No abstract available.
Animals ; Mice* ; Plaque, Atherosclerotic*

Cytophagocytosis ; Humans ; Plaque, Atherosclerotic ; physiopathology

Humans ; PPAR gamma ; Plaque, Atherosclerotic

Diagnostic Imaging ; trends ; Humans ; Plaque, Atherosclerotic ; diagnosis

Endothelium ; Epithelial-Mesenchymal Transition ; Humans ; Plaque, Atherosclerotic

To solve the problem of stent malapposition of intravascular stents, explore the design method of intravascular body-fitted stent structure and to establish an objective apposition evaluation method, the support and apposition performance of body-fitted stent in the stenotic vessels with different degrees of calcified plaque were simulated and analyzed. The traditional tube-mesh-like stent model was constructed by using computational aided design tool SolidWorks, and based on this model, the body-fitted stent model was designed by means of projection algorithm. Abaqus was used to simulate the crimping-expansion-recoil process of the two stents in the stenotic vessel with incompletely calcified plaque and completely calcified plaque respectively. A comprehensive method for apposition evaluation was proposed considering three aspects such as separation distance, fraction of non-contact area and residual volume. Compared with the traditional stent, the separation distances of the body-fitted stent in the incompletely calcified plaque model and the completely calcified plaque model were decreased by 21.5% and 22.0% respectively, the fractions of non-contact areas were decreased by 11.3% and 11.1% respectively, and the residual volumes were decreased by 93.1% and 92.5% respectively. The body-fitted stent improved the apposition performance and was effective in both incompletely and completely calcified plaque models. The established apposition performance evaluation method of stent considered more geometric factors, and the results were more comprehensive and objective.
Constriction, Pathologic/surgery* ; Humans ; Plaque, Atherosclerotic ; Stents

The use of IVUS provides information about the lumen and arterial wall, the location and extent of atherosclerotic plaque and the state of the arterial wall after PCI. The use of IVUS after insertion of an intracoronary stent has currently increased, while conflicting evidence exists concerning the long-term benefits of IVUS. We report here on a case of surgical removal of an entrapped and fractured IVUS catheter during insertion of intracoronary stents, and we include a review of the relevant literature.
Cardiac Catheterization ; Catheters ; Foreign Bodies ; Plaque, Atherosclerotic ; Stents

Humans ; Microvessels ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Plaque, Atherosclerotic ; pathology

OBJECTIVEThis coronary artery spasm review aimed to explore the most possible pathogenic trigger mechanism of vulnerable plaque rupture.

DATA SOURCESData used in this coronary artery spasm review were mainly from Medline and Pubmed in English.

STUDY SELECTIONThese reports from major review on coronary artery spasm. and these research included coronary artery conception, pathogenesis of spasm, mechanisms of plaque rupture, epidemiological evidence, clinical manifestation and the relationship between coronary artery spasm and vulnerable plaque rupture.

RESULTSCoronary artery spasm is somehow related to the presence of atherosclerotic intima disease in the coronary artery. However, chronic low-grade inflammation causes coronary vessel smooth muscle cell hypersensitivity, which can directely cause coronary artery spasm. Myocardial infarction and sudden cardiac death may be initiated by a sudden intense localized contraction of coronary artery smooth muscle.

CONCLUSIONCoronary artery spasm may be one trigger that can initiate and exacerbate vulnerable plaque rupture.

Animals ; Atherosclerosis ; diet therapy ; physiopathology ; Humans ; Plaque, Atherosclerotic ; drug therapy