Objective:To develop evidence-based postoperative nausea and vomiting (PONV) management program, so as to provide a reference for standardizing PONV management in Anesthesiology Department and reduce PONV incidence and severity of patients.Methods:From January to November 2021, based on the evidence clinical transformation model chart, the PONV management program in Anesthesiology Department was developed through evidence retrieval, quality evaluation, evidence summary, obstacle factor analysis and other methods, and 2 rounds of clinical practice reform were carried out. The implementation of quality review indicators of medical staff and the incidence of postoperative nausea, postoperative vomiting and PONV of patients and severity of postoperative nausea, postoperative vomiting were evaluated.Results:At baseline, after the first review and the second review, the implementation rate of quality review indicators of medical staff gradually increased, and the differences were statistically significant ( P<0.05) . After the second review, the incidence of postoperative nausea, postoperative vomiting and PONV and severity of postoperative nausea, postoperative vomiting decreased compared with the first review, and the differences were statistically significant ( P<0.05) . Conclusions:Evidence-based PONV management program can standardize the PONV management behavior of anesthesiology medical staff, reduce the incidence of postoperative nausea, postoperative vomiting and PONV and severity of postoperative nausea, postoperative vomiting, and improve the quality of PONV management.