Analysis of 1.701 cases of children mortality under 14 years old at 7 districts and Thai Binh city, from January 1998 to December 2000. The results: early neonatal mortality (< 7days) or a part of prenatal mortality accounted for 35.3%; neonatal mortality 41.6%, children mortality under 1 year old: 57.6%; children mortality under 5 years old: 83.5% compared with children mortality total under 14 years old. Children mortality rate under 1 year old was 13.22%o; Children mortality rate under 5 years old trended to decrease from 23.3%o (1998) to 17.5%o (2000). The main causes of children mortality was cerebral diseases, meninges diseases; respiratory diseases, cardiovascular disease; then some accidents as drowning, electric shock, traffic accident and the third was premature birth
Child ; Mortality ; Cerebral Arterial Diseases ; Premature Birth

The study was carried out on 58 premature newborn underweight babies at the Department of Rehabilitation of Pediatric Hospital, HCM City from Jan 1999 to May 2002. The babies have been monitored from the first 12th hour after birth to the discharge day of hospital. Results showed that premature newly born underweigh babies with disturbance of oxygene metabolism and acidosis blood metabolism had got the higher fatal versus the omes who had not. The ealier correcting of these disturbances will help to improve the mortality. It should increase the early use of surfactants at the Department of neonatal rehabilitation to reduce the risks of internal membranous disorders.
Mortality ; Risk factors ; Infant, Low Birth Weight ; Premature Birth ; Infant, Premature

Preterm birth (PTB) remains a major cause of neonatal mortality and morbidity, despite improvements in tocolytic treatment and neonatal care. Progesterone (17a-hydroxyprogesterone) produced naturally or synthetically can prevent PTB when applied vaginally and orally. Progesterone use may be a safe and cost-effective option in cases of singleton pregnancy with prior PTB, asymptomatically short cervix and arrested preterm labor.
Cervix Uteri ; Female ; Humans ; Infant ; Infant Mortality ; Obstetric Labor, Premature ; Pregnancy ; Premature Birth ; Progesterone ; Tocolysis

Preterm birth is a major cause of neonatal morbidity and mortality, and occurs in 5% to 15% of all pregnancies. Therefore, its prevention is a major opportunity to reduce medical costs and to promote public health in all countries. Preterm birth is a broad great obstetric syndrome that arises from a wide variety of causes. Although many therapeutic agents are used for premature labor, most of them have serious maternal side effects, and they are ineffective in cases when labor has already begun. Therefore, the authors would like to introduce progesterone, as a treatment to prevent preterm labor. We also investigated whether nifedipine, which is used to treat preterm labor, could prevent preterm labor. We are eager to find more effective and easier-to-use drugs to prevent preterm labor in the future.
Female ; Mortality ; Nifedipine ; Obstetric Labor, Premature ; Pregnancy ; Premature Birth ; Preventive Medicine ; Progesterone ; Public Health

At Il Sin Women's Hospital from January 1st to June 30th 1978 there were 463 preterm deliveries(Less than 38 weeks Gestation). 161 of these were between 28-36 weeks gestatin. To study the effect of Dexamethasone in preventing respiratory distress syndrome(R.D.S.) 39 mothers received Dexamethasone before delivery and 85 comparable babies were placed in the control group. 1. R.D.S. was seen in 4(10%) of the treatment group and 12(14%)of the control group. In the control group there is a slightly higher incidence but as the bumbers are small it is difficult to compare with western countreis 2. When comparing the 2 groups the incidence of R.D.S. is greatest in less than 32 weeks gestation. 3. Apgar Scoring is similar in both groups. 4. When Dexamethasone was given for greater than 48 hours the incidence of R.D.S. was less 5. Mortality rate is 10% in treatment group and 24% in control group but majority of deaths are due to severe birth hypoxia or very low birth weight (less than 1000 Gms) 6. The overall incidence of R.D.S. in Il Sin Women's hospital was 29 during the 6 months. This is 0.9% of all livebirths and 6.2% of preterm births being low compared with western countries.
Anoxia ; Dexamethasone* ; Humans ; Incidence ; Infant, Very Low Birth Weight ; Mortality ; Mothers ; Parturition ; Pregnancy ; Premature Birth

Premature birth is the single largest cause of perinatal mortality and morbidity in nonanomalous infants in developing countries. Advances in neonatal care have lead to increased survival and reduced short and long term morbidity for preterm infants. but the rate of preterm birth has actually increased. This review provides recent multifactorial approaches to treatment and prevention of preterm birth.
Developing Countries ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Obstetric Labor, Premature* ; Perinatal Mortality ; Pregnancy ; Premature Birth

OBJECTIVE: To investigate the preterm labor & preterm infants care in Kwangju and Chonam. METHODS: A study was conducted for 2,360 newborns who were born at four main hospitals in Kwangju and chonam from January 1, 1995 to December 31, 1997. Data were collected by review of hospital records. RESULTS: 1. The survival rate was 6.90% at 23~34 weeks, 38.60% at 27~28weeks and 90.67% after 31wks. 2. The survival rate divided according to birth weight were 8.89% below 1,000gm, 57.14% in 1,001~1,500gm, 86.75% in 1,501~2,000gm and 93.37% over 2,000gm respectively. 3. Clinical causes of neonatal death were RDS(48.84%) hyperbilirubinemia (20.74%), sepsis(11.95%) and pneumonia(9.67%). 4. Incidence of RDS was 23.22% and it's neonatal mortality was 36.28%. CONCLUSION: The survival rate of preterm birth in Kwang-Ju and Chon-nam was still lower than data from advancing countries, and main cause of neonatal death was respiratory distress syndrome.
Birth Weight ; Female ; Gwangju* ; Hospital Records ; Humans ; Hyperbilirubinemia ; Incidence ; Infant ; Infant Mortality ; Infant, Newborn ; Infant, Premature* ; Obstetric Labor, Premature ; Pregnancy ; Premature Birth ; Survival Rate

The present study compares neonatal outcome after preterm delivery of infants in pregnancies complicated by the HELLP syndrome or severe preeclampsia (PS). The maternal and neonatal charts of 71 out of a total of 409 pregnancies that were complicated by hypertensive disorders at Severance hospital between January 1995 and December 2004 were reviewed. Twenty-one pregnancies were complicated by HELLP syndrome and 50 pregnancies were complicated by PS. Fifty normotensive (NT) patients who delivered because of preterm labor comprised the control group. Results were analyzed by the chi-square test and ANOVA. Gestational age and maternal age at delivery were matched among the three groups. The neonatal outcomes of the HELLP syndrome group were compared with the PS and NT groups. There were significant differences between the HELLP syndrome group and the PS group in the incidence of intraventricular hemorrhage (IVH) (61.9% vs. 26%, p=0.006), sepsis (85.7% vs. 44%, p =0.003) and mechanical ventilation (MV) rate (81% vs. 54%, p=0.039). There were significant differences between the HELLP syndrome group and the NT group in the incidence of neonatal death (ND) (19.5% vs. 2.0%, p=0.034), respiratory distress syndrome (RDS) (38.1% vs. 8%, p=0.0045), IVH (61.9% vs. 4%, p < 0.0001), sepsis (85.7% vs. 14%, p < 0.0001), intensive care (IC) (85.7% vs. 24%, p < 0.0001) and MV rate (80.1% vs. 14%, p < 0.0001). There were also significant differences between the PS and NT groups in the incidence of ND (20% vs. 2%, p=0.0192), RDS (30% vs. 8%, p=0.0085), IVH (26% vs. 4%, p=0.0070), sepsis (44% vs. 14%, p=0.0015), IC (78% vs. 24%, p < 0.0001), MV rate (54% vs. 14%, p < 0.0001) and low 5-min APGAR score (50% vs. 16%, p=0.0005). This study shows increased morbidity in newborns of mothers complicated with HELLP syndrome and indicates that early, regular and high quality management of these patients is essential to improve both maternal and neonatal outcome.
Premature Birth/*mortality ; Pregnancy Outcome/*epidemiology ; Pregnancy ; Pre-Eclampsia/mortality ; Male ; Infant, Newborn ; Humans ; HELLP Syndrome/*mortality ; Female ; Adult

Premature labor remains one of the most intractable risk factors that contribute to perinatal morbidity and mortality. Tocolytics, antibiotics and corticosteroid have been used as the typical management for preterm labor. Various treatment of women with signs and symptoms of preterm labor has failed to decrease in the incidence of preterm births in the world. The management of preterm labor remains very controversial problems today. There are no clear "first-line" tocolytic drugs and antibiotics to prolong gestation period and improve perinatal outcome. But in Royal College of Obstetricians and gynecologists (RCOG) recommend that atosiban and nifedipine appear to be preferable as they have fewer side effects and seem to comparable effectiveness. So far there is insufficient evidence for any firm conclusions about whether or not maintenance tocolytic therapy following preterm labor is valuable. In conclusion, clinical circumstances and physician preferences should dictate treatment. Individual approach or combined treatment for preterm labor may be helpful in determining which treatment is suitable to each patient.
Anti-Bacterial Agents ; Female ; Humans ; Incidence ; Mortality ; Nifedipine ; Obstetric Labor, Premature* ; Pregnancy ; Premature Birth ; Risk Factors ; Tocolysis ; Tocolytic Agents

Although the survival of preterm infants has improved with advances in perinatal care, the occurrence of cerebral palsy has increased further, because infants who would previously have died now survive with their cerebral pathology. In several observational studies, preterm infants whose mothers received magnesium sulfate were reported to have marked reductions in cerebral palsy, as compared with infants of untreated mothers. From meta-analyses of 5 randomized controlled trials of magnesium sulfate therapy given to the mother prior to very preterm birth, magnesium sulfate reduced the rate of cerebral palsy by approximately 30% (relative risk [RR] 0.68, 95% confidence interval [CI] 0.54-0.87) and moderate to severe cerebral palsy (by 40-45%) without increasing the rate of death in 6,145 infants (RR 10.4, 95% CI 0.92-1.17). Given the relative safety of magnesium sulfate for the mother and the lack of evident risk regarding infant mortality, magnesium sulfate should be considered for use as a neuroprotectant in the setting of anticipated preterm birth.
Cerebral Palsy ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Infant, Premature* ; Magnesium Sulfate* ; Magnesium* ; Mothers ; Pathology ; Perinatal Care ; Premature Birth