No abstract available.
Malaria* ; Plasmodium vivax* ; Plasmodium*

No abstract available.
Blood Cell Count* ; Plasmodium vivax* ; Plasmodium*

There are two stages in the life circle of Plasmodium spp in humans: exoerythrocytic and erythrocytic stages. Hydroxychloroquine is the major chemotherapeutic agent against malarial parasites in their erythrocytic stage. The recurrence of Plasmodium vivax malaria, which is usually caused by an inadequate treatment or the presence of drug resistant parasites, has been reported frequently in the world, but rarely in Korea. We experienced two patients who recurred with P. vivax malaria after hydroxychloroquine therapy, and treating with insufficient doses of the drug was suspected as the cause of the recurrence.
Humans ; Hydroxychloroquine ; Korea ; Malaria, Vivax* ; Parasites ; Plasmodium ; Plasmodium vivax ; Recurrence

BACKGROUND: The cases of Plasmodium vivax malaria in Korea are mixed with long and short incubation periods. This study aims to define clinico-epidemiologic chracteristcs of Plasmodium vivax malaria in Korea. MATERIALS AND METHODS: We selected the civilian cases infected with P. vivax malaria in Korea from the epidemiological investigation data of 2001 to 2010, whose incubation periods could be estimated. The long and short incubation periods were defined by duration of infection and onset time, and the cases were compared by demographic factors and clinical symptom, infection and onset time. The correlation was analyzed between the proportion of cases in the infected region with the long incubation period and meteorological factors along with latitude. RESULTS: The length of the mean short and long incubation periods for the cases were 25.5 days and 329.4 days, respectively. The total number of the study subjects was 897, and the number cases of short and long incubation periods was 575 (64.1%) and 322 (35.9%), respectively. The aspect of incubation period showed a significant difference by region of infection; there was a higher proportion of long incubation period infection cases in Gangwon-do than in Gyeonggi-do and Incheon. The proportion of long incubation period cases showed significant correlation with latitude and temperature of August and September of the infected regions. CONCLUSIONS: Incubation period of P. vivax malaria in Korea showed significant difference by infected region, infection and onset time and the proportion of long incubation period cases showed significant correlation with latitude and meteorological factors of the infected regions.
Demography ; Korea ; Malaria ; Malaria, Vivax ; Meteorological Concepts ; Plasmodium ; Plasmodium vivax

Cerebral malaria is a severe neurological complication of Plasmodium falciparum infection. Cerebral malaria can lead to cerebral infarction by several mechanisms including systemic inflammatory response. The systemic inflammatory response is known to rarely occur in Plasmodium vivax infection. We report a patient who developed multiple cerebral infarctions following Plasmodium vivax infection.
Cerebral Infarction ; Humans ; Malaria, Cerebral ; Plasmodium ; Plasmodium falciparum ; Plasmodium vivax

Under the current epidemiological conditions as found in Korea, and considering the limited funds available for the malaria project, passive case detection proved to be the only practical mechanism to obtain reliable data required for the delimitation of malarious areas. The malaria map of the country was completed at the end of 1965. The high SPRs found among the blood smears reported by the PCD undts are due to the fact that the Korean farmer is able to recognize the clinical symptoms of the disease. The "fever case" reports are therefore actually "suspect malaria case" reports. The consistently high SPR has resulted in the detection of a large number of parasite carriers with the number of smears to be examined being reduced to a minimum. Although the medical group gave an important contribution to the success of the PCD service in Korea, the number of medical and public health facilities in the rural areas are still too small. This made it necessary to obtain the collaboration of laymen groups like school teachers, village chiefs etc., and their participation largely contributed to the success of the present programme. The degree of collaboration by the PCD units is higher in the more malarious areas. As no form of encouragement e.g., a reporting fee, has been given to these laymen during the past few years it becomes increasingly more difficult to maintain their active co-operation. It is felt that through passive case detection alone it will not be possible to collect adequate information to provide the proof for the complete interruption of transmission.
parasitology-protozoa ; Plasmodium vivax ; malaria ; diagnosis ; epidemiology

A 51-year-old man diagnosed with Plasmodium vivax malaria was transferred to our clinic with newly developed drowsy mentality and myoclonus after the initiation of hydroxychloroquine therapy. Following therapy to treat the vivax malaria and supportive care, the patient recovered completely with no sequelae. Cerebral complications caused by vivax malaria are very rare worldwide, and only two cases have been reported in Korea. Here, we report the third published case of P. vivax infection with cerebral complications in Korea.
Humans ; Hydroxychloroquine ; Korea ; Malaria, Cerebral ; Malaria, Vivax ; Middle Aged ; Myoclonus ; Plasmodium ; Plasmodium vivax

Malaria is the world's most important parasitic infec tion. Although it has been eradicated from temperate zones including Korea , increasing numbers of travellers visit tropical malarious countries and imported malaria becomes important medical problem in the developed countries. In Korea with increasing travellers to malaria endemic area, the incidence of imported malaria shows rising tendency same as the developed countries. It beco mes important to provide general personal protective me asures and chemoprophylaxis to trevellers, when employed in appropriate manner, that can be highly effective in preventing malaria . We recently experienced a case of imported Plasmodium vivax malaria with delayed mani festations due to inadequate chemoprophylaxis. A 53- year-old woman with history of trevel to East Africa 4 months ago and chief complaint of fever was diagnosed as tertian malaria. She had irregularly taken prophylatic antimalarial during travel and had not taken it after return but should have taken it at least 4 weeks after return.
Africa, Eastern ; Chemoprevention* ; Developed Countries ; Female ; Fever ; Humans ; Incidence ; Korea ; Malaria ; Malaria, Vivax* ; Plasmodium vivax* ; Plasmodium*

Resistance of falciparum malaria to antimalarial agents is prevalent in many areas, whereas chloroquine-resistant vivax malaria has been reported mainly around New Guinea since 1989. Concomitant with the spread of chloroquine-resistant P. vivax and increase in number of international travelers, imported cases of chloroquine-resistant vivax malaria in travelers returning from these areas has been reported. We experienced a case of chloroquine resistance P. vivax infection imported from Mangole Island, Indonesia. Its origin is confirmed not to be indigenous by the gene encoding analysis for the polymorphic region of apical membrane antigen-1 in P. vivax. Gene sequencing of the P. vivax mdr1 gene revealed only one substitution located at the codon 1076 (F1076L). The case was managed with oral quinidine with successful outcomes.
Antimalarials ; Chloroquine ; Codon ; Indonesia ; Malaria ; Malaria, Vivax ; Membranes ; New Guinea ; Plasmodium ; Plasmodium vivax ; Quinidine

Resistance of falciparum malaria to antimalarial agents is prevalent in many areas, whereas chloroquine-resistant vivax malaria has been reported mainly around New Guinea since 1989. Concomitant with the spread of chloroquine-resistant P. vivax and increase in number of international travelers, imported cases of chloroquine-resistant vivax malaria in travelers returning from these areas has been reported. We experienced a case of chloroquine resistance P. vivax infection imported from Mangole Island, Indonesia. Its origin is confirmed not to be indigenous by the gene encoding analysis for the polymorphic region of apical membrane antigen-1 in P. vivax. Gene sequencing of the P. vivax mdr1 gene revealed only one substitution located at the codon 1076 (F1076L). The case was managed with oral quinidine with successful outcomes.
Antimalarials ; Chloroquine ; Codon ; Indonesia ; Malaria ; Malaria, Vivax ; Membranes ; New Guinea ; Plasmodium ; Plasmodium vivax ; Quinidine