No abstract available.
Breast Neoplasms* ; Breast* ; DNA* ; Oncogene Proteins* ; Oncogenes* ; Ploidies* ; Prognosis*

A syringomatous adenoma of the nipple is a benign locally infiltrating neoplasm histologically similar to the syringoma of the skin. Morphologically similar lesions have been described as adenoma of the nipple or florid papillomatosis. Patient was a 33 year old woman who was admitted with a history of bloody nipple discharge from her right breast. With a clinical impression of Paget's disease explorative mastectomy was performed. Microscopically typical tubular and duct like structures with syringomatoid features were present throughout the stroma of the nipple.
Adenoma/*pathology ; Adult ; Breast Neoplasms/*pathology ; Female ; Humans ; Nipples

No abstract available.
Cell Line*

Sweet's syndrome is an uncommon reactive dermatosis characterized by fever, polymorphonuclear leukocytosis, painful erythematous cutaneous plaques and dense dermal infiltrate of neutrophils at the skin lesions. Unlike Sweet's syndrome associated with patients with malignancies, autoimmune diseases, antecedent infectons-most commonly the upper respiratory infections, it is reported to be rarely associated with systemic lupus erythematosus (SLE). Here we report a rare case of young female with Sweet's syndrome and SLE presenting with high fever.
Autoimmune Diseases ; Female ; Fever ; Humans ; Leukocytosis ; Lupus Erythematosus, Systemic* ; Neutrophils ; Respiratory Tract Infections ; Skin ; Skin Diseases ; Sweet Syndrome*

The age of onset of Korean breast carcinoma is younger than that in western countries by some 10 years, thus the criteria of young age in manuscript from western countries cannot reflect the characteristics of young breast cancer properly in Korea. We studied 290 breast cancer patients, 35 years old or younger retrospectively. Jan. 1980 to Dec. 1995 in the Department of Surgery, Seoul National University Hospital. The age criteria of 30 and 35 years was utilized to define two groups. The group (age< or = 35) had larger primary tumors, more metastatic lymph nodes, and worse stages than older counterpart (p=0.015, 0.0066, 0.0329 respectively). They had worse disease-free survival but not overall survival (p=0.2427, 0.0312 respectively). The other group (age< or = 30) showed significantiy worse outcome in overall as well as disease free survival (p=0.0056, 0.0013) compared to the group (age>30). When we compared the group of age< or = 30 to that of 31< or = age< or = 35, there was statistically significant difference in primary tumor size, axillary nodal status and pathological stage (p=0.023, 0.019, 0.022 respectively). The age of 30 might be better criteria to define young age as prognostic factor rather than age of 35 in Korea.
Adult* ; Age of Onset ; Breast Neoplasms* ; Breast* ; Disease-Free Survival ; Humans ; Korea ; Lymph Nodes ; Prognosis ; Retrospective Studies ; Seoul

PURPOSE: The age of onset of Korean breast carcinoma is younger than that in western countries by some 10 years, thus the criteria of young age in manuscript from western countries cannot reflect the characteristics of young breast cancer properly in Korea. MATERIALS AND METHODS: We studied 290 breast cancer patients, 35 years old or younger retrospectively, from Jan. 1980 to Dec. 1995 in the Department of Surgery, Seoul National University Hospital. The age criteria of 30 and 35 years was utilized to define two groups. RESULTS: The group(age< or =35) had larger primary tumors, more metastatic lymph nodes, and worse stages than older counterpart(p=0.015, 0.0066, 0.0329 respectively). They had worse disease-free survival but not overall survival(p=0.0312, 0.2427 respectively). The other group(age < or =30) showed significantly worse outcome in overall as well as disease free survival(p=0.0056, 0.0013) compared to the group(age>30). When we compared the group of age< or =30 to that of 31< or = age < or =35, there was statistically significant difference in primary tumor size, axillary nodal status and pathological stage(p=0.023, 0.019, 0.022 respectively). CONCLUSION: The age of 30 might be better criteria to define young age as prognostic factor rather than age of 35 in Korea.
Adult* ; Age of Onset ; Breast Neoplasms* ; Breast* ; Disease-Free Survival ; Humans ; Korea ; Lymph Nodes ; Prognosis ; Retrospective Studies ; Seoul

PURPOSE: We have conducted this study to investigate the role of c-myc and AAT in gastric carcinoma progression and to see if clinical application of its expression in cancer tissue is of help for the diagnosis or in determining prognosis of gastric carcinoma. MATERIALS AND METHOD: The expression of c-Myc and AAT by immunohistochemical method applied to paraffin-embedded tissue sections of endoscopic biopsy materials of 71 cases of gastric carcinoma (24 early and 47 advanced) and immunoreactivities of antigens were correlated with histological differentiation of carcinoma, degree of tumor infiltration of mononuclear cells, serum levels of carcinoembryonic antigen (CEA) and presence of distant metastases. RESULTS: c-Myc in gastric carcinoma tissue was expressed in 24 cases (33.8%), and the rate of immunoreactivity of c-Myc was higher in the advanced carcinoma cases (38.2%) than early carcinoma cases (25.0%), but the difference was not stastistically significant. The elevated c-Myc expression correlated well with the elevation of serum CEA levels (P<0.05), with the presence of distant metastses (p<0.05), especially with peritoneal metastsis (p<0.05). AAT expression in gastric carcinoma was shown in 11 cases (14.1%), and the rate of immunoreactivity of AAT was significantly higher in advanced carcinoma cases (21.3%) than early carcinoma cases (4.2%) (p<0.05). The elevated expression of AAT correlated well with the elevation of serum CEA levels (p<0.05), and showed negative correlation with the degree of mononuclear cell infiltration in tumor area (p<0.05). The increased expression of c-Myc and AAT in gastric carcinoma correlated well (p=0.05, k= 0.31), which suggests the cooperative action of the two in gastric carcinoma progression. CONCLUSIONS: Our findings suggest that c-Myc expression may be a good marker of high grade malignancy in gastric carcinoma, and may be able to be used clinically in predicting distant metastases, especially for peritoneal dissemination. Our data also imply that c-myc, through its proliferative action, may play an important role in the progression of gastric carcinoma in cooperation with AAT which has immunosuppresive action.
Biopsy ; Carcinoembryonic Antigen ; Diagnosis ; Neoplasm Metastasis ; Prognosis

BACKGROUND: To meet the need for a subspecialized skin type system, the Baumann skin type (BST) system was proposed. OBJECTIVE: To evaluate the distribution of BST types and influencing factors among Korean women. METHODS: BST questionnaires were administered to 1,000 Korean women. The possible responses were as follows: oily (O) or dry (D), sensitive (S) or resistant (R), pigmented (P) or non-pigmented (N), and wrinkled (W) or tight (T). The correlations of the BST with the subjects' age, location, ultraviolet (UV) ray exposure, drinking and smoking habits, and blood type were assessed. RESULTS: The OSNT, DSNT, DRNT, and OSNW skin types were the most common skin types (55.3%). The O, S, P, and W types accounted for 46.6%, 68.8%, 23.2%, and 31.9%, respectively. The proportion of the O and S type was the highest in Gyeongsangbuk-do (55.0%) and Seoul (77.2%). The proportion of the P and W type was the highest in Gyeongsangbuk-do (33.0%) and Chungcheong-do (39.0%). The O type decreased in the higher age group, whereas the P and W type showed a reversed tendency. In smokers, the proportion of W type was significantly higher than in the non-smokers (66.3% vs. 24.1%, p<0.05). CONCLUSION: The 4 most common BST types were OSNT, DSNT, DRNT, and OSNW. In the comparison across the 4 BST parameters according to the age, region, smoking and drinking habits, occupation, blood type, and UV exposure, significant differences were observed. Individualized and customized skin care is required according to the personal skin type.
Drinking ; Female* ; Gyeongsangbuk-do ; Humans ; Occupations ; Seoul ; Skin Care ; Skin* ; Smoke ; Smoking ; Surveys and Questionnaires

Pyoderma gangrenosum (PG) is a vasculitic process, often associated with systemic diseases, including Takayasu's arteritis (TA), rheumatoid arthritis, and inflammatory bowel disease. Most cases of PG associated with TA have been observed in Japan. However, this association is not commonly observed in North American and European patients. PG is often refractory to therapy, requiring high dosages of glucocorticoids. Here, we describe a case of recalcitrant PG that was associated with TA and successfully treated with methotrexate.
Arthritis, Rheumatoid ; Glucocorticoids ; Humans ; Inflammatory Bowel Diseases ; Japan ; Methotrexate* ; Pyoderma Gangrenosum* ; Pyoderma* ; Takayasu Arteritis*

This article presents the results of the Implementation Study of the Seoul Cancer Registry, which started in July, 1991 as a population based cancer registry in Seoul, Korea. The completeness and validity of the registered data were evaluated using Mortality/Incidence ratio (M/I ratio), Histologically Verified Cases (HV%), Primary Site Uncertain (PSU%), and Age Unknown (Age UNK%). Owing to the additional active surveillance, the completeness of the data turned out to be fairly acceptable, except for the aged over 75(Mortality/Incidence ratio was over 100%). Eventhough the Seoul cancer registry(SCR) has further way to go in the completeness especially among elderly persons, the validity of SCR data was also acceptable in terms of HV%, PSU%, and Age UNK%. However, PSU% and Age UNK% might need to be further reduced to be comparable with other well established cancer registries. The age standardized incidence rates(ASR) of all cancers between July 1, 1991 and June 30, 1992 were 232.4/100,000 in males and 147.9/100,000 in females. The top five major sites of cancers in Seoul were the stomach, liver, lung, colo-rectum, and bladder in order in males, and the uterine cervix, stomach, breast, colo-rectum, and liver in females. Those 5 cancer sites comprised 68.9% and 64.7% of the total cancer incidence in males and females, respectively.
Adolescent ; Adult ; Age Factors ; Aged ; Child ; Child, Preschool ; Female ; Human ; Incidence ; Infant ; Korea/epidemiology ; Male ; Middle Age ; Neoplasms/*epidemiology/pathology ; *Registries ; Sex Factors ; Support, Non-U.S. Gov't