1.Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Pranavi KOPPULA ; Li ZHUANG ; Boyi GAN
Protein & Cell 2021;12(8):599-620
The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers. Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis, a form of regulated cell death induced by excessive lipid peroxidation. However, cancer cells with high expression of SLC7A11 (SLC7A11
2.Cytochrome P450 reductase (POR) as a ferroptosis fuel.
Pranavi KOPPULA ; Li ZHUANG ; Boyi GAN
Protein & Cell 2021;12(9):675-679
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