Spirulina is a freshwater blue-green microalgae which has been used as a food supplement for centuries. It is a rich source of several macro- and micro-nutrients. Several studies have demonstrated the potential nutraceutical, pharmaceutical and health benefits of Spirulina. The focus of this article is to highlight the multiple potential roles of Spirulina in human health. Studies have demonstrated Spirulina's roles in boosting immunity through increasing resistance to various infections. Potential health benefits of Spirulina in association with its antioxidant, antiviral and anti-inflammatory properties have also been reported. Owing to its nutrient profiles and nutraceutical properties, Spirulina has been shown to have potential therapeutic roles in metabolic diseases, hypertension, anaemia, and acquired immune deficiency syndrome

Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the maintenance of the various other physiological processes. Aging is accompanied by a decrease in the resistance to environmental stress, while mitochondria are primary targets in the process of aging, their expression decreasing with age. Mitochondrion also plays a significant role in the process of spermatogenesis. HSPs have been shown to be involved in apoptosis with some of acting as apoptotic inhibitors and are involved in cytoprotection. In this review we discuss the roles of Hsp 27, 60, 70, and 90 in aging and male infertility and have concluded that these particular HSPs can be used as a molecular markers for mitochondrially- mediated apoptosis, aging and male infertility.
Aging* ; Apoptosis* ; Cytoprotection ; Fertility* ; Heat-Shock Proteins* ; Homeostasis ; Humans ; Infertility, Male ; Male ; Mitochondria ; Physiological Processes ; Protein Isoforms* ; Spermatogenesis