1.Adjuvant Treatment with Chemotherapeutic Agents and Polyadenylic-Polyuridylic Acid in Operable Stomach Cancers: I. Enhancement of Natural Killer Cell Activity.
Jung Koo YOUN ; Byung Soo KIM ; Jin Sik MIN ; Heung Jai CHOI ; Yoo Bock LEE ; Dong Woo LEE ; Eun Hee KOH ; Kyung Won KIM ; Kyi Beom LEE ; Michael MICHELSON
Yonsei Medical Journal 1985;26(1):1-7
Natural Killer (NK) cell activity of 47 operable stomach cancer patients was sequentially studied before and after chemotherapy in association with polyadenylic. polyuridylic acid [poly(A).poly(U)]. NK activity was determined by an in vitro 4 h chromium release assay using nonadherent mononuclear cells isolated from peripheral bloods as effectors and human myeloblastic cells (K562) as targets. The following results were obtained: 1) The mean NK activity of the 47 patients tested before chemotherapy was significantly lower than that of 14 healthy controls. 2) The patents who received chemotherapy consisting of 5 FU (12 mg/kg) and adriamycin (40 mg/M2) showed an increase in NK activity 5 days after injection as compared to that of the same patients tested before chemotherapy. 3) In these patients, an additional administration of poly(A) poly(U) (100mg) resulted in a further significant increase of NK activity 2 days later, whereas the control patients who received placebo showed no change of NK activity.
Adult
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Aged
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Combined Modality Therapy
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Doxorubicin/therapeutic use
;
Female
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Fluorouracil/therapeutic use
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Human
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Killer Cells, Natural/drug effects*
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Male
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Middle Age
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Poly A-U/pharmacology
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Poly A-U/therapeutic use*
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Stimulation, Chemical
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Stomach Neoplasms/drug therapy*
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Stomach Neoplasms/surgery