1.Two Cases of Mycoplasma pneumoniae Pneumonia with A2063G Mutation in the 23S rRNA Gene in Siblings.
Joo Hee HONG ; Jin Kyong CHUN ; Young UH ; Ki Jin OH ; Juwon KIM ; Kap Jun YOON
Annals of Laboratory Medicine 2013;33(1):65-68
We describe 2 cases of pneumonia caused by the same macrolide-resistant Mycoplasma pneumoniae in siblings. M. pneumoniae was identified using real-time PCR. Direct sequence analysis of the 23S rRNA gene revealed a point mutation in V domain (A2063G) of the 23S rRNA gene.
Anti-Bacterial Agents/pharmacology
;
Child
;
Child, Preschool
;
Drug Resistance, Bacterial/drug effects
;
Humans
;
Macrolides/pharmacology
;
Male
;
Mutation
;
Mycoplasma pneumoniae/*genetics/isolation & purification
;
Pneumonia, Mycoplasma/*diagnosis/microbiology/radiography
;
RNA, Ribosomal, 23S/*analysis
;
Real-Time Polymerase Chain Reaction
;
Sequence Analysis, RNA
;
Siblings