Humans ; Presbycusis/therapy*

Aging ; Humans ; Presbycusis ; genetics

No Abstract available.
Presbycusis* ; Risk Factors*

No abstract available.
Aged* ; Humans ; Otorhinolaryngologic Diseases* ; Presbycusis

Cognition ; Cognitive Dysfunction ; Humans ; Presbycusis

Humans ; Language Development Disorders ; complications ; Presbycusis ; complications

No abstract available.
Aged* ; Hearing Aids* ; Hearing* ; Humans ; Presbycusis* ; Rehabilitation*

There were many instances in which glaucoma, esp. primary, combined with hearing disturbance. The etiology of these cases has not been known until now. We had 15 primary glaucoma patients for whom pure tone audiometry wa~ performed, and could find the hearing defect in high tone in 5 cases (1/3 among those patients). The audiometric curve was similar to that in the presbycusis, but severer in degree than that occured within the normal physiological aging process. The average age was 62.4 year in the group with the hearing defect, and 45.6 year in the group without the hearing defect. There were no relationship between the hearing defect and intraocular tension, visual field change, glaucomatous cupping, and duration of glaucoma. These results may support the opinion of the authors that the hearing disturbance in glaucomatous patients is related to the arterioscIerotic changes which aggrevate the presbycusis, and not related to glaucoma itself. On the otherhand, however, it is stilI impossible for us to rule out that the pleiotropic and multifactorial genetic factors may play as a common important role in the hearing disturbances and glaucoma. And further studies would be necessary for these problems.
Aging ; Audiometry ; Glaucoma* ; Hearing* ; Humans ; Presbycusis ; Visual Fields

As the population is aging, the prevalence of presbycusis is increasing proportionally. The prevalence of tinnitus, which usually accompanies presbycusis, is also growing. Presbytinnitus, defined as tinnitus which accompanies presbycusis, not only influences the individual's well-being and productivity but also causes communication problems, isolation, and social withdrawal. We now need to adopt more aggressive approaches to treating presbytinnitus in the elderly population, rather than giving them discouraging comments on the course of disease progression. Although the exact mechanisms of presbytinnitus have not been revealed and the specified therapeutic methods have not yet been established, an increasing number of studies using masking, retraining therapy, psychological therapy, and some medications have shown promising outcomes for the management of presbytinnitus. Therefore, appropriate treatment with multidisciplinary modalities should be provided for patients with presbytinnitus in order to reduce a growing social burden.
Aged ; Aging ; Disease Progression ; Efficiency ; Humans ; Masks ; Presbycusis ; Prevalence ; Tinnitus

Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging, in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time points. Overall, our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging, highlights unexpected age-related transcriptional fluctuations in intermediate cells localized in the stria vascularis (SV) and demonstrates that upregulation of endoplasmic reticulum (ER) chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with aging. Our work suggests that targeting unfolded protein response pathways may help alleviate aging-related SV atrophy and hence delay the progression of ARHL.
Mice ; Animals ; Transcriptome ; Aging/metabolism* ; Cochlea ; Stria Vascularis ; Presbycusis