1.Porphyria cutanea tarda precipitated by alcohol abuse.
Hee Yeon KIM ; Ji Hyun KIM ; Seung Hwan LEE ; Ho Young SON
Korean Journal of Medicine 2007;73(6):670-671
No abstract available.
Alcoholism*
;
Porphyria Cutanea Tarda*
;
Porphyrias*
2.Sporadic Porphyria Cutanea Tarda in a Patient with Multiple Sclerosis Treated with Interferon Beta 1-a Therapy: A Case Report.
Pietro CARRIERI ; Maria PETRACCA ; Silvana MONTELLA ; Giovanni CERULLO ; Ilaria CERILLO ; Gianfranco CIMMINO
Journal of Clinical Neurology 2013;9(3):196-197
No abstract available.
Humans
;
Interferon-beta
;
Interferons
;
Multiple Sclerosis
;
Porphyria Cutanea Tarda
;
Porphyrias
3.Porphyria Cutanea Tarda in a Hemodialysis Patient.
Kee Suck SUH ; Sang Hwa HAN ; Joon Hee KIM ; Kang Hoon LEE ; Jong Bin PARK ; Sang Tae KIM ; Min Soo JANG
Korean Journal of Dermatology 2016;54(1):81-83
No abstract available.
Humans
;
Kidney Failure, Chronic
;
Porphyria Cutanea Tarda*
;
Porphyrias*
;
Renal Dialysis*
4.Four Cases of Porphyria Cutanea Tarda.
Sung Hwa KIM ; Sang Lip CHUNG ; Sang Won KIM
Korean Journal of Dermatology 1983;21(4):421-427
Porphyria cutanea tarda(PCT) is a photocutaneous disorder due to excessive porphyrins in the skin. We experienced 4 male patients who showed typical clinical manifestations. Histologic findings revealed subepidermal bullae with festooned derrnal papi11ae, and typical porphyrin excretion pattern of PCT was detected. One case had on 500mg daily of chloroquine with r.linical and biochemical improvement 4 months later without any adverse effects. Other 2 cases had on 125mg of chloroquine twice a week and the other one had perforrned phlebotomy.
Chloroquine
;
Humans
;
Male
;
Phlebotomy
;
Porphyria Cutanea Tarda*
;
Porphyrias*
;
Porphyrins
;
Skin
5.Porphyria Cutanea Tarda Presenting as Jaundice.
Kwang Hyuk PARK ; Dong Yang PARK ; Jin Bae KIM ; Il Hyun BAEK ; Myung Seok LEE ; Gwang Ho BAIK ; Sang Hoon PARK ; Jong Hyeok KIM ; Choong Kee PARK ; Kwang Ho KIM
The Korean Journal of Hepatology 2004;10(4):308-312
Porphyria cutanea tarda (PCT) is a disease characterized by an early appearance of severe photosensitivity with an increase in urinary uroporphyrin excretion and other porphyrins, high isocoproporphyrin fecal levels and an accumulation of protoporphyrin in erythrocyte. This disease has been known to be caused by a dramatic decrease in the activity of the uroporphyrinogen decarboxylase. Multiple infectious and environmental factors may contribute to PCT by influencing oxidative stress in the hepatocytes. We report here on a case of porphyria cutanea tarda that presented with jaundice and photosensitivity.
Adult
;
English Abstract
;
Humans
;
Jaundice/*complications
;
Male
;
Photosensitivity Disorders/complications
;
Porphyria Cutanea Tarda/complications/*diagnosis
6.A Case of Pseudoporphyria.
Korean Journal of Dermatology 2005;43(3):394-397
Pseudoporphyria is a generic term that is used to describe photoaggravated bullous dermatoses associated with multiple iatrogenic causes, including medications and dialysis. The bullous lesions of pseudoporphyria are similar to those of porphyria cutanea tarda, both clinically and histologically, but they occur in the absence of the abnormally high levels of porphyrins which are found in true porphyrias. Treatment entails discontinuation of suspected agents and sun protection, especially against UVA wavelengths. We report a case of pseudoporphyria in a 28-year-old male who had erythematous crusted erosions, vesicles and hyperpigmented macules on his face and both forearms. A biopsy from his Lt. forearm revealed subepidermal bullaes with festooning of dermal papillae, and mild lymphocytic perivascular infiltrations. However laboratory tests for porphyrin were negative in his urine, blood and stool.
Adult
;
Biopsy
;
Blister
;
Dialysis
;
Forearm
;
Humans
;
Male
;
Porphyria Cutanea Tarda
;
Porphyrias
;
Porphyrins
;
Skin Diseases, Vesiculobullous
;
Solar System
7.Liver Cirrhosis Induced by Porphyria Cutanea Tarda: A Case Report and Review.
Kwang Gyun LEE ; Jong Jin HYUN ; Yeon Seok SEO ; Bora KEUM ; Hyung Joon YIM ; Yoon Tae JEEN ; Hong Sik LEE ; Hoon Jai CHUN ; Chang Duck KIM ; Ho Sang RYU ; Soon Ho UM
Gut and Liver 2010;4(4):551-555
Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity, bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic, and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes, urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.
Blister
;
Erythrocytes
;
Feces
;
Fibrosis
;
Humans
;
Liver
;
Liver Cirrhosis
;
Liver Diseases
;
Liver Failure
;
Porphyria Cutanea Tarda
;
Porphyrias
;
Skin Pigmentation
;
Uroporphyrinogen Decarboxylase
8.A Study of the Relationship between Psoriasis and Viral Hepatitis.
Jae Wang KIM ; Kwang Joong KIM ; Chong Ju LEE
Korean Journal of Dermatology 1998;36(2):266-274
BACKGROUND: Although there are varied etiological factors in the pathogenesis of psoriasis, recent data where viral hepatitis is more frequently found in psoriasis patients than in the normal population, suggests the possibility that some kinds of viral antigens may participate as causative factors of psoriasis. Hepatitis C virus(HCV) in particular, which has been proven to be associated with many dermatoses such as porphyria cutanea tarda, lichen planus and vasculitis, is currently suspected as a possible pathogen in psoriasis. OBJECTIVE: This study was conducted to estimate the prevalence of viral hepatitis infection among psoriasis patients in Korea where it is known to be endemic. Additionally, we analysed the relationship between the clinical severity of psoriasis and viral hepatitis according to the serotypes. METHODS: In this study, we looked for the presence of HCV, HBV, HAV, HDV and HEV infection in 65 enrolled psoriasis patients and 98 non-psoriatic patients by enzyme immunoasay, recombinant immunoblotting, radioimmunoassay and reverse transcription polymerase chain reactions. RESULTS: 1. We found a higher prevalence of viral hepatitis in the psoriasis group(70.8%) than the control group(45.9%). 2. 10.7% of patients were shown to be infected with HCV in the psoriasis group, in comparison with 2% in the control group. Also 52.7% of psoriatic patients were positive to HBV markers as HBcAb and HBsAg in comparison with 38.8% in the control group. 3. There was a statistically significant correlative relationship between the clinical severity of psoriasis and the presence of viral hepatitis. 4. We could establish a significant association among higher titers of ALT, positivity of HBcAb and HBsAg, and HCV hepatitis in psoriatic patients. CONCLUSION: Psoriatic patients had a higher prevalence of viral hepatitis than normal controls. Also psoriatic patients with viral hepatitis showed relatively different clinical features and labaratory results in comparison with those without it.
Antigens, Viral
;
Hepatitis B Surface Antigens
;
Hepatitis C
;
Hepatitis*
;
Humans
;
Immunoblotting
;
Korea
;
Lichen Planus
;
Polymerase Chain Reaction
;
Porphyria Cutanea Tarda
;
Prevalence
;
Psoriasis*
;
Radioimmunoassay
;
Reverse Transcription
;
Skin Diseases
;
Vasculitis
9.A Case of Rapidly Progressive Glomerulonephritis Associated with Hepatitis C Virus.
Chi Hun CHOI ; Kweon Woo HAN ; Kwang Hyuk PARK ; Chull Sung JUNG ; Seong Gyun KIM ; Ji Eun OH ; Jang Won SEO ; Young Ki LEE ; Ja Ryong KOO ; Hyung Jik KIM ; Jung Woo NOH ; Chong Woo YOO
Korean Journal of Nephrology 2004;23(6):1004-1008
Chronic HCV infection has been reported to be associated with several extrahepatic conditions such as cryoglobulinemia, lymphoma, lichen planus, porphyria cutanea tarda, autoimmune thyroiditis, and renal disease. Glomerular disease may occur in patients with chronic HCV infection. The most common patterns are membranoproliferative glomerulonephritis, and less frequently, membranous nephropathy, fibrillary glomerulonephritis and immunotactoid glomerulopathy. Few crescentic glomerulonephritis has been reported in association with HCV infection, and no case was reported in Korea yet. We experienced one case of rapidly progressive glomeruloinephritis with the pathology of crescentic glomerulonephritis complicated in membranoproliferative glomerulonephritis in a patient with HCV infection.
Cryoglobulinemia
;
Glomerulonephritis*
;
Glomerulonephritis, Membranoproliferative
;
Glomerulonephritis, Membranous
;
Hepacivirus*
;
Hepatitis C*
;
Hepatitis*
;
Humans
;
Korea
;
Lichen Planus
;
Lymphoma
;
Pathology
;
Porphyria Cutanea Tarda
;
Thyroiditis, Autoimmune
10.A Case of porphyria Cutanea Tarda.
Korean Journal of Dermatology 1973;11(3):171-177
Porphyria is a rare metabolic disorder in this country and a few cases of acute intermittent porphyria has been reported. We observed a case of porphyria cutanea tarda associated with liver cirrhosis. The patient was 61-year-old farmer with heavy alcoholic habit. He had been suffered from skin fragility and photosensitivity for 3 years. His face color was slate blue and sclerdermoid appearance noted especially on the cheek. Bullae, which is healing slowly and followed by atrophic pigmented scars, were developed on the dorsum of hand and feet after receiving trivial trauma and massive alcohol intake. None of his family members has similar symptoms. Urine specimen showed port-wine coIor and fluoresced pinkish under the Wood's light. Serum iron level was markedly elevated (400 microgram%). The other abnormal findings of liver function test were BSP retention (16%/45min.), elevated SGOT (198 unit) and SGPT (80 unit) levels. Esophagram revealed suspicious of varices and liver scanning showed cirrhotic changes. Skin biopsy specimens taken from the cheek and dorsum of hand showed sclermoid changes and subepidermal bulla. Liver biopsy disclosed mild degree of cirrhotic changes.
Alanine Transaminase
;
Alcoholics
;
Aspartate Aminotransferases
;
Biopsy
;
Cheek
;
Cicatrix
;
Foot
;
Hand
;
Humans
;
Iron
;
Liver
;
Liver Cirrhosis
;
Liver Function Tests
;
Middle Aged
;
Porphyria Cutanea Tarda*
;
Porphyria, Acute Intermittent
;
Porphyrias*
;
Skin
;
Varicose Veins