The purpose of this study was to review occupational reproductive abnormalities and occupational bladder cancer in Korea and to discuss their toxicological implications. Reproductive dysfunction as a result of 2-bromopropane poisoning was first reported in Korean workers. In 1995, 23 of the 33 workers (25 female and 8 male workers) who were exposed to 2-bromopropane during the assembly of tactile switch parts developed reproductive and/or hematopoietic disorders. A total of 17 (68%) workers were diagnosed with ovarian failure. Two of the eight male workers experienced azoospermia and four workers experienced some degree of oligospermia or reduced sperm motility. In summary, 2-bromopropane poisoning caused severe reproductive effects in Korean workers. The prognosis was poor for reproductive dysfunction. A few cases of occupational bladder cancer have been reported in Korea, whereas other cancers of the urinary tract have not been reported after occupational exposure. A few cases of benzidine-induced cancer have been reported in Korea and 592 workers in Japan have received compensation for benzidine and beta-naphthylamine-induced cancer. In conclusion, a few cases of benzidine-induced occupational bladder cancer have been reported in Korea. However, benzidine-induced bladder cancer will likely be an important occupational health issue in Korea in the coming years.
2-Naphthylamine/toxicity ; Azoospermia/chemically induced/epidemiology ; Benzidines/toxicity ; Female ; Humans ; Hydrocarbons, Brominated/toxicity ; Infertility/*chemically induced/*epidemiology ; Male ; Occupational Diseases/*chemically induced/*epidemiology ; Occupational Exposure/adverse effects ; Oligospermia/chemically induced/epidemiology ; Primary Ovarian Insufficiency/chemically induced/epidemiology ; Republic of Korea ; Sperm Motility/drug effects ; Urinary Bladder Neoplasms/*chemically induced/*epidemiology