In this study, the career and official ranks of the authors of the Sejong text(1443-1445), Sejo text(1451-1464), and Seongjong text(1475-1477) of {Classified Collection of Medical Prescriptions} were investigated. In the completion of Sejong text, Kim Rye-mong(1406-1469), Ryu Seong-won(?-1456), and Min Bo-hua(?) collected and arranged all medical books inside and outside of Choseon; Kim Moon(?-1448), Shin Seok-jo(1407-1459), Lee Ye(1419-1480), Kim Soo-on(1410-1481), Jeon Soon-eui(?), Choi Yun(?), and Kim Yu-ji(?-1469) took part in the edition; Lee Yong(1418-1453), Lee Sa-cheol(1405-1456), Lee Sa-soon(?-1455), and Rho Joong-rye(?-1452) participated in the editorial supervision. Ryang Seong-ji(1415-1482), Son So(1433-1484), Ryu Yo(?), Han Chi-ryang(?), An Geuk-sang(?), Han Kye-mi(1421-1471), Choi Young-rin(?) took part in the completion of Sejo text. Han Kye-heui(1423-1482), Rym Won-joon(1423-1500), Kueon Chan(1430-1487), Ryu Seo(?), and Baek Soo-heui(?) participated in the completion of Seongjong text. All 96 persons participated in the completion of draft text, revision text, and first-publication text of {Classified Collection of Medical Prescriptions}. 14 persons (14.58 %) participated in the completion of draft text. 77 persons (80.21%) participated in revision text, and 5 persons (5.21%) participated in first-publication text. Even though {Classified Collection of Medical Prescriptions} is a medical book, civil officials participated in its completion together with medical officials. The scholars of Jiphyeonjeon(The Jade Hall of Scholars) who led the academy at those days and famous medical officials were ordered to complete it by Sejong(1419-1450), Sejo(1455-1468), and Seongjong(1470-1494) who showed special interest in thier own heath and the health of common people.
Books/*history ; English Abstract ; History of Medicine, 15th Cent. ; Korea ; *Medicine ; Prescriptions, Drug/*history

For the purpose of understanding the feature of medicine in the late Chosun Dynasty, I investigated Shin Man(1620-1669)'s life and his idea of medicine in Juchonsinbang. Shin Man was a scholar who lived in the middle of the Chosun dynasty. He was famous for his resistance against Ching dynasty in Byeongjahoran, and for his chivalrous spirit. He was daring, inflexible and unrestricted by nature. And his character was reflected in his medical ideas. He studied along Song Si-yeol and started his official career together. Both worked for King Hyojong who strongly wanted to send an expedition to conquer the North. But after the sudden death of King Hyojong, the project to conquer the North had went for nothing. And Shin Man went back to the rural life in Juchon, Jinjam. On the one hand, he lived the life of pursuit of learning Seong Confucianism in Juchon, and on the other hand, he wrote the original form of Juchonsinbang. Shin Man wanted to establish and spread the universal and popularized medicine. So he set a goal to publish a simple and plain prescription book, which corresponds to his idea of medicine which deals with curing people. The currently remaining editions of Juchonsinbang are 3 types. One is the lead printed edition. The others are the dissimilar 2 transcribed editions. There are considerable differences between the lead printed edition and the transcribed editions. The lead printed edition focused on the human being, and divided the category of human being as 3 parts, which are infant, womenkind and adult. Whereas the transcribed editions focused on disorders and aimed at universalization and simplification of medicine. Thus the main viewpoint of medicine changed from disorders to human being. By the way, there are many occult prescriptions in Juchonsinbang. And they aren't distorted with the standpoint of those days. While the time of writing Juchonsinbang has many questionable problems. And there is no historical material which shows the exact time of writing.
Drug Prescriptions/history ; History, 17th Century ; Humans ; Korea ; Philosophy, Medical/history ; *Reference Books, Medical

Traditional Chinese ancient prescriptions have been used for treatment of liver cancer for a long history and the scientific and rational compatibility is a great wealth for modern research and development (R&D) of new drugs. The research and development of new drugs are often accompanied with a large investment, a long cycle and a high risk, especially for the anti-tumor drugs R&D which are facing more risks and lower successful rate. In this research, the regularity of compatibility of drugs was analyzed from 124 anti-hepatoma ancient prescriptions by computer program. The results can offer help to the R&D of anti-hepatoma new drugs and reduce the risk of drug screening. In addition, we surveyed 22 companies in this field from six provinces such as Beijing, Shanghai, Tianjin and so on and obtained 240 risk assessment questionaires. Then we used qualitative analysis method to interpret the greatest impacts for the risks in the process of R&D, production and sales of anti-hepatoma new drugs. The study provides a basis for anti-liver cancer drugs R&D researchers, who can take effective measures to reduce the R&D risks and improve successful rate.
Carcinoma, Hepatocellular ; drug therapy ; history ; China ; Drug Discovery ; history ; Drug Incompatibility ; Drug Prescriptions ; history ; Drugs, Chinese Herbal ; history ; therapeutic use ; History, Ancient ; Humans ; Liver Neoplasms ; drug therapy ; history ; Research ; history

In this paper, menstruation prescriptions were selected from "Fu Qingzhu's Obstetrics and Gynecology" and analyzed by using GRI algorithm, correlation analysis, hierarchical clustering method through SPSS, Clementine and traditional Chinese medicine (TCM) inheritance auxiliary systems, in order to screen out 15 menopathy prescriptions, which involve 45 traditional Chinese medicine herbs. In the study, blood-tonifying and qi-tonifying herbs were found to be frequent in the prescriptions. The most frequent single herb was white paeony root, accounting for 9.6% in the total number of prescriptions; The most frequent herb pairs were white paeony root-radix rehmanniae preparata and paeony root-angelica sinensis. Among Fu Shan's menopathy prescriptions, 61 herbal pairs showed a correlation coefficient exceeding 0.05, which evolved into 16 pairs of core combinations. The analysis showed that menopathy prescriptions in volume 1 of "Fu Qingzhu's Obstetrics and Gynecology" focused on tonic traditional Chinese medicines involving liver, spleen and kidney and were adjusted according to changes in qi, blood, cold, hot and wet, which could provide a specific reference for further studies on Fu Shan's academic thoughts and traditional Chinese medicine clinical treatment of menopathy.
Books ; history ; China ; Drug Prescriptions ; history ; Drug Therapy ; history ; Drugs, Chinese Herbal ; chemistry ; therapeutic use ; Female ; Gynecology ; History, Ancient ; Humans ; Medicine in Literature ; Menstruation ; drug effects

Essential hypertension is one of the most prevalent and important public health concerns in both westernized and developing countries. Recent studies have demonstrated that successful long-term treatment of hypertension has a significant impact on morbidity and mortality from cardiovascular diseases (CVDs) and stroke. Chinese classical formulas, which are important components of traditional Chinese medicine (TCM), have been increasingly accepted by patients with CVDs worldwide. According to TCM theory and syndrome differentiation, hypertension could be categorized into 3 patterns including fire syndrome, fluid retention syndrome, and deficiency syndrome. Chinese classical formulas, including Chaihu Jia Longgu Muli tang, Tianma Gouteng yin, Zhen Gan Xifeng tang, Banxia Baizhu Tianma tang, Liu Wei Dihuang wan, etc, play an important role in the treatment of essential hypertension, which could be further research priorities.
Aged ; China ; Drug Prescriptions ; history ; Drugs, Chinese Herbal ; history ; therapeutic use ; Essential Hypertension ; Female ; History, Ancient ; Humans ; Hypertension ; drug therapy ; history ; Male ; Medicine in Literature ; Middle Aged

The relationship between adjunctive drug (AD) and other drugs in a compound prescription and the actions of AD are very complex. From historical view, it showed the adjunctive action of AD was only be recognized with emphasis on its action as corrigent and effect on complications. In modern medicine, the actions of AD were reduced to 3 aspects: the assistant action, the restrained action and the corrigent action, with new contents added in each aspect on the basis of the ancient understanding. The authors hold that to master the various actions of AD and its relationship with other drugs in the prescription would be helpful in choosing them accurately and scientifically, thus to contribute the treatment in accordance with disease.
China ; Drug Combinations ; Drug Prescriptions ; Drug Synergism ; Drugs, Chinese Herbal ; administration & dosage ; History, 16th Century ; History, 17th Century ; Humans ; Medicine, Chinese Traditional ; history

Theory and mode about compatibility of prescription are the key element for studies on complex prescription in traditional Chinese medicine. In this article, we reviewed the sources, methods and thoughtway about theory of prescription composition, and concluded the current researches about components compatibility. Through introducing the researches about compatibility of effective components, we advanced that components compatibility would be one of the new modes of compound prescription of Chinese medicine. The researches and foundation about the new modes of compound prescription of Chinese medicine would do active influence either in making modern Chinese medicine or in increasing clinical curative effect.
Diagnosis, Differential ; Drug Combinations ; Drug Incompatibility ; Drug Prescriptions ; history ; Drugs, Chinese Herbal ; administration & dosage ; isolation & purification ; History, Ancient ; Humans ; Medicine, Chinese Traditional ; history ; Plants, Medicinal ; chemistry

Huanglian is a commonly used Chinese medicinal herb in the ancient and the present. It has a history of 2000 years in clinical application, having the efficacy of "Clear away heat and remove dampness, purge the sthenic fire and eliminate toxic materials", therefore can be used for various diseases or syndromes in types of dampness-heat and fire-toxin by internal or external use. Compound prescriptions mainly based on Huanglian or prescribed by Huanglian, such as Puji Xiaodu Yin, Huanglian Jiedu Tang, Zhusha Anshen Wan, Qingying Tang, Angong Niuhuang Wan, Niuhuang Qingxin Wan, Jiaotai Wan, Huanglian Ejiao Tang, Zuojin Wan, Danggui Longhui Wan, Huanglian Yanggan Wan, Wu Xiexin Tang, Lianpu Yin, Gegen Huangqin Huanglian Tang, Baitouweng Tang, Xianglian Wan etc. All of these are well-known formulas for clearing away toxin of heat-fire of heart and liver, as well as dampness-heat of stomach and intestines. Nowadays, Huanglian is generally considered as a kind of antibiotic and antivirus herb and is widely used for many infective diseases. In fact, it is also used to cure cardiovascular and cerebrovascular diseases, diabetes and cancer based on pharmacological studies. Having been using Huanglian in treating the above diseases and having conducted clinical and experimental research on cancer and liver diseases, the author observed that Huanglian and its compound prescriptions have obvious effects on liver diseases such as acute or chronic hepatitis, liver fibrosis, liver cirrhosis and liver cancer due to types of dampness-heat and fire-toxin. Part of the effects has been proved by experimental research and it is worth carrying out more research in this area for development and clinical application.
Adult ; China ; Digestive System Diseases ; drug therapy ; Drug Prescriptions ; history ; Drugs, Chinese Herbal ; therapeutic use ; Female ; History, 20th Century ; History, 21st Century ; History, Ancient ; Humans ; Liver Diseases ; drug therapy ; Male ; Medicine, Chinese Traditional ; history ; Middle Aged

OBJECTIVES: Although outbreak of MDR Tb has been a recent problem in western countries, it has been a longstanding problem in Korea. The poor outcome of MDR Tb is mainly due to poor compliance, high rate of side reaction of secondary drugs, and limitation in number of available drugs. Thus, to improve the outcome of MDR Tb,, it is crucial to make individualized adequate prescription based on the knowledge of the patterns of resistance to each drugs in the community as well as the natural history. The purpose of present study is to evaluate the clinical features of Korean MDR Tb patients including patterns of drug resistance and success rate of treatment which was prescribed according to the sensitivity tests. METHODS: Retroscpective analysis of 71 Korean patients with MDR Tb was made. All strains isolated from patients showed resistence to at least two first line drugs. Patients profile, previous treatment history, patterns of drug resistance, outcome of treatment was analysed. Initial treatment regimen was selected according to the previous treatment history and was modified according to the sensitivity reports. The regimen was composed to include at least 4 sensitive drugs when possible. RESULTS: The patients showed resistance to 4.1 drugs on average. 90% of them were resistant to INH and RFP. Among 71 patients, 35 patients(49%) had cavitary lesions in CXR. Treatment outcome was analysed in 55 patients. 35 patients(67%) were improved after treatment and 18 patients(33%) showed treatment failure. 5 patients showed primary resistance. Treatment outcome could be evaluated in 4 of them and all showed improvement after treatment. 14 patients(20%) had to change their regimens due to drug side effects. The most frequent side effect was elevation of liver enzymes(6 patients). Others included dizziness, hyperuricemia, tinnitus, skin rash, GI troubles. More than 50% of side effects developed within 3 months. In repeated drug sensitivity test, the concordance rate of resistance to INH was 100% and RFP 98%. EMB,PZA showed 80% concordance rate. But in the other drugs, the concordances were less than 50%. Operation was done in 5 patients - 1 patients as a adjunctive means of chemotherapy In that case, negative conversion of sputum AFB was done. CONCLUSION: 2/3 patients of multidrug-resistant tuberculosis were improved by appropriate prescription and regular medication suggesting that more aggressive management and monitoring is indicated in multidrug-resistant tuberculosis.
Compliance ; Dizziness ; Drug Resistance ; Drug Therapy ; Exanthema ; Humans ; Hyperuricemia ; Korea ; Liver ; Natural History ; Prescriptions ; Sputum ; Tinnitus ; Treatment Failure ; Treatment Outcome ; Tuberculosis, Multidrug-Resistant*