propionibacterium* ; Uveitis

BACKGROUND: Acne vulgaris is one of the most prevalent and emotionally debilitating dermatologic diseases. Emerging problems with conventional acne treatments, such as the resistance of Propionibacterium acnes to antibiotics and the safety of oral isotretinoin, create a demand for other treatment modalities for acne. An evolving understanding of the Propionibacterium acnes-produced porphyrins and the development of a number of light sources have led to the application of photodynamic therapy for the treatment of acne. OBJECTIVE: To study the effect of light therapy on the treatment of Acne Vulgaris using acne mode intense pulsed light (IPL), and photodynamic therapy with a combination of topical 5-Aminolevulinic acid (ALA, 20%) and acne mode IPL. A comparison of the two treatment modalities would then be made to examine the effect on inflammatory acne lesions and sebum excretion. METHODS: Thirteen patients with varying degrees of acne were included in the study after a 4 week washout period. ALA (20%) was applied to half of the face on each patient. After one hour, the whole face was exposed to intense pulsed light (DECA(R), Italia) using an acne mode (400~1,200 nm) starting at a fluence of 11 J/cm(2). The procedure was carried out three times with 2 week intervals, and the patients were evaluated on post-op 2nd, 4th, and 6th weeks. Histologic changes were observed before and after treatment. RESULTS: After the first and second treatment, there was a statistically significant reduction in inflammatory acne lesion counts and the amount of sebum production from baseline, in both the ALA-PDT group and the IPL group (p<0.05). However, no statistically significant reduction was shown after the third treatment in both groups. There was a slightly higher reduction in the count of inflammatory lesions and the amount of sebum production in the ALA-PDT site compared to the IPL site, but it was not statistically significant. On histologic examination, dermal inflammatory cell infiltrations around the perivascular and periappendageal area were significantly reduced and sebaceous glands became smaller after the 3rd treatment. The adverse effects were negligible. CONCLUSION: ALA-PDT using acne mode IPL, and light therapy using acne mode IPL alone were effective in the reduction of inflamed lesions and sebum secretion in patients with mild to moderate acne vulgaris. Furthermore, no significant adverse effects were observed with both treatments. However, no remarkable contrast of therapeutic effect was statistically observed between the two therapies either.
Acne Vulgaris* ; Anti-Bacterial Agents ; Humans ; Isotretinoin ; Photochemotherapy* ; Phototherapy* ; Porphyrins ; Propionibacterium ; Propionibacterium acnes ; Sebaceous Glands ; Sebum