Beta-fluoroethylacetate has been extensively used as the rodenticide in Korea. In some patients with acute poisoning, beta-fluoroethylacetate caused cerebellar dysfunction as a single and persistent neurologic sequela after a period of an acute neurological disorder which is characterized by mental deterioration, seizures, and respiratory failure. But there has been no report of pathological findings to explain neurological deficit. We tried to verify the histologic changes of the central nervous systems in beta-fluoroethylacetate poisoned rats. Silver staining(Gallyas) was used to evaluate the histology. In acute intoxication experiment with LD50(7mg/Kg), beta-fluoroethylacetate elicited acute onset of consciousness deterioration, generalized tonic-clonic seizures and large amplitude tremulous activity involving whole body with full recovery after 24 hours. There was no discernible pathologic change in CNS in acutely poisoned rats. However, when poisoned with sublethal dose(5mg/Kg) daily for five days, a moderate degree of nerve cell degeneration was found selectively in dentate nucleus, Purkinie cell layer, vestibulo-cochlear nucleus and striatum. This change was not seen in hippocampus, cerebral cortex or cerebellar cortex. These findings were well correlated with the previous reports of selective pathology in human 5-FU intoxication cases. Our preliminary results suggest that beta-fluoroethylacetate, a kind of cellular metabolism inhibitor may induce selective neuropathology mainly involving cerebellar output pathway in rats.
Humans ; Rats ; Animals ; Poisons

By synthesizing and analysing poisoning analyses from 1996 to 2000 at Hai Phong Viet Tiep Hospital found an increasing incidence of insecticide and raticide poisons. Incidence of insecticide and raticide was 21.18% in 1996, in which raticide rate was 5.08%, raticide rate was 20.11% in 2000, there were a noticeable rate of raticide poisons without knowing the origin of the raticide in chinese (called chinese raticide). The poisoning analyses played a considerable role in giving first aid for poisons in general and for insecticide and raticide poisons in particilar
Insecticides ; Poisons ; Epidemiology

There was no acute toxic on rabbit's bodies after ingested activated charcoal suspension (1g/kg and 1,2g/kg body weight). Circulating blood cells and the function of kidney and liver were not changed after 7 days ingested activated charcoals
Animal Experimentation ; Poisoning ; Poisons

From 1997 to 2000, 22 children aged 5-15 (11 boys, 11 girls) were admitted in emergency department of Pediatric Institute due to intoxincation of Moc dieu. Only 9/17 (52.9%) of subjects described exactly the toxic plant. The most significant clinical signs are vomit and fatigue (100%), jaundice (100%). Hemorrhage of various degree around the orbit (17/17) and the sclera, 15/17 cases of edema and aliogourine. This is a life threatening intoxication in mild and mode rate cases, the prognos is of treatment at the institute is good, only 1 death
Child ; Poisoning ; Poisons

Naturenz, a mixture of plant oxydase, protease, natural anti-oxydants, aminoacids and vitamins has been used for treating dioxin exposed patients. This preparation can improve the patients status. An icrease of SH-group, of total hem content and of anilin hydroxylase acitivty in blood, a decreasing of urine urobilinogen was notified on patients after administration
Dioxins ; Chemistry ; Poisons

Calibration ; Humans ; Poisons ; urine

The exact of Zingiber officinale Rosc (ZO) and ZO-Typhonium divaricatum Decne (TD) complex were used to evaluate its antiemetic effect and acute toxicity on young dogs and mice. The results showed that the extract of ZO in dose of 0.1 g/kg body weigh, ZO 0.1 g and TD 0.12 g complex/kg body weigh per oral route have antiemetic effect in comparison with control one. Both of raw and pure TD extracts have equal effect. ZO and TD have a quite low acute toxicity
Animal Experimentation ; Poisons ; Pharmaceutical Preparations

Herbicides ; poisoning ; Humans ; Occupational Exposure ; Poisons

OBJECTIVES: To retrospectively analyze homicide cases of death after injection and provide reference for forensic identification. METHODS: Six homicide cases of death after injection which were investigated by the Criminal Investigation Team of Shanghai Public Security Bureau were collected and analyzed, including case situation, scene investigation, autopsy and other materials. RESULTS: The 6 cases were premeditated crimes, 5 cases took place in private spaces, and 5 cases involved the victims approached by suspects' decoy. There were no obvious abnormalities at the scene of the 6 cases. In 6 cases, the victim's body surface injury was mild or no, lividity color was abnormal, and the needlestick injury showed different manifestations from conventional medical measures. CONCLUSIONS Death after injection is a highly concealed crime and easy to be ignored. For the suspected injection injury found in autopsy, it is necessary to carefully examine, identify and analyze, be alert to the situation of injecting poison (drug) and do a good job in evidence fixation and material extraction.
Autopsy ; China/epidemiology* ; Homicide ; Poisons ; Retrospective Studies

PURPOSE: The purpose of this study was to examine the research characteristics and the trend of the Journal of the Korean Society of Clinical Toxicology by bibliometric analysis. METHODS: This study was a retrospective quantitative literature review of the publications. We collected data from the internet homepage of the Korean Society of Clinical Toxicology. Among 228 publications, a total of 225 articles were included in this analysis. The data were analyzed from different perspectives, including article types, study design, number of authors, type of toxic material, and the top five ranking prolific authors and the affiliated organization were identified. RESULTS: A total of 225 articles were analyzed; 98(43.6%) were original articles, 115(51.1%) were case reports, and 12(5.3%) were reviews. Among the original articles, nine were prospective studies and 89 were retrospective studies, which were assorted according to study design; there were two(2.0%) cross sectional studies, 93(94.9%) cohort studies, and three(3.1%) etc. The median number of authors per article was five and the top five ranking authors and affiliated organizations published 31.1% and 32.8% of total articles, respectively. The most abundant topic was pesticides, followed by natural poisons and poisons encountered in the work place. CONCLUSION: Since its foundation, the Journal of the Korean Society of Clinical Toxicology has published 19 issues and 228 articles and has played a key role in development of toxicology research in Korea. However, low ratio of original articles and a decrease in the number of recent articles indicates that greater effort is needed in clinical research. In addition, further interest of many experts and various institutions is necessary.
Bibliometrics* ; Cohort Studies ; Cross-Sectional Studies ; Internet ; Korea ; Pesticides ; Poisons ; Toxicology* ; Workplace