PURPOSE: To compare respiratory and clinical outcomes between the currently used strategy of Intubation, Surfactant, Extubation (InSurE) and nasal continuous positive airway pressure (NCPAP) and the alternative strategy of InSurE and nasal intermittent positive pressure ventilation (NIPPV) for the initial treatment of respiratory distress syndrome (RDS) in preterm newborns < or =32 weeks. METHODS: Twenty-six comparable preterm infants with RDS were included in the study; 13 were randomized to NCPAP and 13 to NIPPV. In both groups, the InSurE procedure consisted of intubation, surfactant instillation and 2 h positive pressure ventilation followed by extubation, after which spontaneously breathing newborns were placed on NCPAP or NIPPV. RESULTS: There were no differences in demographic characteristics or cardiorespiratory status among preterm infants enrolled in the study. The reinutation rate was lower among the infants treated with NIPPV than among those on NCPAP (8% vs. 46%, P<0.05) and the rate of aminophylline use between 4 and 7 days of age of was lower in the NIPPV group compared to the NCPAP group (8% vs. 30%, P<0.05). In addition, "InSurE with NIPPV" significantly reduced the overall duration of endotracheal ventilation and shortened the time to first feed compared to "InSurE with NCPAP". CONCLUSION: "InSurE with NIPPV" displayed therapeutic benefits as the initial treatment of preterm RDS when compared with the currently used ventilator strategy, "InSurE with NCPAP" by preventing re-intubation and shortening the duration of endotracheal ventilation.
Aminophylline ; Continuous Positive Airway Pressure* ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intermittent Positive-Pressure Ventilation* ; Intubation ; Pilot Projects* ; Positive-Pressure Respiration ; Prospective Studies* ; Respiration ; Ventilation ; Ventilators, Mechanical

BACKGROUND: The purpose of this study was to measure lumbar epidural pressure (EP) during the insertion of a Tuohy needle under general anesthesia and to evaluate the influence of airway pressure on EP. METHODS: Lumbar EP was measured directly through a Tuohy needle during intermittent positive pressure ventilation in fifteen patients. Mean and peak EP were recorded after peak inspiratory pressures (PIP) of 0, 15, and 25 cmH2O. RESULTS: All measured lumbar EPs were positive, with the pressure increasing during inspiration and decreasing during expiration. Median EP was 6.0 mmHg (interquartile range, 4.0-8.0) at 0 cmH2O of PIP, 6.5 mmHg (4.5-8.5) at 15 cmH2O, and 8.5 mmHg (6.0-10.5) at 25 cmH2O, increasing significantly at 15 cm H2O PIP, and further increasing at 25 cmH2O (P < 0.001). CONCLUSIONS: We demonstrate the influence of increased airway pressure on lumbar EP measured directly through a Tuohy needle. Lumbar EPs were positive, and increasing PIP levels significantly increased lumbar EP.
Anesthesia, General ; Humans ; Intermittent Positive-Pressure Ventilation ; Needles ; Positive-Pressure Respiration

BACKGROUND: It is invasive and accompanies various risks to insert pulmonary artery catheter in order to measure mixed venous oxygen saturation (SvO2) that is associated with patients clinical course and prognosis. If there is relationship between central venous oxygen saturation (ScvO2) and mixed venous oxygen saturation, we can use the central venous oxygen saturation instead of mixed venous oxygen saturation to monitor and treat patients. METHODS: We inserted the Swan-Ganz catheter in 20 patients (male 8, female l2) scheduled for undergoing open heart surgery and accomplished the blood gas analysis of the radial arterial blood, central venous blood and mixed venous blood during postoperative respiratory care in intensive care unit at F1O2 1.0, 0.6 and 0.4 in order. RESULTS: There was no significant difference between central venous blood and mixed venous blood in respect to pH, PCO2, PO2. except the mixed venous blood pH at F1O2 0.6 that is greater than the central venous blood pH at F1O2 0.6. Central venous oxygen saturation and mixed venous saturation were not significantly different and showed the following close relationship: SvO2(%)=15.41+0.80XScvO2 (R=0.88, p<0.05). In respect to the difference according to the variation of F1O2, the SO2 and PO2 at F1O2. 1.0 were higher than the SO2 and PO2 at F1O2 0.6 and 0.4, but the differnce between F1O2 0.6 and 0.4 was not significant. CONCLUSIONS: We might conclude that central venous oxygen saturation might be replaced for the mixed venous oxygen saturation in respiratory care after open heart surgery in adults.
Adult ; Blood Gas Analysis ; Catheters ; Female ; Humans ; Hydrogen-Ion Concentration ; Intensive Care Units ; Intermittent Positive-Pressure Breathing ; Oxygen* ; Prognosis ; Pulmonary Artery ; Respiration, Artificial* ; Thoracic Surgery ; Ventilation

OBJECTIVE: To consider the utility of non-invasive positive pressure ventilation (NIPPV) support during percutaneous gastrostomy procedure in amyotrophic lateral sclerosis (ALS) patients with severe respiratory insufficiency and weight loss. METHOD: Percutaneous gastrostomy was performed in 25 ALS patients with forced vital capacity (FVC) below 50% of predicted normal value. NIPPV was applied to all these patients during the procedure. To estimate the utility of NIPPV application during gasrtostomy tube placement, safety and procedure related complications were investigated. RESULTS: Percutaneous endoscopic gastrostomy (PEG) was performed successfully in 21/25 patients (84%). Percutaneous radiologic gastrostomy (PRG) was performed to the rest. FVCP (predicted value of FVC) in seated position were 1,239.1 ml (32.1%) in PEG-successful group and 1,065.0 ml (26.8%) in PEG-failed group, respectively. All the patients tolerated the use of NIPPV successfully and there were no respiratory complications with the procedure. There were no major complications and procedure-related mortality in all the patients. CONCLUSION: NIPPV support during percutaneous gastrostomy tube placement could make the procedure possible in ALS patients with very low vital capacities.
Amyotrophic Lateral Sclerosis ; Deglutition Disorders ; Gastrostomy ; Humans ; Intermittent Positive-Pressure Ventilation ; Positive-Pressure Respiration ; Reference Values ; Respiratory Insufficiency ; Vital Capacity

Among patients scheduled for elective surgery at the Kyung Hee University Hospital, 15 patients undergoing open thoracotomy were selected. Two different ventilatory modes were employed and compared to the one-lung ventilation(control). First, 10 cmH2O of continuous positive airway pressure was applied to the unventilated lung while patients were under one lung ventilation with 50% oxygen(CPAP 10 cmH2O). Second, 10 cmH2O of positive end expiratory pressure to the ventilated lung and 10 cmH2O of continuous positive airway pressure to the unventilated lung were applied while patients were under one lung ventilation with 50% oxygen(CPAP/PEEP). Arterial oxygen tension, alveolar-arterial oxygen difference (A-aDO2) and intrapulmonary shunt fraction of two different ventilatory modes were observed and compared to control group, and CPAP/PEEP group to CPAP 10 cmHO group. The RESULTs were as followed: 1) Mean PaO2 in CPAP 10 cmH2O and CPAP/PEEP were 138+/-42 mmHg and 177+/-44 mmHg, respectively, and were significantly increased as compared to 100+/-29 mmHg of control group(P<0.05). Comparing the PaO2 of CPAP 10 cmH2O and CPAP/PEEP, there was statistically significant increase in CPAP/PEEP(P<0.05). 2) A-aDO2 in CPAP 10 cmH2O and CPAP/PEEP were 175+/-43 mmHg and 131+42 mmHg, respectively, and were significantly decreased as compared to 213+/-32 mmHg of control group(P<0.05). Shunt percentages(Qsp/QT) were measured as 23.7+/-5.8% in control group, 18.3+/-6.0% in CPAP 10 cmH2O, 13.0+/-4.3% in CPAP/PEEP. Shunt percentages of CPAP 10 cmH2O and CPAP/PEEP were decreased significantly as compared to the control group(P<0.05). Comparing the A-a DO2 and the shunt percentages of CPAP 10 cmH2O and CPAP/PEEP, there was statistically significant decrease in CPAP/PEEP(P<0.05). Based on the above RESULTs, the application of appropriate continuous positive airway pressure to the unventilated lung and 10 cmH2O of positive end expiratory pressure to the ventilated lung during one lung ventilation is thought to be more effective than only continuous positive airway pressure to the unventilated lung in preventing hypoxemia.
Anoxia ; Continuous Positive Airway Pressure ; Humans ; Lung ; One-Lung Ventilation* ; Oxygen* ; Positive-Pressure Respiration ; Thoracotomy

BACKGROUND: Noninvasive ventilation has been used extensively for the treatment of patients with neuromuscular weakness or restrictive chest wall disorders complicated by hypoventilatory respiratory failure. Recently, noninvasive positive pressure ventilation has been used in patients with alveolar hypoventilation,chronic obstructive pulmonary disease(COPD),and adult respiratory distress syndrome. Sanders and Kern reported treatment of obstructive sleep apnea with a modification of the standard nasal CPAP device to deliver seperate inspiratory positive airway pressure(IPAP) and expiratory positive airway pressure(EPAP).Bi-level positive airway pressure (BiPAP) unlike nasal CPAP, the unit delivers a different pressure during inspiration from that during expiration The device is similar to the positive pressure ventilator or pressure support ventilation. METHOD AND PURPOSE: Bi-level positive airway pressure(BiPAP) system(Respironics, USA) was applied to seven patients with acute respiratory failure and three patients on conventional mechanical ventilation. RESULTS: 1) Two of three patients after extubation were successfully achieved weaning from conventional mechanical ventilation by the use of BiPAP ventilation with nasal mask. Five of seven patients with acute respiratory failure successfully recovered without use of conventional mechanical ventilation. 2) PaO2 lhour after BiPAP ventilation in acute respiratory failure patients significantly improved more than baseline values(p<0.01)). PaCO2 lhour after BiPAP ventilation in acute respiratory failure patients did not change significantly more than baseline values. CONCLUSION: Nasal mask BiPAP ventilation can be one of the possible alternatives of conventional mechanical ventilation in acute respiratory failure and supportive method for weaning from mechanical ventilation.
Humans ; Intermittent Positive-Pressure Ventilation* ; Masks ; Noninvasive Ventilation ; Positive-Pressure Respiration ; Respiration, Artificial ; Respiratory Distress Syndrome, Adult ; Respiratory Insufficiency ; Sleep Apnea, Obstructive ; Thoracic Wall ; Ventilation ; Ventilators, Mechanical ; Weaning

Tension pneumothorax (PTx) was diagnosed in a preterm baby during surgery for tracheoesophageal fistula (TEF). The PTx occurred around 90 minutes after skin incision, while the baby was breathing spontaneously with intermittent positive pressure ventilation (PPV) at low pressure. A sudden decrease in oxygen saturation (SpO2), hemodynamic compromise, and decreased breath sounds on the right side suggested a right-sided tension PTx. After prompt radiological confirmation, needle aspiration of air through the surgical site restored the patient's condition immediately. Although the sudden unexpected hypoxemia and circulatory problems may confuse anesthesiologists, prompt diagnosis and proper treatment are required for successful clinical outcomes in tension PTx.
Anoxia ; Diagnosis ; Hemodynamics ; Intermittent Positive-Pressure Ventilation ; Needles ; Oxygen ; Pneumothorax* ; Respiration ; Skin ; Tracheoesophageal Fistula*

OBJECTIVETo study the effects of expiratory triggering sensitivity (ETS) on patient-ventilator expiratory synchrony and work of breathing in chronic obstructive pulmonary disease (COPD) patients during pressure support ventilation (PSV).

METHODSA total of 31 COPD patients were ventilated in PSV mode, and measured by a pulmonary monitor. Meanwhile, the electromyogram of the diaphragm (EMG(diaph)) was obtained with electromyography. Five levels of ETS, 1%, 15%, 25%, 35%, and 50% of peak inspiratory flow (PIF), were studied in random order. Each ETS level lasted 30 minutes and all the data were recorded simultaneously for 3 minutes at the end of each period. The effects of ETS on patient-ventilator expiratory synchrony were analyzed by measuring the phase angle of expiration between the EMG(diaph) and the flow wave curve, and the effects of ETS on work of breathing by calculating total work of breathing (Wtot), work of inspiration by patients (Wi, P) and expiratory work of breathing (Wex).

RESULTSTen patients were excluded from the study. At the 25% PIF level of ETS, patient-ventilator expiratory synchrony was the best, theta = (8 +/- 3) degrees, 16 patients - 15 degrees < or = theta < or = 15 degrees, and the amount of Wtot, Wi, p, Wex was the smallest among all the 5 levels of ETS, which was (1.86 +/- 0.53) J/L, (0.54 +/- 0.13) J/L, and (0.16 +/- 0.08) J/L respectively. When the level of ETS decreased, the occurrence of delayed termination of inspiration and the amount of Wex increased. At the level of 1% PIF, 18 patients theta > 15 degrees, and Wex was (0.48 +/- 0.10) J/L; at this level of ETS, Wi, p also increased significantly to (0.65 +/- 0.16 ) J/L. But when the level of ETS increased, the occurrence of premature termination of inspiration and the amount of Wi, p increased: at 50% PIF level of ETS, theta < - 15 degrees and Wi, p was (1.33 +/- 0.14) J/L in 19 patients.

CONCLUSIONThe proper adjustment of ETS during PSV improves patient-ventilator synchrony and decreases work of breathing in COPD patients.

Humans ; Intermittent Positive-Pressure Ventilation ; methods ; Pulmonary Disease, Chronic Obstructive ; physiopathology ; therapy ; Respiration

OBJECTIVETo evaluate the effects of different interventional strategies, namely controlled high-concentration oxygen therapy, continuous positive airway pressure (CPAP) and bi-level positive airway pressure (BiPAP) ventilation, on respiratory response and work of breathing (WOB) in canine models of early-stage acute lung injury (ALI).

METHODSAfter successful duplication of ALI models with oleic acid (diagnostic criteria: Pa(O2)/Fi(O2)

RESULTSBiPAP resulted in the most significant effects in reducing the respiratory rate (RR) and f/V(T) (P<0.001), followed by CPAP and O2 interventions (P<0.001). None of the 3 treatments showed obvious effects on V(E) (P>0.05), which maintained the level of early ALI/ARDS stage. BiPAP greatly improved V(T) and V(T)/Ti, showing better effects than CPAP and O2. No significant differences were noted among the 3 groups in T(I)/T(tot) (P>0.05). BiPAP showed superior effect to CPAP in lowering the peak transdiaphragmatic pressure (Pdi). CPAP and BiPAP both effectively counteracted intrinsic positive end expiratory pressure (PEEPi) (P<0.01), while O2 produced no obvious such effects (P>0.05). BiPAP showed the most evident effects, followed by CPAP, in reducing WOB, but oxygen therapy produced no obvious effects. CPAP (P<0.01) and BiPAP (P>0.05) both effectively reduced the proportion of ingredients in WOB related to PEEPi.

CONCLUSIONBiPAP and CPAP can produce favorable effects in relieving dyspnea, reducing WOB and improving respiratory response to control the deterioration of ARDS. BiPAP has more significant therapeutic effects than CPAP and oxygen therapy.

Acute Disease ; Animals ; Continuous Positive Airway Pressure ; Dogs ; Female ; Lung Diseases ; physiopathology ; therapy ; Male ; Oxygen Inhalation Therapy ; Positive-Pressure Respiration ; Respiration ; Respiration, Artificial ; methods ; Time Factors

BACKGROUND: This randomized, controlled study was designed to compare the effects of recruitment maneuvers (RMs) with a 15 cmH₂O positive end-expiratory pressure (PEEP) on the systemic oxygenation and lung compliance of patients with healthy lungs following robot-assisted laparoscopic prostatectomy (RALP). METHODS: Sixty patients undergoing a RALP with an intraoperative 15 cmH₂O PEEP were randomly allocated to an RM or a Control group. The patients in the RM group received a single RM through the application of a continuous positive airway pressure of 40 cmH₂O for 40 s 15 min after being placed in the Trendelenburg position. The arterial oxygen tension (PaO₂, primary endpoint) and the pulmonary dynamic and static compliances (secondary endpoints) were measured 10 min after the anesthetic induction (T1), 10 min after establishment of the pneumoperitoneum (T2), 10 min after establishment of the Trendelenburg position (T3), 10 min after the RM (T4), 60 min after the RM (T5), and 10 min after deflation of the pneumoperitoneum in the supine position (T6). RESULTS: The intergroup comparisons of the PaO₂ showed significantly higher values in the RM group than in the Control group at T4 and T5 (193 ± 35 mmHg vs. 219 ± 33 mmHg, P = 0.015, 188 ± 41 mmHg vs. 214 ± 42 mmHg, P = 0.005, respectively). However, the PaO₂ at T6 was similar in the two groups (211 ± 39 mmHg vs. 224 ± 41 mmHg, P = 0.442). Moreover, there were no statistical differences between the groups in the dynamic and static compliances of the lungs at any time point. CONCLUSIONS: The arterial oxygenation of the patients with a healthy lung function who had undergone a RALP with intraoperative 15 cmH₂O PEEP was improved by a single RM. However, this benefit did not last long, and it did not lead to an amelioration of the lung mechanics.
Continuous Positive Airway Pressure ; Head-Down Tilt ; Humans ; Lung ; Lung Compliance ; Mechanics ; Oxygen* ; Pneumoperitoneum ; Positive-Pressure Respiration* ; Prostatectomy* ; Supine Position