2.Advances in epigenetic markers of dermatomyositis/polymyositis.
Yi Ying YANG ; Xiao Xia ZUO ; Hong Lin ZHU ; Si Jia LIU
Journal of Peking University(Health Sciences) 2019;51(2):374-377
Idiopathic inflammatory myopathy (IIM) is a rare group of autoimmune diseases, characterized by chronic muscle weakness, muscle fatigue and infiltration of single nuclear cells in skeletal muscle. Its subtypes include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myositis (IMNM), and the most common subtypes are DM and PM. PM is an autoimmune disease mainly manifested by muscle damage. When the skin is involved, it is called DM. The incidence of IIM was relatively low, which was 1.16-19 per million people/year, but the mortality was high and the prognosis was poor. The pathogenesis of IIM is still unclear. Previous studies suggest that both immune and non-immune mechanisms are involved in its pathogenesis, especially cellular and humoral immunity. In recent years, researchers have conducted a number of studies on the pathogenesis of IIM, especially in the study of DM/PM with the application of high-throughput biometrics. Epigenetics is a discipline that refers to the genetic phenomena of DNA methylation spectrum, chromatin structure state and gene expression spectrum transferred between cells without any changes in DNA sequence, including DNA methylation, chromatin modification and non-coding RNA changes. A large number of studies have shown that epigenetic modification plays an important role in many diseases, especially in cancer. Recent studies have also found a series of epigenetic markers related to the occurrence and development of DM/PM, mainly in the aspect of non-coding RNA changes, such as miR-10a, miR-206, etc. And there has also been some research on DNA methylation. However, no studies have been reported on whether chromatin modification is involved in the pathogenesis of DM/PM. The pathogenesis of DM/PM is complex and diverse. With the development of research, certain microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) may become biological markers for the early diagnosis of DM/PM. Therefore, this paper mainly expounds the research progress of the biomarkers of DM/PM from the aspect of epigenetics.
Biomarkers
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Dermatomyositis
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Humans
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MicroRNAs
;
Muscle, Skeletal
;
Polymyositis
3.A Case of Dern atomyositis Associated with Primary Hepatoma.
Byeong Hoon LIM ; Choong Kun HA
Journal of the Korean Neurological Association 1989;7(1):140-144
Dematomyositis is an inflammatory cutaneo-muscular disease of unknown etiology, characterized by symmetrical proximal muscle weakness and typical dermatologic manifestation. Association with systemic maligmancy has been reported in many literatures, but the relationship of dermatomyositis to internal malignancy remains controversial. In Korea, several cases of dermatomyositis or polymyositis associated with malignant neoplasm were reported. Dermatomyositis or polymyositis associated with primary hepatoma has not been reported, Recently authors experienced a patient with dermatomyositis associated with primary hepatoma, and present the case with review of literatures. This may be the first report in Korea.
Carcinoma, Hepatocellular*
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Dermatomyositis
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Humans
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Korea
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Muscle Weakness
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Polymyositis
4.The Expression of Toll-like Receptors in Idiopathic Inflammatory Myopathies.
Geun Tae KIM ; Jun Hee LEE ; Seung Hoon BAEK ; Joung Wook LEE ; Mi Ra CHO ; Ju In KIM ; Sun Hee LEE ; Dae Seong KIM ; Sung Il KIM
The Journal of the Korean Rheumatism Association 2007;14(2):118-124
Objective: To investigate the expression of toll-like receptor (TLR)-2, 4 and 9 in idiopathic inflammatory myopathies (IIMs). Methods: The expression of TLR-2, 4 and 9 was measured by real-time RT-PCR and immunohistochemical stain (IHS) from muscle tissues in patients with IIMs and controls. Results: The expression levels of TLR-2, 4 and 9 in IIMs were significantly higher than controls. TLR-2, 4 and 9 were mainly expressed on sarcolemma of muscle fibers, perimysial vascular endothelium and infiltrating inflammatory cells in dermatomyositis, whereas, they were mainly expressed on sarcolemma of muscle fibers, destructed muscle fibers, and enodmysial infiltrating inflammatory cells in polymyositis. Conclusion: TLR-2, 4 and 9 were highly expressed in muscle tissue of IIMs. These results suggest that TLR-2, 4 and 9 play a role in pathogenesis of IIMs.
Dermatomyositis
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Endothelium, Vascular
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Humans
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Myositis*
;
Polymyositis
;
Sarcolemma
;
Toll-Like Receptors*
5.The relation between chronic viral hepatitis and polymyositis.
Korean Journal of Medicine 1999;56(5):664-664
No abstract available.
Hepatitis*
;
Polymyositis*
6.A Case of a 14-Year-Old Girl Who Developed Dermatomyositis Associated with Mycoplasma pneumoniae Infection.
Hyuk Jin MOON ; Jae Kook YANG ; Dong Hyun IN ; Dong Hyun KWUN ; Hyun Ho JO ; Sung Hae CHANG
Soonchunhyang Medical Science 2015;21(2):130-133
Extrapulmonary manifestations of Mycoplasma pneumoniae infection are not uncommon and involvement of every organ system has been reported. However, association of inflammatory myositis with M. pneumoniae infection is rare. Here, we describe a patient who developed polymyositis associated with mycoplasma infection, who was treated successfully with glucocorticoid, intravenous immunoglobulin, and methotrexate.
Adolescent*
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Dermatomyositis*
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Female*
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Humans
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Immunoglobulins
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Methotrexate
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Mycoplasma Infections
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Mycoplasma pneumoniae*
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Mycoplasma*
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Myositis
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Pneumonia
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Pneumonia, Mycoplasma*
;
Polymyositis
7.Prognostic Factors Affecting Survival Rate in Inflammatory Myositis.
Hye In KIM ; Hee Kyung BAEK ; Jin Kyu JUNG ; Yong Min JO ; Sang Yeob LEE ; Sung Won LEE ; Won Tae CHUNG
The Journal of the Korean Rheumatism Association 2009;16(2):108-114
OBJECTIVE: To assess the 10-year cumulative survival outcome of polymyositis (PM) and dermatomyositis (DM) as well as the factors associated with the the outcome. METHODS: Eighty five patients with PM and twenty one patients with DM were diagnosed at our university medical center between 1997 and 2007. Thirty six patients with PM and 13 patients with DM were followed up until death or until the end of January, 2008. Gender, age, AST, ALT, CPK, LDH, ESR, CRP, aldolase, drugs of therapy, combined ILD, and cancer, and duration of remission after therapy were assessed as prognostic factors of death by the Kaplan-Meier curve and Cox regression model. RESULTS: The respective 10-year survival rate for PM and DM was 80.8% (95% confidence interval (CI): 73.3~87.2) and 55.9% (95% CI: 40.7~71.1), respectively. The median survival for PM and DM was 11.3 years (95% CI: 9.8~12.9) and 7.0 years (95% CI: 3.6~10.5), respectively. Compared to DM patients, the subjects with PM had a 167.26 fold (95% CI: 7.59~3683.19) combined ILD adjusted risk of mortality (p<0.05) and no other individual factor reached significance as a predictor of death. However, cancer had a hazard ratio (HR) of 17.00 (95% CI: 1.06~281.79) and 2.45 (95% CI: 0.78~12.45) for death in the PM and DM group, respectively. CONCLUSION: According to an analysis of the survival and its prognostic factors in patients with PM and DM, ILD is a risk factor for mortality in PM and cancer was risk factor for mortality in both PM and DM.
Academic Medical Centers
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Dermatomyositis
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Fructose-Bisphosphate Aldolase
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Humans
;
Myositis
;
Polymyositis
;
Risk Factors
;
Survival Rate
8.A Case of Dermatomyositis That Developed after Repeated Filler Material Injections for Cosmetic Purposes.
Myung Won LEE ; So Youn YOUN ; So Ra KANG ; Jisoo LEE
The Journal of the Korean Rheumatism Association 2010;17(1):46-50
Dermatomyositis and polymyositis are uncommon, acquired idiopathic inflammatory myopathies of an unknown etiology. Although there are 9 reported cases in the literature of developing dermatomyositis or polymyositis after collagen dermal injection, it is still controversial whether there is a link between injectable filler materials and autoimmune diseases, and specifically dermatomyositis/polymyositis. We experienced a case of a 40-year-old woman who developed dermatomyositis after repeated injections of multiple filler materials, including collagen for cosmetic purposes, which suggests a temporal relation between the two factors. The benefit-to-risk ratio should be assessed for repeated cosmetic surgical procedures that use filler materials.
Adult
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Aluminum Hydroxide
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Autoimmune Diseases
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Carbonates
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Collagen
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Cosmetics
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Dermatomyositis
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Female
;
Humans
;
Myositis
;
Polymyositis
9.Systemic lupus erythematosus accompanied with idiopathic inflammatory myopathy: report of 2 cases.
Young Ah PARK ; Seung Ho SONG ; Dong Woo KIM ; Jung Hyuk KIM ; Hyun Kyu CHANG ; Jee Young LEE ; Na Hye MYONG
Korean Journal of Medicine 2003;65(5):604-609
Generalized myalgia and muscle tenderness are relatively common during exacerbations in patients with systemic lupus erythematosus (lupus), and inflammatory myositis involving the proximal muscles occurs in 5~11% of patients during the course of the disease. However, patients with overlap syndrome of lupus and idiopathic inflammatory myopathy have been not that frequent. We described 2 patients with overlap syndrome of these two diseases. Patient 1 was a 27-year-old female patient concurrently having lupus and dermatomyositis. She manifested the characteristic skin rash for dermatomyositis such as heliotrope rash. Patient 2 was a 32-year-old female patient concurrently having lupus and polymyositis, in whom the disease-specific autoantibodies for lupus or idiopathic inflammatory myopathy such as anti-ds DNA antibody, anti-Sm antibody and anti-Jo-1 antibody were positive.
Adult
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Autoantibodies
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Dermatomyositis
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DNA
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Exanthema
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Female
;
Humans
;
Lupus Erythematosus, Systemic*
;
Muscles
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Myalgia
;
Myositis*
;
Polymyositis
10.Clinical Implication of Magnetic Resonance Imaging in the Idiopathic Inflammatory Myopathies.
Jae Hyun KOH ; Suk Joo HONG ; Hong Joon AHN ; Joong Kyung AHN ; Chan Hong JEON ; Hoon Suk CHA ; Joong Mo AHN ; Hyun Sook KIM ; Yeon Lim SEO ; Eun Mi KOH
The Journal of the Korean Rheumatism Association 2002;9(3):159-168
OBJECTIVE: The purpose of the study is to describe the magnetic resonance imaging (MRI) findings and to investigate useful sequences of MRI in inflammatory myopathies. A third goal is to correlate MRI findings with the grade of histopathologic severity. METHODS: Sixteen patients (13 women, 3 men), aged 21-74 years (median age of 49) with inflammatory myositis (examined with both MRI and muscle biopsy) were studied. Ten patients were diagnosed with polymyositis and 6 with dermatomyositis. Conventional T1-weighted (SE 366/12) and T2-weighted (SE 4766/90) fast spin-echo and fat-suppressed T1-weighted MR images with contrast enhancement (FSAT T1 CE) were obtained. Ratios between the signal intensities of a muscle and the signal intensities of subcutaneous fat in the same tomographic sections were calculated to objectively represent the degree of signal intensities. Semi-quantitative grading of severities in muscle biopsy specimen was examined based on invasion of inflammatory cells and necrosis, degeneration and regeneration of muscle fiber by a neuromuscular pathologist. RESULTS: FSAT T1 CE could objectively describe the severity of involvement in inflammatory myopathies. The quadriceps muscle group, especially the vastus muscle tended to be most severely and frequently involved in inflammatory myositis with FSAT T1 CE (statistically insignificant). The vastus intermedius muscle was more severely involved in dermatomyositis than polymyositis. The signal intensity of abnormal muscle sampled by biopsy correlated positively with the grade of muscle biopsy. CONCLUSION: MRI shows promise in identifying pathologic muscle in patients suspected of having one of the inflammatory myopathies. The degree of signal intensity on MRI may reflect the severity of grade in muscle biopsy.
Biopsy
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Dermatomyositis
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Female
;
Humans
;
Magnetic Resonance Imaging*
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Myositis*
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Necrosis
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Polymyositis
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Quadriceps Muscle
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Regeneration
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Subcutaneous Fat