No abstract available.
Pituitary Neoplasms*

No abstract available.
Pituitary Neoplasms*

No abstract available.
Pituitary Neoplasms*

Computation of three dimensional dose distribution using CT image and RT plan was applied to a case of pituitary adenoma. Algorithm was based on two dimensional Tissue Maximum Ratio model extended to the third dimension. The resulting isodose curve of transeverse, coronal and sagittal section was demonstrated. This RT plan allows computation of dose distribution in any arbitarily defined plane in addition to conventional cross sectional view.
Pituitary Neoplasms*

A collision tumor involving metastasis to a pituitary adenoma is rare. We describe a case of a 68-year-old Bidayuh woman with underlying treatment-responsive lung adenocarcinoma, who presented with mass effect, panhypopituitarism and polyuria. Her initial imaging study reported pituitary macroadenoma, and she was treated with hormone replacement therapy. She then underwent transsphenoidal tumor debulking surgery with subsequent histopathological findings of a collision tumor of an adenocarcinoma with metastasis to a non-functioning pituitary adenoma.
Pituitary Neoplasms

Intracranial lipomas are benign tumors that may occasionally be found in the suprasellar cistern while pituitary adenomas are far more common brain tumors. Pituitary adenomas may rarely coexist with other intracranial tumors in the sellar-suprasellar region. We share a unique case of a patient with coexisting non-functioning pituitary adenoma and sellar-suprasellar lipoma presenting with blurring of vision. We report a 55-year-old male presenting with a two-year history of blurring of vision with findings of a 2.7 x 3.0 x 3.2 cm homogeneously enhancing lobulated isointense mass on the sellar-suprasellar region. Hormonal workups revealed low cortisol and mildly elevated prolactin. He initially underwent endonasal transsphenoidal excision of the tumor which revealed to be a lipoma on histopathology. Due to minimal improvement of vision from the subtotal excision, he underwent repeat surgery through the transcranial approach which in turn showed a pituitary adenoma. The co-occurrence of two sellar-suprasellar tumors with different histology is rare, as most of the evidence is based on only a handful of case series. Intracranial lipomas result from persistence and abnormal differentiation of the meninx primitiva during the development of the subarachnoid cisterns. On the other hand, pituitary tumorigenesis is still largely unclear but appears to involve multiple tumor suppressor genes, oncogenes, cell cycle deregulation factors, and miRNAs. Given the differing pathogenesis of each tumor type, the coexistence may only be coincidental. The best surgical approach in this situation is unknown but the focus is on complete excision of the adenoma.
Pituitary Neoplasms

To report the efficacy and safety of transsphenidal approach in a series of patients with pituitary adenoma, ninety-one consecutive patients undergoing transsphenoidal surgery of a pituitary adenoma at neurosurgical department, Cho Ray Hospital from January 2001 to June 2003 were included in this study. Postoperative results were analyzed. Total removal rate was 24.2% and partial removal rate was 7.7%. There were 4 patients had rhenorrhea and meningitis. Two patients died because of surgery. Normalization of visual defect was good. Transsphenoidal surgery is an effective and safe treatment for most patients with pituitary adenoma and could be considered the first choice therapy in most of the cases. Sublabial transseptal approach is suitable for our conditions.
Pituitary Neoplasms ; Surgery ; Therapeutics

The clinical manifestations, the endocrine examinations and imaging features (MRI) of 91 patients with pituitary adenomas who had undergone transsphenoidal microsurgery from 1/2001 to 6/2003 were analyzed. The patient population was 49.5% female and 50.5% male. Mean age was 40.4 years.71 patients (78%) experienced decreased visual acuity, 67 patients (73.6) experienced headache. The most frequent tumor type was clinically nonfunctioning adenoma (50%), followed by prolactin-secreting adenoma (34.1%), growth hormone-secreting adenoma (13.2%) and last adrenocorticotropin-secreting adenoma (7.7%). there were 86 macro adenomas (94.5%) and in 13 patients (14.3%) the tumor invaded cavernous sinus. mean height was 33.05 mm, length was 26.58mm and width was 29.71mm. Conclusions: Clinical manifestations of pituitary adenomas are the result of excess hormone secretion (acromegaly, hyperprolactinemia, hypercortisolism...) and to compression of the surrounding structures (headache, visual disturbance and ocular movement palsy). The endocrine examinations are very important for diagnosis and treatment. MRI is the first choice.
Pituitary Neoplasms ; Diagnosis

Recently, transsphenoidal approach is regarded as the principal method for the resection of pituitary tumor. The sublabial transseptal transsphenoidal hypophysectomy is a classical one, but it has certain limitations and postoperative problems. So various modifications of transsphenoidal hypophysectomy have been proposed. The columellar flap is one of such modified approaches.
Hypophysectomy ; Pituitary Neoplasms

Three cases of giant pituitray adenoma are reported. Two cases were operated by transsphenoidal approach and a case by transcranial approach. Transsphenoidal approach showed satisfactory results despite of marked suprasellar extension of tumors. We report rare giant pituitary adenomas with review of relevant literatures.
Adenoma ; Pituitary Neoplasms*