1.A History of Malaria in Modern Korea 1876-1945.
Korean Journal of Medical History 2011;20(1):53-82
Although it is not certain when malaria began to appear in Korea, malaria is believed to have been an endemic disease from ancient times. It was Dr. H. N. Allen (1858-1932) who made the first description and diagnosis of malaria in terms of Western medicine. In his first year report (1885) of Korean Government Hospital he mentioned malaria as the most prevalent disease. Very effective anti-malarial drug quinine was imported and it made great contribution in treating malaria. After Japan had annexed Korea in 1910, policies for public health system were fundamentally revised. Japan assumed control of Korean medical institutions and built high-quality Western hospitals for the health care of Japanese residents. The infectious diseases which were under special surveillance were cholera, typhoid fever, dysentery, typhus, scarlet fever, smallpox, and paratyphoid fever. Among chronic infectious diseases tuberculosis and leprosy were those under special control. Malaria, however, was not one of these specially controlled infectious diseases although it was widely spread throughout the peninsula. But serious studies on malaria were carried out by Japanese medical scientists. In particular, a Japanese parasitologist Kobayasi Harujiro(1884-1969) carried out extensive studies on human parasites, including malaria, in Korea. According to his study, most of the malaria in Korea turned out to be tertian fever. In spite of its high prevalence, malaria did not draw much attention from the colonial authorities and no serious measure was taken since tertian fever is a mild form of malaria caused by Plasmodium vivax and is not so much fatal as tropical malaria caused by P. falciparum. And tertian malaria was easily controlled by taking quinine. Although the majority of malaria in Korea was tertian fever, other types were not absent. Quartan fever was not rarely reported in 1930s. The attitude of colonial authorities toward malaria in Korea was contrasted with that in Taiwan. After Japan had set out to colonize Taiwan as a result of Sino-Japanese war, malaria in Taiwan was a big obstacle to the colonization process. Therefore, a lot of medical scientists were asked to engage the malaria research in order to handle health problems in colonized countries caused by malaria. Unlike the situation in Taiwan, malaria in Korea did not cause a serious health problem as in Taiwan. However, its risk was not negligible. In 1933 there were almost 130,000 malaria patients in Korea and 1,800 patients among them died of malaria. The Japanese Government General took measures to control malaria especially during the 1930s and the number of patients decreased. However, as Japan engaged in the World War II, the general hygienic state of the society worsened and the number of malarial patients increased. The worsened situation remains the same after Liberation (1945) and during the Korean war (1950-53).
Colonialism/history
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History, 19th Century
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History, 20th Century
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Humans
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Korea
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Malaria/diagnosis/drug therapy/*history
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Malaria, Vivax/diagnosis/drug therapy/history
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Microscopy, Polarization
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Plasmodium malariae/isolation & purification
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Plasmodium ovale/isolation & purification
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Plasmodium vivax/isolation & purification
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Quinine/history/therapeutic use
2.Prevalence of malaria infection in Sarbaz, Sistan and Bluchistan province.
Youssefi Mohammad REZA ; Rahimi Mohammad TAGHI
Asian Pacific Journal of Tropical Biomedicine 2011;1(6):491-492
OBJECTIVETo survey malaria prevalence in Sarbaz from April 2009 to October 2010.
METHODSEpidemiological data of 1 464 confirmed malarial patients were analyzed according to demographic status, sex, age, nationality, isolated species and residence place.
RESULTSThe majority of patients were male 950 (64.8%) but 514 (35.2%) were female. 82.5% of patients were Iranian, 14% Pakistani immigrants, and 3.5% Afghan immigrants. Data collected showed that 90% of isolated species were Plasmodium vivax, 7.8% Plasmodium falciparum, and 2.2% Plasmodium malariae and mixed species.
CONCLUSIONSTherefore, it is crystal clear that refugees should be prohibited by government and controlled by experts in health centers in order to campaign effectively with this life threating disease.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Demography ; Ethnic Groups ; Female ; Humans ; Infant ; Infant, Newborn ; Iran ; epidemiology ; Malaria ; epidemiology ; parasitology ; Male ; Middle Aged ; Plasmodium falciparum ; isolation & purification ; Plasmodium malariae ; isolation & purification ; Plasmodium vivax ; isolation & purification ; Prevalence ; Young Adult
3.A Case of Imported Plasmodium malariae Malaria.
Yun Ji HONG ; Sun Young YANG ; Kyunghoon LEE ; Taek Soo KIM ; Hong Bin KIM ; Kyoung Un PARK ; Junghan SONG ; Eui Chong KIM
Annals of Laboratory Medicine 2012;32(3):229-233
Malaria, the most common vector-borne parasite infection worldwide, results from infection by Plasmodium species. Approximately 80% of malaria cases are caused by P. vivax, which is broadly distributed from tropical to temperate regions; P. falciparum is the second most common infectious species. P. malariae and P. ovale are responsible for a relatively small proportion of malaria cases. Here, we report the case of a 23-yr-old Korean woman who acquired a P. malariae infection while visiting the Republic of Ghana in West Africa for business. She was diagnosed with P. malariae malaria on the basis of peripheral blood smear (PBS) and species-specific conventional and real-time PCR assays for 18S rRNA. She was treated with hydroxychloroquine, and the resulting PBS examination on day 2 suggested that negative conversion occurred. At her 1-month follow-up, however, both the PBS examination and molecular test for malaria demonstrated recurrent parasitemia. We started rescue therapy with mefloquine, and the patient recovered successfully. This is an important finding suggesting possible late recrudescence of a chloroquine-resistant P. malariae strain identified not only by its morphological features, but also by molecular tests.
Antimalarials/therapeutic use
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Drug Resistance
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Female
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Humans
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Hydroxychloroquine/therapeutic use
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Malaria/*diagnosis/drug therapy/parasitology
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Mefloquine/therapeutic use
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Plasmodium malariae/genetics/*isolation & purification
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RNA, Ribosomal, 18S/genetics
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Real-Time Polymerase Chain Reaction
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Recurrence
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Young Adult