1.Genetic polymorphisms of the FcgammaR genes in periodontally healthy Korean population.
Seung Yun SHIN ; Kyoung Hwa KIM ; Ok Jin PARK ; Kak Kyun KIM ; Chong Pyoung CHUNG ; Hiromasa YOSHIE ; Young KU
The Journal of the Korean Academy of Periodontology 2003;33(4):747-753
No abstract available.
Polymorphism, Genetic*
2.Genetic polymorphisms of the IL-1betagenes in periodontally healthy Korean population.
Seung Yun SHIN ; Kyoung Hwa KIM ; Ok Jin PARK ; Kak Kyun KIM ; Young KU ; Hiromasa YOSHIE ; Chong Pyoung CHUNG
The Journal of the Korean Academy of Periodontology 2003;33(4):739-745
No abstract available.
Polymorphism, Genetic*
3.Glutathione S-Transferase: An Overview on Distribution of GSTM1 and GSTT1 Polymorphisms in Malaysian and Other Populations
Malaysian Journal of Medicine and Health Sciences 2019;15(SP2):85-95
Glutathione s-transferases (GSTs) are the vital enzymes involved in Phase II metabolism to detoxify a wide range of carcinogenic metabolites in the body. GST class mu-1 (GSTM1) and GST class theta-1 (GSTT1) are the genes encoding for the GST isoenzymes. Nevertheless, both genes were frequently reported absent (null) in most of the populations at different frequencies. Null polymorphism will affect the production of GSTs and impair the ability to eliminate carcinogenic compounds which had been shown to expose null individuals to high risk of several cancers such as gastric and lung cancer. Thus, this review will briefly summarize on the GSTM1 and GSTT1 polymorphisms, frequencies of null variants in populations worldwide, including Malaysian, and their relevancy to the underlying basis of toxicological response to xenobiotics. Additionally, the genotyping assays used in GST studies will also be discussed.
Genetic polymorphism
4.Fc gammaR genetic polymorphisms of periodontal disease in Korean population.
Seung Yun SHIN ; Kyoung Hwa KIM ; Ok Jin PARK ; Yong Moo LEE ; In Chul RHYU ; Kack Kyun KIM ; Young KU ; Hiromasa YOSHIE ; Soo Boo HAN ; Chong Pyoung CHUNG
The Journal of the Korean Academy of Periodontology 2004;34(3):671-681
No abstract available.
Periodontal Diseases*
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Polymorphism, Genetic*
5.Genetic polymorphism of parotid isoelectric focusing variant protein(PIF) in a Korean population.
Korean Journal of Legal Medicine 1993;17(2):34-43
No abstract available.
Isoelectric Focusing*
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Polymorphism, Genetic*
6.Genetic polymorphisms in NAT1, NAT2, GSTM1, GSTP1 and GSTT1 and susceptibility to colorectal cancer among Filipinos
Eva Maria C. Cutiongco-de la Paz ; Corazon A. Ngelangel ; Virgilio P. Bañ ; ez ; Francisco T. Roxas ; Catherine Lynn T. Silao ; Jose B. Nevado Jr. ; Alberto B. Roxas ; Oliver G. , Florendo ; Ma. Cecilia M. Sison ; Orlino Bisquera, Jr ; Luminardo M. Ramos ; Elizabeth A. Nuqui ; Arnold Joseph M. Fernandez ; Maria Constancia O. Carrillo ; Beatriz J. Tiangco ; Aileen D. Wang ; Rosalyn H. Sebastian ; Richmond B. Ceniza ; Leander Linus Philip P. Simpao ; Lakan U. Beratio ; Eleanor A. Dominguez ; Albert B. Albay Jr. ; Alfredo Y. Pontejos Jr. ; Nathaniel W. Yang ; Arsenio A. Cabungcal ; Rey A. Desales ; Nelia S. Tan-Liu ; Sullian S. Naval ; Roberto M. Montevirge ; Catalina de Siena E. Gonda-Dimayacyac ; Pedrito Y. Tagayuna ; John A. Coloma ; Gil M. Vicente ; Higinio T. Mappala ; Alex C. Tapia ; Emmanuel F. Montana Jr. ; Jonathan M. Asprer ; Reynaldo O. Joson ; Sergio P. Paguio ; Tristan T. Chipongian ; Joselito F. David ; Florentino C. Doble ; Maria Noemi G. Pato ; Benito B. Bionat Jr ; Hans Francis D. Ferraris ; Adonis A. Guancia ; Eriberto R. Layda ; Andrew D. Dimacali ; Conrado C. Cajucom ; Richard C. Tia ; Mark U. Javelosa ; Regie Lyn P. Santos-Cortez ; Frances Maureen C. Rocamora ; Roemel Jeusep Bueno ; Carmencita D. Padilla
Acta Medica Philippina 2017;51(3):216-222
Objectives. Polymorphisms in metabolic genes which alter rates of bioactivation and detoxification have been shown to modulate susceptibility to colorectal cancer. This study sought to evaluate the colorectal cancer risk from environmental factors and to do polymorphism studies on genes that code for Phase I and II xenobiotic metabolic enzymes among Filipino colorectal cancer patients and matched controls. Methods. A total of 224 colorectal cancer cases and 276 controls from the Filipino population were genotyped for selected polymorphisms in GSTM1, GSTP1, GSTT1, NAT1 and NAT2. Medical and diet histories, occupational exposure and demographic data were also collected for all subject participants.Results. Univariate logistic regression of non-genetic factors identified exposure to UV (sunlight) (OR 1.99, 95% CI: 1.16-3.39) and wood dust (OR 2.66, 95% CI: 1.21-5.83) and moldy food exposure (OR 1.61, 95% CI:1.11-2.35) as risk factors; while the NAT2*6B allele (recessive model OR 1.51, 95% CI :1.06-2.16; dominant model OR 1.87, 95% CI: 1.05-3.33) and homozygous genotype (OR 2.19, 95% CI: 1.19-4.03) were found to be significant among the genetic factors. After multivariate logistic regression of both environmental and genetic factors, only UV radiation exposure (OR 2.08, 95% CI: 1.21-3.58) and wood dust exposure (OR 2.08, 95% CI: 0.95-5.30) remained to be significantly associated with increasing colorectal cancer risk in the study population.Conclusion. This study demonstrated that UV sunlight and wood dust exposure play a greater role in influencing colorectal cancer susceptibility than genotype status from genetic polymorphisms of the GST and the NAT` genes.
Colorectal Neoplasms
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Polymorphism, Genetic
7.CD14/-159 and TNFα/-308 promoter polymorphisms are not associated with Development of Idiopathic Neonatal Hepatitis among Filipinos
Florence Giannina F. San Jua ; Annavi Marie G. Villanueva ; Germana Emerita V. Gregorio ; Catherine Lynn T. Silao
Acta Medica Philippina 2017;51(3):233-238
Objective:
To determine if the CD14/-159 and the TNFα/-308 single nucleotide polymorphisms (SNPs) are associated with the development of Idiopathic Neonatal Hepatitis (INH) in Filipino children.
Methods:
Genomic DNA from 33 patients diagnosed with INH and 33 age- and sex-matched controls, children without any liver disease, were recruited. Baseline serum total bilirubin (TB), direct bilirubin (DB), and alkaline phosphatase (ALP) of the patients were obtained from their medical records. Genotypes for CD14/159 and TNFα/-308 were determined via PCR and direct sequencing.
Results:
No significant difference was seen between the frequency of the CD14/-159 T allele (p=0.86) nor the TNFα/-308 A allele (p=0.62) between INH patients and controls. There was also no significant difference between the genotypic distribution of the INH and control populations for both CD14/-159 (p=0.54) and TNFα/-308 (p=0.62). There were also no significant differences noted between the different genotypes of CD14/159 and TNFα/-308 and levels of alkaline phosphatase (p=0.65, p=0.91), total bilirubin (p=0.89, p=0.75), and direct bilirubin (p=0.93, p=0.68).
Conclusion
In this preliminary study, CD14/-159 and TNFα/-308 showed no association with the development of INH among Filipinos.
Polymorphism, Genetic
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Neonatal hemochromatosis
8.Analysis of genetic diversity and genetic relationships of Lonicera macranthoides cultivars.
Daxia CHEN ; Xue ZHANG ; Longyun LI
China Journal of Chinese Materia Medica 2012;37(13):1912-1916
OBJECTIVETo study genetic diversity and genetic relationships among Lonicera macranthoides cultivars.
METHODFive cultivars were estimated by ISSR and SRAP. The data of amplified bands were analyzed by Treeconw software. The system diagram of genetic relationship was built by UPGMA.
RESULTTwenty ISSR primers amplified 186 bands with 103 (54.63%) polymorphic bands and 58 SRAP primer combinations amplified 591 bands with 347(55.46%) polymorphic bands. Genetic distance ranges were 0.058 4-0.230 8 (by ISSRs) and 0.1071-0.2611 (by SRAPs). Both ISSR and SRAP analyses revealed a middle level of genetic diversity in L. macranthoides cultivars. The dendrograms based on SRAP and ISSR markers were not all the same.
CONCLUSIONThe genetic diversity of L. macranthoides cultivars is middle. ISSR and SRAP markers can be effectively applied to genetic analysis in L. macranthoides cultivars.
Genetic Variation ; Lonicera ; genetics ; Polymorphism, Genetic ; Software
9.Regional Difference of Genetic Polymorphism in Korea for Determination of Subpopulation.
Soong Deok LEE ; Jung Bin LEE ; Yoon Seong LEE
Korean Journal of Legal Medicine 1998;22(1):19-26
To confirm whether there exist the subpopulation in Korea, the genetic profiles for the residents in three representative regions, Cheju-island, Cheonla-do, Gyeongsang-do were compared. VNTR D1S80 loci, STR vwF loci and MBP loci were studied, and distribution and frequency of each allele, observed and expected heterozygosity, observed number of alleles and genotypes were compared for the above three and artificially amalgamated group. The number of alleles was smaller in some loci, but this was thought to be due to the different sample number. The difference between observed and expected heterozygosity was also insignificant. From these it seemed that the subpopulation did not exist in Korea.
Alleles
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Genotype
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Korea*
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Polymorphism, Genetic*
10.Polymorphism of Black Snake Venom RNase.I - Two distinct kinetical forms
Pharmaceutical Journal 2003;0(6):167-170
In the study, using the kinetic method for the examination of the dependence between the specific activity of the enzyme and the concentration of the enzyme itself in the combined reaction, the researchers have proved that the Ribonuclease (R.Nase) molecule of the black cobra (Naja naja) venom exits at least in two interconvertible forms with the difference in specific activity of almost one grade. These two forms are probably the different oligomers or configurations, temporarily named as the kinetic forms of R.Nase found in the black cobra venom.
Snake Venoms
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Ribonucleases
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Polymorphism, Genetic