1.Lobelia chinensis: chemical constituents and anticancer activity perspective.
Mei-Wan CHEN ; Wen-Rong CHEN ; Jin-Ming ZHANG ; Xiao-Ying LONG ; Yi-Tao WANG
Chinese Journal of Natural Medicines (English Ed.) 2014;12(2):103-107
Research has demonstrated that many chemical constituents dominated by piperidine alkaloids and flavonoids, such as lobelanidine, lobeline, and lobelanine, have been obtained from Lobelia chinensis Lour. Experimental studies and clinical applications have also indicated that L. chinensis possesses a number of pharmacological activities (e.g., diuretic, choleretic, breathing excitement, anti-venom, anti-bacterial, and anticancer). This paper focuses on the properties, chemical constituents, and anticancer activity of L. chinensis to clarify the connection among them, and identify the active anticancer compounds. This work serves as the foundation for further research and development of L. chinensis.
Alkaloids
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pharmacology
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therapeutic use
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Animals
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Antineoplastic Agents, Phytogenic
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pharmacology
;
therapeutic use
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Flavonoids
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pharmacology
;
therapeutic use
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Humans
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Lobelia
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chemistry
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Neoplasms
;
drug therapy
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Phytotherapy
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Plant Extracts
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pharmacology
;
therapeutic use
2.Phytochemistry, pharmacology and medicinal properties of Carthamus tinctorius L.
Jinous ASGARPANAH ; Nastaran KAZEMIVASH
Chinese journal of integrative medicine 2013;19(2):153-159
Carthamus tinctorius L. is commonly known as Safflower. C. tinctorius extracts and oil are important in drug development with numerous pharmacological activities in the world. This plant is cultivated mainly for its seed, which is used as edible oil. For a long time C. tinctorius has been used in traditional medicines as a purgative, analgesic, antipyretic and an antidote to poisoning. It is a useful plant in painful menstrual problems, post-partum hemorrhage and osteoporosis. C. tinctorius has recently been shown to have antioxidant, analgesic, anti-inflammatory and antidiabetic activities. Carthamin, safflower yellow are the main constituents in the flower of C. tinctorius. Carthamidin, isocarthamidin, hydroxysafflor yellow A, safflor yellow A, safflamin C and luteolin are the main constituents which are reported from this plant. Caryophyllene, p-allyltoluene, 1-acetoxytetralin and heneicosane were identified as the major components for C. tinctorius flowers essential oil. Due to the easy collection of the plant and being widespread and also remarkable biological activities, this plant has become both food and medicine in many parts of the world. This review presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of C. tinctorius.
Animals
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Carthamus tinctorius
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chemistry
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Drugs, Chinese Herbal
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pharmacology
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therapeutic use
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Humans
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Phytotherapy
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Plant Extracts
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chemistry
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pharmacology
;
therapeutic use
3.Natural alkaloids: basic aspects, biological roles, and future perspectives.
Shi QIU ; Hui SUN ; Ai-Hua ZHANG ; Hong-Ying XU ; Guang-Li YAN ; Ying HAN ; Xi-Jun WANG
Chinese Journal of Natural Medicines (English Ed.) 2014;12(6):401-406
Natural products have gained popularity worldwide for promoting healthcare, as well as disease prevention. Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation, antibacterial, antiviral, insecticidal, and antimetastatic effects on various types of cancers both in vitro and in vivo. This paper focuses on the naturally-derived alkaloids such as berberine, matrine, piperine, fritillarine, and rhynchophylline, etc., and summarizes the action mechanisms of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as drugs is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made. Following this, it is hoped that as a result of this review, there will be a greater awareness of the excellent promise that natural alkaloids show for use in the therapy of diseases.
Alkaloids
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pharmacology
;
therapeutic use
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Animals
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Anti-Inflammatory Agents
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pharmacology
;
therapeutic use
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Antineoplastic Agents
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pharmacology
;
therapeutic use
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Biological Products
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pharmacology
;
therapeutic use
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Humans
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Hypoglycemic Agents
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pharmacology
;
therapeutic use
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Phytotherapy
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Plant Extracts
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pharmacology
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therapeutic use
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Plants
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chemistry
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Porifera
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chemistry
4.Ethnobotany and phytopharmacology of Pinus roxburghii Sargent: a plant review.
Pawan KAUSHIK ; E-mail: PWN.KAUSHIK1@GMAIL.COM. ; Dhirender KAUSHIK ; Sukhbir Lal KHOKRA
Journal of Integrative Medicine 2013;11(6):371-376
Traditional medicine is a blend of information gathered over generations from various communities and cultures. Pinus roxburghii Sargent (Pinaceae) commonly known as "chir pine" is widely used in traditional and folkloric systems of medicine. The all parts of the plant are believed to possess medicinal qualities in Ayurvedic and Unani systems of medicine. In these traditional systems of medicine, the plant is used to heal many diseases, including afflictions of the eyes, ears, throat, blood, and skin. The plant parts are rich in various bioactive compounds such as α-pinene, abietic acid, quercetin and xanthone. Resin acids and flavanoid form a major portion of these bioactive compounds. This review presents examples of traditional medicinal uses for P. roxburghii, and subsequently explores the current understanding of the chemical, pharmacological, and biochemical properties of the extracts and the main active constituents found in each tissue of the plant. Clinical trial information is also included where available. Careful evaluation of these data may be helpful for scientists and researchers to discover and evaluate the specific chemical entities responsible for the traditional medicinal uses of P. roxburghii.
Animals
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Ethnobotany
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Humans
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Phytotherapy
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Pinus
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chemistry
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Plant Extracts
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pharmacology
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therapeutic use
5.Momordica charantia fruit extract with antioxidant capacity improves the expression of tyrosine-phosphorylated proteins in epididymal fluid of chronic stress rats.
Supatcharee ARUN ; Therachon KAMOLLERD ; Nareelak TANGSRISAKDA ; Sudtida BUNSUEB ; Arada CHAIYAMOON ; Alexander Tsang-Hsien WU ; Sitthichai IAMSAARD
Journal of Integrative Medicine 2022;20(6):534-542
OBJECTIVE:
Although the protective effects of Momordica charantia L. (MC) extract on chemical-induced testicular damage have been studied, the preventive effects of MC extract on functional proteins in the epididymis under chronic stress have never been reported. This study investigated the protective effects of MC fruit extract on protein secretion, especially tyrosine-phosphorylated proteins, in the epididymis of rats exposed to chronic unpredictable stress (CUS).
METHODS:
Total phenolic compounds (TPC), total flavonoid compounds (TFC) and antioxidant capacities of MC extract were measured. Adult male rats were divided into 4 groups: control group, CUS group, and 2 groups of CUS that received different doses of MC extract (40 or 80 mg/kg). In treated groups, rats were given MC daily, followed by induction of CUS (1 stressor was randomly applied from a battery of 9 potential stressors) for 60 consecutive days. Plasma corticosterone and testosterone levels were analyzed after the end of experiment. Expressions of heat-shock protein 70 (HSP-70) and tyrosine-phosphorylated proteins present in the fluid of the head and tail of the epididymis were quantified using Western blot.
RESULTS:
MC extract contained TPC of (19.005 ± 0.270) mg gallic acid equivalents and TFC of (0.306 ± 0.012) mg catechin equivalents per gram, and had 2,2-diphenyl-1-picrylhydrazyl antioxidant capacity of (4.985 ± 0.086) mg trolox equivalents per gram, radical 50% inhibitory concentration of (2.011 ± 0.008) mg/mL and ferric reducing antioxidant power of (23.697 ± 0.819) µmol Fe(II) per gram. Testosterone level in the epididymis was significantly increased, while the corticosterone level was significantly improved in groups treated with MC extract, compared to the CUS animals. Particularly, an 80 mg/kg dose of MC extract prevented the impairments of HSP-70 and tyrosine-phosphorylated protein expressions in the luminal fluid of the epididymis of CUS rats.
CONCLUSION
MC fruit extract had antioxidant activities and improved the functional proteins secreted from the head and tail of the epididymis. It is possible to develop the MC fruit extract as a male fertility supplement for enhancing functional sperm maturation in stressed men.
Male
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Rats
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Animals
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Antioxidants/pharmacology*
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Tyrosine/metabolism*
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Plant Extracts/therapeutic use*
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Corticosterone
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Seeds
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Testosterone
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Fruit/metabolism*
6.Modulation of signal transduction pathways by natural compounds in cancer.
Alok RANJAN ; Neel M FOFARIA ; Sung-Hoon KIM ; Sanjay K SRIVASTAVA
Chinese Journal of Natural Medicines (English Ed.) 2015;13(10):730-742
Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive compounds with excellent therapeutic efficacy. Numerous phytochemicals from nature have been investigated for anticancer properties. In this review article, we discuss several natural compounds, which have shown anti-cancer activity. Natural compounds induce cell cycle arrest, activate intrinsic and extrinsic apoptosis pathways, generate Reactive Oxygen Species (ROS), and down-regulate activated signaling pathways, resulting in inhibition of cell proliferation, progression and metastasis of cancer. Several preclinical studies have suggested that natural compounds can also increase the sensitivity of resistant cancers to available chemotherapy agents. Furthermore, combining FDA approved anti-cancer drugs with natural compounds results in improved efficacy. On the basis of these exciting outcomes of natural compounds against several cancer types, several agents have already advanced to clinical trials. In conclusion, preclinical results and clinical outcomes against cancer suggest promising anticancer efficacy of agents from natural sources.
Animals
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Antineoplastic Agents, Phytogenic
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pharmacology
;
therapeutic use
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Humans
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Magnoliopsida
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chemistry
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Neoplasms
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drug therapy
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Phytochemicals
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pharmacology
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therapeutic use
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Phytotherapy
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Plant Extracts
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pharmacology
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therapeutic use
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Signal Transduction
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drug effects
7.Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Rhizoma phragmitis: A Narrative Review.
Yuan REN ; Ge-Dan CUI ; Li-Sha HE ; Huan YAO ; Chang-Yan ZI ; Yong-Xiang GAO
Chinese journal of integrative medicine 2022;28(12):1127-1136
Rhizoma phragmitis is a common Chinese herbal medicine whose effects are defined as 'clearing heat and fire, promoting fluid production to quench thirst, eliminating irritability, stopping vomiting, and disinhibiting urine'. During the Novel Coronavirus epidemic in 2020, the Weijing Decoction and Wuye Lugen Decoction, with Rhizoma phragmitis as the main herbal component, were included in The Pneumonia Treatment Protocol for Novel Coronavirus Infection (Trial Version 5) due to remarkable antiviral effects. Modern pharmacological studies have shown that Rhizoma phragmitis has antiviral, antioxidative, anti-inflammatory, analgesic, and hypoglycemic functions, lowers blood lipids and protects the liver and kidney. This review aims to provide a systematic summary of the botany, traditional applications, phytochemistry, pharmacology and toxicology of Rhizoma phragmitis.
Humans
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Plant Extracts/pharmacology*
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Rhizome
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Drugs, Chinese Herbal/therapeutic use*
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Antioxidants/therapeutic use*
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Antiviral Agents/therapeutic use*
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Medicine, Chinese Traditional
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Phytochemicals/therapeutic use*
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Ethnopharmacology
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COVID-19 Drug Treatment
8.Cancer therapy using natural ligands that target estrogen receptor beta.
Gangadhara R SAREDDY ; Ratna K VADLAMUDI
Chinese Journal of Natural Medicines (English Ed.) 2015;13(11):801-807
Estrogen receptor beta (ERβ) is one of the two key receptors (ERα, ERβ) that facilitate biological actions of 17β-estradiol (E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during progression of many tumors. ERβ facilitates estrogen signaling by both genomic (classical and non-classical) and extra-nuclear signaling. Emerging evidence suggests that ERβ functions as a tissue-specific tumor suppressor with anti-proliferative actions. Recent studies have identified a number of naturally available selective ERβ agonists. Targeting ERβ using its naturally available ligands is an attractive approach for treating and preventing cancers. This review presents the beneficial actions of ERβ signaling and clinical utility of several natural ERβ ligands as potential cancer therapy.
Antineoplastic Agents, Phytogenic
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pharmacology
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therapeutic use
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Equol
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pharmacology
;
therapeutic use
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Estrogen Receptor beta
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antagonists & inhibitors
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metabolism
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Flavanones
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pharmacology
;
therapeutic use
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Genistein
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pharmacology
;
therapeutic use
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Glycyrrhiza
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chemistry
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Humans
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Ligands
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Neoplasms
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drug therapy
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metabolism
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Phytotherapy
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Plant Extracts
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pharmacology
;
therapeutic use
;
Soybeans
;
chemistry
9.Current natural products with antihypertensive activity.
Ren-Ren BAI ; Xiao-Ming WU ; Jin-Yi XU
Chinese Journal of Natural Medicines (English Ed.) 2015;13(10):721-729
Natural products have been an important source of new drugs, which also played a dominant role in the discovery and research of new drugs for the treatment of hypertension. This review article reviews the recent progress in the research and development of natural lead compounds with antihypertensive activity, including alkaloids, diterpenes, coumarins, flavonoids, and peptides. We summarized their structures, sources, as well as the antihypertensive mechanisms. These information provides instructive reference for the following structural modifications and optimization.
Antihypertensive Agents
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pharmacology
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therapeutic use
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Biological Products
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pharmacology
;
therapeutic use
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Humans
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Hypertension
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drug therapy
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Magnoliopsida
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chemistry
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Peptides
;
pharmacology
;
therapeutic use
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Phytochemicals
;
pharmacology
;
therapeutic use
;
Phytotherapy
;
Plant Extracts
;
pharmacology
;
therapeutic use
10.Hypolipidemic activity of a hydroalcoholic extract of Cyperus scariosus Linn. root in guinea pigs fed with a high cholesterol diet.
Hiren M CHAWDA ; Divyesh R MANDAVIA ; Pravin H PARMAR ; Seema N BAXI ; Chandrabhanu R TRIPATHI
Chinese Journal of Natural Medicines (English Ed.) 2014;12(11):819-826
Lipid-lowering and antioxidant activities of a hydroalcoholic extract of Cyperus scariosus Linn. root (HCS) were evaluated in guinea pigs fed with a high cholesterol diet. Serum lipid profile (total cholesterol, triglycerides, LDL-C, VLDL-C, and HDL-C), atherogenic indices and serum enzymes (ALT, AST, ALP, LDH, and CK-MB) were performed in each group at 0 days and at the end of 60 days. Histological study of liver and kidney was done in groups 1, 2, 5, 6 and 7. The total phenolic and flavonoid content in HCS and its antioxidant activity were evaluated by the DPPH assay. Both doses of HCS decreased serum lipid profile and atherogenic indices (P < 0.05). HCS has lipid lowering, immunosuppressive and antioxidant properties, and mays have value in atherosclerosis prevention. The higher dose of HCS also reduced serum AST, ALP, and LDH levels and rosuvastatin increased AST and ALP levels (P < 0.05). Histology of the liver showed decreased lipid accumulation and improvement in hepatocytes in HCS-treated animals. The antioxidant activity of HCS may be responsible for its lipid lowering and cytoprotective action. HCS had significant lipid lowering and antioxidant activity, which; may be due to the phenolic compounds. HCS may be a safe and cost effective alternative to current statin therapy for patients with dyslipidaemia.
Animals
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Cyperus
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Female
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Guinea Pigs
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Hypercholesterolemia
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drug therapy
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Hypolipidemic Agents
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pharmacology
;
therapeutic use
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Kidney
;
pathology
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Liver
;
pathology
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Male
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Mice
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Plant Extracts
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pharmacology
;
therapeutic use
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Plant Roots
;
chemistry