No abstract available.
Chlamydia trachomatis* ; Chlamydia* ; Doxycycline* ; Enoxacin* ; Erythromycin* ; Pipemidic Acid*

No abstract available.
Chlamydia trachomatis* ; Chlamydia* ; Doxycycline* ; Enoxacin* ; Erythromycin* ; Pipemidic Acid*

The use of lyophilised bone from calves as a heterograft was introduced by Maatz and Bauermeister in 1957 as an alternative to autografts and freeze-dried homografts which were then in general use. The Kiel bone was known to possess no antigenecity and serial radiographs revealed that it is incorporated into the recipient site by a process of creeping substitution from surrounding bone. In patients with benign bone tumors, the surgical dead space was filled with Kiel bone graft in the departments of orthopedic surgery, Pusan national university hospital. The results were followed up for more than 14 months, and were evaluated by the palin film findings. The results were as follows : l. Of the 22 cases, satisfactory result was obtained in 18 cases(81,8%). 2. The mean lesion size(diameter of lesion/diameter of bone)of success cases was 61.6%, and the mean lesion size of failed cases was 82.8%. 3. The duration from the Kiel bone graft to the evidence of new bone formation and remodelling was 10.5 months on an average with a range of 7months to 15months, and the duratin from the Kiel bone graft to the complete resorption of the Kiel bone was 45.7 months on an average with a range of 29 months to 66 months. 4. The causes of the failed cases were thought to be incomplete removal of the lesion, decreased vascularity due to repeated surgery, large size of the lesion, and the potentiality of tumor, 5. It was difficult to evaluate success rate according to underlying disease because the number of the cases was not large enough, but giant cell tumor showed high recurrence rate.
Allografts ; Autografts ; Busan ; Clinical Study ; Giant Cell Tumors ; Heterografts ; Humans ; Orthopedics ; Osteogenesis ; Pipemidic Acid ; Recurrence ; Transplants

Until recently, soliatry coin lesions of pulmonary disease hs been a conspicious problem in radiologic diagnosis, It is now well informed that CT has offered high resolution with its objective CT numbers to porvide additional information in terms of anatomic changes. Here by the aid of CT, the author gas reviewed retrospectively patients with various shape of round masses thus illustrating the advantage of it over conventional X-ray in diagnosis. 1. Total 53 patients, including 34 males and 19 females, aging between 19 to 76years old with nodule or mass of any size ranging 1 to 13cm in diameter were observed. 2. On palin chest X-raythey were indentified where 50 patients has single round nodule or mass, only one had two masses which were ecchinococcal cysts, and the rest two had invisible lesions only detected by CT. 3. With philips tomoscan 310, CTscan was taken with 12mm thick slice during quiet respiration. Using the ROI cursor the average CT number of thecentral area was calculated 1.0cm in side the outer border of the mass. 4. As a consequence of their pathologic features, they were itemized to 4 group as 36 solid, 9 cystic, 4 consolidative and 4 cavitary lesions. 5. Correctdiagnosis of 3 cystic lesions, 4 diffuse calcification, 1 A-V malformation were available by CT densitometry. 6.By the aid of better resolution and additional cross-sectional orientation of CT, 3 extrapulmonary lesions, 3segmental consolidations, 2 bronchocele, and 2 solitary metastasis, were helpful in diagnosis. 7. Also helpful indetermining the extent of intrathoracic extent of bronchogenic carcinoma for the same reason but given clues werenot more than the ordinary. 8. However, the limitation of the CT densitometry led to miss diagnosis of 3 examplesof cystic vs. solid lesions, and CT density of noncalcified granuloma together with bronchogenic carcinoma, didnot have a clear cut separation in between.
Aging ; Carcinoma, Bronchogenic ; Densitometry ; Diagnosis ; Female ; Granuloma ; Humans ; Lung Diseases ; Male ; Neoplasm Metastasis ; Numismatics ; Pipemidic Acid ; Radiography, Thoracic ; Respiration ; Retrospective Studies ; Thorax

OBJECTIVETo study the resistance and its mechanism of Shigellae spp. to quinolones.

METHODSSeventy-three clinical isolates were collected. Susceptibility tests of pipemidic adcid (PI), ofloxacin (OFL), norfloxacin (NOR), and ciprofloxacin (CIP) were performed in all clinical isolates and Shigella 51573. The N-terminal coding region of gyrA and parC were amplified by polymerase chain reaction (PCR) respectively. Restriction fragment length polymorphism (RFLP) was applied to all PCR procucts of gyrA and parC, and single strand conformational polymorphism analysis (SSCP) was also applied to PCR procucts of parC.

RESULTSThe resistance rates for all the Shigella spp. to PI, CIP, NOR and OFL were 79.5%, 60.3%, 41.1% and 36.9%. Sixty-seven strains (91.8%) were quinolone-reduced-sensitive isolates, in which 61 strains (91%) were found carrying mutations in gyrA with 5 strains (7.5%) found carrying mutations in parC. No mutation was found in 6 quinolone-sensitive isolates or Shigella 51573.

CONCLUSIONThe Shigella spp. had high resistance rates to quinolones. The target gene mutations which were mainly found in gyrA and secondarily in parC, played an important role in the quinolone-resistance in Shigella spp.

Anti-Infective Agents ; pharmacology ; Ciprofloxacin ; pharmacology ; DNA Gyrase ; genetics ; DNA Topoisomerase IV ; genetics ; Drug Resistance, Bacterial ; genetics ; Humans ; Microbial Sensitivity Tests ; Norfloxacin ; pharmacology ; Ofloxacin ; pharmacology ; Pipemidic Acid ; pharmacology ; Polymerase Chain Reaction ; Polymorphism, Single-Stranded Conformational ; Quinolones ; pharmacology ; Shigella ; drug effects ; genetics