To evaluate the predictive value of serum fibronectin and roll-over test for pregnancy induced hypertension (PIH), we studies 79 patients between the twenty-eighth and thirty-second week of gestation from October 1995 to May 1996. The results were as follows . 1) There was no significant difference of mean diastolic pressure difference in roll-over test and serum fibronectin levels between 13 PIH patients and 66 controls. Between two groups of patients, mean diastolic blood pressure differences were 14.3+/-3.9mmHg, 12.0+/-4.4mmHg and mean serum fibronectin levels were 231.2+/-90.8 pg/ml, 196.5+/-61.2 pg/ml respectively(p> 0.1). 2) For prediction of PIH, the sensitivity, the positive predictive value and the negative predictive value of roll-over test were 8%, 14% and 83%.
Blood Pressure ; Female ; Fibronectins* ; Humans ; Hypertension, Pregnancy-Induced* ; Pregnancy ; Pregnancy*

No abstract available.
Equidae* ; Female ; Fetal Blood* ; Pregnancy ; Pregnancy Outcome* ; Pregnancy* ; Ultrasonography*

No abstract available.
Blood Donors* ; Female ; Humans ; Pregnancy ; Pregnancy Trimester, Third* ; Pregnancy*

No abstract available.
Blood Platelets* ; Female ; Hypertension, Pregnancy-Induced* ; Pregnancy ; Pregnancy*

OBJECTIVETo investigate the blood lead levels (BLLs) in the duration of pregnancy and 6-12 weeks after delivery, and analyze the influencing factors of BLLs in healthy pregnant women.

METHODSPregnant women were recruited from September 2009 to February 2010 at the prenatal clinic in Nanjing Maternity and Child Health Care Hospital. Altogether 174 healthy pregnant women without pregnant or obstetric complications or abnormal pregnancy outcomes were enrolled as the gravida group, and 120 healthy non-pregnant women as the control group. BLLs during pregnancy were determined by flame atomic absorption spectroscopy.

RESULTSBLLs in all the three pregnancy trimesters and postpartum were 59.8±24.3, 55.4±20.1, 55.9±19.7, and 67.6±17.4 μg/L, respectively, and the mean BLL in control group was 67.5±21.3 μg/L. BLLs during all the three trimesters were lower in the gravida group than in the control group (P=0.043, 0.021, and 0.028). Furthermore, occupations, nutrients supplementation, and time of house/apartment painted were associated with BLLs in pregnant women. Lead-related occupations, cosmetics use, and living in a house painted less than 1 year before are risk factors of high BLLs among pregnant women, while calcium, iron, zinc, and milk supplements are protective factors.

CONCLUSIONSupplementing calcium, iron, zinc, and milk, or avoiding contact with risk factors may help people, especially pregnant women, to reduce lead exposure.

Adult ; Female ; Humans ; Lead ; blood ; Pregnancy ; blood

OBJECTIVETo study the relationship between pregnancy-induced hypertension (PIH) and catecholamine levels.

METHODSCatecholamines levels in maternal and fetal blood were determined in 116 patients with PIH and 40 normal control subjects using high performance liquid chromatography. The normal control subjects and PIH cases were selected from patients at term pregnancy receiving elective cesarean section.

RESULTSPlasma norepinephrine (NE) levels were significantly higher in patients with severe PIH than those in control subjects (P < 0.05). Both patients and control subjects had higher NE levels in the umbilical artery blood than in the umbilical vein blood (P < 0.05). NE levels in the umbilical artery blood were five times higher than those in the maternal blood.

CONCLUSIONThe pathogenesis of PIH may relate to catecholamine concentrations in fetus.

Catecholamines ; blood ; Female ; Fetus ; physiopathology ; Humans ; Hypertension ; blood ; Pregnancy ; Pregnancy Complications, Cardiovascular ; blood

OBJECTIVETo investigate the alteration of serum resistin levels in normal pregnancy and preeclampsia.

METHODSBlood samples were take from 28 normal non-pregnant women, 27 women in the 1st, 26 in the 2nd and 26 in the 3rd trimester of normal pregnancy and 25 women with preeclampsia. Serum resistin concentration was determined using ELISA method.

RESULTSerum levels of resistin were not significantly different among non-pregnancy, the 1st and the 2nd trimester of pregnancy (P>0.05 for all). Serum resistin level was significantly elevated in the 3rd trimester of pregnancy as compared with non-pregnancy (P<0.01), the 1st (P<0.001) and the 2nd trimester of pregnancy (P<0.001). Serum resistin level was significantly lower in preeclampsia than in the 3rd trimester of normal pregnancy (P<0.001), but was comparable to that of non-pregnancy, the 1st and the 2nd trimester of pregnancy (P>0.05 for all).

CONCLUSIONThe decrease of serum resistin level in the preeclampsia may provide insight into the pathogenesis of the disease.

Adult ; Female ; Glucose Tolerance Test ; Humans ; Pre-Eclampsia ; blood ; Pregnancy ; Pregnancy Trimester, Third ; blood ; Resistin ; blood

Adult ; Blood Coagulation ; Female ; Fibrinolysis ; Hepatitis B, Chronic ; blood ; Humans ; Pregnancy ; Pregnancy Complications, Infectious ; blood ; Pregnancy Trimester, Third ; Young Adult

BackgroundFacing the increasing prevalence of gestational diabetes mellitus (GDM), this study aimed to evaluate the management of GDM and its association with adverse pregnancy outcomes.

MethodsThe data of 996 inpatients with GDM who terminated pregnancies in our hospital from January 2011 to December 2015 were collected. Treatments during pregnancy and the last hospital admission before delivery were analyzed. Pregnancy outcomes of the GDM patients were compared with 996 nondiabetic subjects matched by delivery year and gestational age. The association between fasting plasma glucose (FPG) and adverse pregnancy outcomes was examined by logistic regression analyses.

ResultsThe average prevalence of GDM over the 5 years was 4.4% (1330/30,191). Within the GDM patients, 42.8% (426/996) received dietary intervention, whereas 19.1% (190/996) received insulin treatment. Adverse outcomes were more likely to occur in patients with unsatisfactory control of blood glucose such as respiratory distress syndrome (RDS, χ = 13.373, P < 0.01). Elevated FPG was identified as an independent risk factor for premature birth (odds ratio [OR] = 1.460, P < 0.001), neonatal care unit admission (OR = 1.284, P < 0.001), RDS (OR = 1.322, P = 0.001), and stillbirth (OR = 1.427, P < 0.001).

ConclusionsManagement of GDM in the real world of clinical practice was unsatisfactory, which might have contributed to adverse pregnancy outcomes.

Blood Glucose ; analysis ; Diabetes, Gestational ; blood ; Female ; Humans ; Pregnancy ; Pregnancy Complications ; blood ; Pregnancy Outcome ; Retrospective Studies ; Risk Factors

The pathogenesis of thrombocytopenia in the gestational thrombocytopenia is not understood.This syndrome may represent either the de novo development of ITP or an accelerationof the physiologic pattern of increased platelet destruction that occurs during gestation. Thisdisorder is not easily distinguishable from classical ITP. However, the recognition and diagnosisof this syndrome is important because infants born to individuals with gestational thrombocytopeniaappear to have a markedly reduced risk of developing thrombocytopenia when comparedto infants born to patients with a history of ITP antedating pregnancy. We represent a caseof delivery in severe gestational thrombocytopenia with brief review of the literature.
Blood Platelets ; Humans ; Infant ; Pregnancy ; Thrombocytopenia*