1.The clinical value of China Savin pollen extract used for skin prick test.
Kai GUAN ; J X ZHOU ; R Q WANG ; J YIN ; L L WANG ; Y X ZHI ; J L SUN ; H LI ; L P WEN ; J Q GU ; R TANG ; Z X WANG ; L S LI ; T XU
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2018;32(3):161-166
The aim of this study is to evaluate the effectiveness and safety of China Savin pollen extract which was used for skin prick test (SPT) in the diagnosis of China Savin pollen allergy. Patients with diagnosis of allergic diseases were collected from Allergy Department of Peking Union Medical College Hospital. All patients were given SPT with China Savin pollen extract, and the mean wheal diameter (MWD) was measured after 15 minutes. Receiver operating characteristic curve (ROC) analysis was performed based on the results of serum specific immunoglobulin E (sIgE). The effectiveness of SPT in the diagnosis of China Savin pollen allergy was evaluated under different diagnostic cutoff values. Adverse events were also recorded to evaluate the safety. A total of 1 029 patients were enrolled in this study without drop out case. There were 1 007 patients in full analysis set (FAS) and 765 patients in per protocol analysis set (PPS). The elimination rate was 25.66%. The area under the ROC curve of FAS is 0.814 (95%: 0.788-0.839); which of PPS is 0.829 (95%: 0.801-0.857). Based on the ROC curve of PPS, the optimal and the 95% specificity diagnostic cutoff values of MWD were 3.25 mm and 4.75 mm respectively. Based on different diagnostic cutoff value (3.00, 3.25 and 4.75 mm), the sensitivities of SPT with China Savin pollen extract were 0.740 0 (95%: 0.701 6-0.778 4), 0.700 (95%: 0.659 8-0.740 2) and 0.532 (95%: 0.488 3-0.575 7) respectively, whereas the specificity was gradually increased in sequence, which was 0.769 8 (95%: 0.719 1-0.820 5), 0.826 4 (95%: 0.780 8-0.872 0) and 0.950 9 (95%: 0.924 9-0.976 9) respectively. There were 7 adverse events observed among 6 patients (rate: 0.583%, 6/1 029). The manifestation was mild. There was no severe adverse event. SPT with China Savin pollen extract is an effective and safe tool for the diagnosis of China Savin pollen allergy. The effectiveness of diagnosis could be improved based on integration of medical history and different diagnostic threshold values of SPT.
Allergens
;
adverse effects
;
China
;
Humans
;
Immunoglobulin E
;
Pollen
;
adverse effects
;
Rhinitis, Allergic, Seasonal
;
diagnosis
;
Skin Tests
2.A Study of Allergy Skin Tests with Korean Pollen Extracts.
Yoo Lee KIM ; Soo Kon LEE ; Seung Heon OH ; Byung Soo MOON ; Hae Sim PARK ; Chein Soo HONG
Yonsei Medical Journal 1987;28(2):112-118
In Korea, there are two descrite pollen seasons: a tree pollen season and a weed pollen season. In order to investigate the incidence of sensitization to the major pollens and to evaluate is clinical significance in respriatory allergic disease, skin prick tests were performed using 7 species of Korean pollen extracts (K-P extracts) and specific IgE was measured by the Phadebas radioallergosorbent test (RAST) in patients with positive skin prick tests. Of the 317 patients with respiratory allergic diseases 73 patients (23.0%) were skin prick test positive to one or more K-P extracts and the positive reactions to individual pollens were as follows: 14.2% (45/317) positive to sagebrush 10.4% to ragweed, 5.0% to grass, 4.1% to oak, 3.8% to alder, 1.9% to poplar; and 0% to pine. The 30-39yr old group manifested the highest skin test positivity 36.7%. There was no difference in the skin reactivity according to the patient's sex and the kinds of allergic disease. Also there was no relationship between birth season and skin test positivity. The agreement between the results of the skin prick test with K-P and commercially prepared Bencard's pollen extracts (B-P extracts) was good. There were good correlations between the strongly positive skin prick test and a posivite RAST and also between a netative skin prick test and a negative RAST. From this study, it can be concluded that overall sensitization rate of respiratory allergy patients to K-P exstracts was 23.0%, and that weed pollens such as sagebrush and ragweed were major pollens.
Female
;
Human
;
Korea
;
Male
;
Pollen/adverse effects*
;
Radioallergosorbent Test
;
Respiratory Hypersensitivity/diagnosis
;
Respiratory Hypersensitivity/epidemiology*
;
Skin Tests
4.A study on pollen allergens in China.
Zhi-Gang LIU ; Juan-Juan SONG ; Xiao-Li KONG
Biomedical and Environmental Sciences 2010;23(4):319-322
Allergic disease caused by airborne pollen is a major health problem in China. Intensive study on pollen allergens can be of great help for preventing and treating pollinosis. Four aspects of the study on pollen allergens in China including major allergic pollen in our country, analysis and purification of pollen allergen composition, recombinant pollen allergens and clinical application of pollen allergens are described in this paper.
Air Pollutants
;
adverse effects
;
Allergens
;
administration & dosage
;
immunology
;
China
;
epidemiology
;
Desensitization, Immunologic
;
methods
;
Humans
;
Pollen
;
immunology
;
Recombinant Proteins
;
administration & dosage
;
immunology
;
Rhinitis, Allergic, Seasonal
;
epidemiology
;
etiology
;
prevention & control
;
Seasons